Zobrazeno 1 - 10
of 3 634
pro vyhledávání: '"A. J. Johnston"'
Autor:
Craig Smail, Bing Ge, Marissa R. Keever-Keigher, Carl Schwendinger-Schreck, Warren A. Cheung, Jeffrey J. Johnston, Cassandra Barrett, Genomic Answers for Kids Consortium, Keith Feldman, Ana S. A. Cohen, Emily G. Farrow, Isabelle Thiffault, Elin Grundberg, Tomi Pastinen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract Emerging evidence implicates common genetic variation - aggregated into polygenic scores (PGS) - in the onset and phenotypic presentation of rare diseases. Here, we comprehensively map individual polygenic liability for 1102 open-source PGS
Externí odkaz:
https://doaj.org/article/ba3f8c0e8d37484786aec71e82e5e7fc
Autor:
Angela L. Hughson, Gary Hannon, Noah A. Salama, Tara G. Vrooman, Caroline A. Stockwell, Bradley N. Mills, Jesse Garrett-Larsen, Haoming Qiu, Roula Katerji, Lauren Benoodt, Carl J. Johnston, Joseph D. Murphy, Emma Kruger, Jian Ye, Nicholas W. Gavras, David C. Keeley, Shuyang S. Qin, Maggie L. Lesch, Jason B. Muhitch, Tanzy M.T. Love, Laura M. Calvi, Edith M. Lord, Nadia Luheshi, Jim Elyes, David C. Linehan, Scott A. Gerber
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 35, Iss 4, Pp 102350- (2024)
Pronounced T cell exhaustion characterizes immunosuppressive tumors, with the tumor microenvironment (TME) employing multiple mechanisms to elicit this suppression. Traditional immunotherapies, such as immune checkpoint blockade, often fail due to th
Externí odkaz:
https://doaj.org/article/f027f2b3c534440cbdc1ca41fe01b771
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract To understand how the human brain distinguishes itself from external stimulation, it was examined if motor predictions enable healthy adult volunteers to infer self-location and to distinguish their body from the environment (and other agent
Externí odkaz:
https://doaj.org/article/a4bf2c6aa3f848fda628f6c90824c5f5
Autor:
Kaitlyn M. St. Charles, Kimberly L. VanderWaal, Jon E. Anderson, Lee J. Johnston, Yuzhi Z. Li
Publikováno v:
Frontiers in Veterinary Science, Vol 11 (2024)
Tail biting is a multifactorial behavior that causes welfare and economic challenges in swine production. As of 2024, research exploring the influence of pig social structure on the development of tail biting is limited. The objective of this study w
Externí odkaz:
https://doaj.org/article/dc3f593c527e42059d61983b817e7436
Autor:
Zidong Zhang, Divya S. Subramaniam, Steven W. Howard, Kenton J. Johnston, William H. Frick, Kimberly Enard, Leslie Hinyard
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 17 (2024)
Background Despite the known benefits for individuals with heart failure (HF), incomplete data suggest a low use of palliative care (PC) for HF in the United States. We aimed to investigate the national PC use for adults with HF by determining when t
Externí odkaz:
https://doaj.org/article/93d6e88f0fdc4de297e811f2e0f375ac
Publikováno v:
Journal of CO2 Utilization, Vol 86, Iss , Pp 102911- (2024)
We investigate the potential to reduce costs and greenhouse gas emissions of the utilization of direct air capture of CO2 (DAC) for the production of algal biofuel. We examine four integrated designs for a DAC system comprised of solid amine monolith
Externí odkaz:
https://doaj.org/article/c4260387506143998c898d84fca04718
Autor:
Marissa R. Keever-Keigher, Lisa Harvey, Veronica Williams, Carrie A. Vyhlidal, Atif A. Ahmed, Jeffery J. Johnston, Daniel A. Louiselle, Elin Grundberg, Tomi Pastinen, Craig A. Friesen, Rachel Chevalier, Craig Smail, Valentina Shakhnovich
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionChronic inflammation of the gastrointestinal tissues underlies gastrointestinal inflammatory disorders, leading to tissue damage and a constellation of painful and debilitating symptoms. These disorders include inflammatory bowel diseases
Externí odkaz:
https://doaj.org/article/a2f85ac5e21041d7ad71c85d212e9cff
Autor:
Crystal Mackall, Holden T Maecker, Lekha Mikkilineni, Melody Smith, Saurabh Dahiya, Bita Sahaf, David Miklos, Sally Arai, Surbhi Sidana, Wen-Kai Weng, Dasom Lee, Anmol Goyal, Sushma Bharadwaj, Eric Lau, Mark P Hamilton, Hrishi Srinagesh, Alexandria Jensen, Jayasindhu Mallampet, Sarah Elkordy, Shriya Syal, Sunita Patil, Theresa Latchford, Laura J Johnston, Robert Lowsky, Robert Negrin, Andrew R Rezvani, Judith Shizuru, Everett H Meyer, Parveen Shiraz, Lori Muffly, Matthew J Frank
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 7 (2024)
Background Fludarabine in combination with cyclophosphamide (FC) is the standard lymphodepletion regimen for CAR T-cell therapy (CAR T). A national fludarabine shortage in 2022 necessitated the exploration of alternative regimens with many centers em
Externí odkaz:
https://doaj.org/article/4eeab2b9098d4e108c29937f804ef916
Autor:
Nazila Nazemof, Dalibor Breznan, Yasmine Dirieh, Erica Blais, Linda J. Johnston, Azam F. Tayabali, James Gomes, Premkumari Kumarathasan
Publikováno v:
Nanomaterials, Vol 14, Iss 19, p 1601 (2024)
Zinc oxide nanoparticles (NPs) are used in a wide range of consumer products and in biomedical applications, resulting in an increased production of these materials with potential for exposure, thus causing human health concerns. Although there are m
Externí odkaz:
https://doaj.org/article/84feaeb2902a402d96349df941744bb6
Autor:
Emily J. Johnston, Jess Tallis, Edward Cunningham-Oakes, Tessa Moses, Simon J. Moore, Sarah Hosking, Susan J. Rosser
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract Escin is a mixture of over 30 glycosylated triterpenoid (saponin) structures, extracted from the dried fruit of horse chestnuts. Escin is currently used as an anti-inflammatory, and has potential applications in the treatment of arthritis an
Externí odkaz:
https://doaj.org/article/45fe8550be604c0293f915b1a5d6929d