Zobrazeno 1 - 10
of 1 658
pro vyhledávání: '"A. J. Hilton"'
Autor:
Belamy B. Cheung, Ritu Mittra, Jayne Murray, Qian Wang, Janith A. Seneviratne, Mukesh Raipuria, Iris Poh Ling Wong, David Restuccia, Andrew Gifford, Alice Salib, Selina Sutton, Libby Huang, Parisa Vahidi Ferdowsi, Joanna Tsang, Eric Sekyere, Chelsea Mayoh, Lin Luo, Darren L. Brown, Jennifer L. Stow, Shizhen Zhu, Richard J. Young, Benjamin J. Solomon, Stephane Chappaz, Benjamin Kile, Andrew Kueh, Marco J. Herold, Douglas J. Hilton, Tao Liu, Murray D. Norris, Michelle Haber, Daniel R. Carter, Michael W. Parker, Glenn M. Marshall
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-13 (2024)
Abstract MYCN amplification predicts poor prognosis in childhood neuroblastoma. To identify MYCN oncogenic signal dependencies we performed N-ethyl-N-nitrosourea (ENU) mutagenesis on the germline of neuroblastoma-prone TH-MYCN transgenic mice to gene
Externí odkaz:
https://doaj.org/article/7aab45a11a28499aa2b12d59ee58078b
Autor:
Jayne E. Murray, Emanuele Valli, Giorgio Milazzo, Chelsea Mayoh, Andrew J. Gifford, Jamie I. Fletcher, Chengyuan Xue, Nisitha Jayatilleke, Firoozeh Salehzadeh, Laura D. Gamble, Jourdin R. C. Rouaen, Daniel R. Carter, Helen Forgham, Eric O. Sekyere, Joanna Keating, Georgina Eden, Sophie Allan, Stephanie Alfred, Frances K. Kusuma, Ashleigh Clark, Hannah Webber, Amanda J. Russell, Antoine de Weck, Benjamin T. Kile, Martina Santulli, Piergiuseppe De Rosa, Emmy D. G. Fleuren, Weiman Gao, Lorna Wilkinson-White, Jason K. K. Low, Joel P. Mackay, Glenn M. Marshall, Douglas J. Hilton, Federico M. Giorgi, Jan Koster, Giovanni Perini, Michelle Haber, Murray D. Norris
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract MYCN oncogene amplification is frequently observed in aggressive childhood neuroblastoma. Using an unbiased large-scale mutagenesis screen in neuroblastoma-prone transgenic mice, we identify a single germline point mutation in the transcript
Externí odkaz:
https://doaj.org/article/ee532e0c05a8415d9de099a04d9f475c
Autor:
Qike Wang, Genting Liu, Liping Yan, Wentian Xu, Douglas J. Hilton, Xianhui Liu, Wenya Pei, Xinyu Li, Jinbiao Wu, Haifeng Zhao, Dong Zhang, Mark A. Elgar
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-10 (2023)
Abstract The consequences of sub-lethal levels of ambient air pollution are underestimated for insects, for example, the accumulation of particulate matter on sensory receptors located on their antennae may have detrimental effects to their function.
Externí odkaz:
https://doaj.org/article/e16b4c44c55c45a3b6ac2be6a37a19ab
Autor:
J. Saiz-Lomas, M. Petri, I.Y. Lee, I. Syndikus, S. Heil, J.M. Allmond, L.P. Gaffney, J. Pakarinen, H. Badran, T. Calverley, D.M. Cox, U. Forsberg, T. Grahn, P. Greenlees, K. Hadyńska-Klȩk, J. Hilton, M. Jenkinson, R. Julin, J. Konki, A.O. Macchiavelli, M. Mathy, J. Ojala, P. Papadakis, J. Partanen, P. Rahkila, P. Ruotsalainen, M. Sandzelius, J. Sarén, S. Stolze, J. Uusitalo, R. Wadsworth
Publikováno v:
Physics Letters B, Vol 845, Iss , Pp 138114- (2023)
The spectroscopic quadrupole moment of the first 2+ state of 12C has been measured employing the Coulomb-excitation re-orientation technique. Our result of Qs(21+)=+9.3−3.8+3.5efm2 suggests a larger oblate deformation than previously reported. Comb
Externí odkaz:
https://doaj.org/article/8419ebe5635e47aab69975d5a0a4f643
Autor:
C. Biben, T. S. Weber, K. S. Potts, J. Choi, D. C. Miles, A. Carmagnac, T. Sargeant, C. A. de Graaf, K. A. Fennell, A. Farley, O. J. Stonehouse, M. A. Dawson, D. J. Hilton, S. H. Naik, S. Taoudi
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
The lineage relationship between blood and endothelial cells has been difficult to examine due to the multiphasic timing of hematopoiesis in the embryo. Here the authors use using in vivo barcoding technology to assess cell ancestry and show that blo
Externí odkaz:
https://doaj.org/article/6351cecfd0d64c5d8292c8dfe54dd2d9
Autor:
Peter J. Talling, Megan L. Baker, Ed L. Pope, Sean C. Ruffell, Ricardo Silva Jacinto, Maarten S. Heijnen, Sophie Hage, Stephen M. Simmons, Martin Hasenhündl, Catharina J. Heerema, Claire McGhee, Ronan Apprioual, Anthony Ferrant, Matthieu J. B. Cartigny, Daniel R. Parsons, Michael A. Clare, Raphael M. Tshimanga, Mark A. Trigg, Costa A. Cula, Rui Faria, Arnaud Gaillot, Gode Bola, Dec Wallance, Allan Griffiths, Robert Nunny, Morelia Urlaub, Christine Peirce, Richard Burnett, Jeffrey Neasham, Robert J. Hilton
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
This paper analyses the longest sediment flows measured in action on Earth. These seabed flows were caused by floods and spring tides, and flushed prodigious sediment and carbon volumes into the deep sea, as they accelerated for a thousand kilometres
Externí odkaz:
https://doaj.org/article/a2c09172229a4f8493f806598d4f127a
Autor:
A.-A. Beltran-Bless, G. Larocque, M. Brackstone, A. Arnaout, J.-M. Caudrelier, D. Boone, P. Fallah, T. Ng, P. Cross, N. Alqahtani, J. Hilton, L. Vandermeer, G. Pond, M. Clemons
Publikováno v:
Breast, Vol 68, Iss , Pp S127- (2023)
Externí odkaz:
https://doaj.org/article/6ad8a0d1c4a2422e97f575bfdf5e8459
BAF complex-mediated chromatin relaxation is required for establishment of X chromosome inactivation
Autor:
Andrew Keniry, Natasha Jansz, Linden J. Gearing, Iromi Wanigasuriya, Joseph Chen, Christian M. Nefzger, Peter F. Hickey, Quentin Gouil, Joy Liu, Kelsey A. Breslin, Megan Iminitoff, Tamara Beck, Andres Tapia del Fierro, Lachlan Whitehead, Andrew Jarratt, Sarah A. Kinkel, Phillippa C. Taberlay, Tracy Willson, Miha Pakusch, Matthew E. Ritchie, Douglas J. Hilton, Jose M. Polo, Marnie E. Blewitt
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Female embryonic stem cells (ESCs) are the ideal model to study X chromosome inactivation (XCI) establishment; however, these cells are challenging to keep in culture. Here the authors create fluorescent ‘Xmas’ reporter mice as a renewable source
Externí odkaz:
https://doaj.org/article/55d8f97f36464af78639b6d7c2a5c371
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-10 (2022)
Corso et al. employ a novel 25-year time series to show how variability in sea ice coverage and ocean temperatures impact larval abundance of an important forage fish, the Antarctic Silverfish. The authors provide insight into how current reductions
Externí odkaz:
https://doaj.org/article/7be1b3822d0946718bc9559d16264210
Autor:
Jaime M. Brozowski, Roman G. Timoshchenko, D. Stephen Serafin, Brittney Allyn, Jessica Koontz, Emily M. Rabjohns, Rishi R. Rampersad, Yinshi Ren, Amanda M. Eudy, Taylor F. Harris, David Abraham, Daniel Mattox, Clinton T. Rubin, Matthew J. Hilton, Janet Rubin, Nancy L. Allbritton, Matthew J. Billard, Teresa K. Tarrant
Publikováno v:
Stem Cell Research & Therapy, Vol 13, Iss 1, Pp 1-15 (2022)
Abstract Background The bone marrow niche supports hematopoietic cell development through intimate contact with multipotent stromal mesenchymal stem cells; however, the intracellular signaling, function, and regulation of such supportive niche cells
Externí odkaz:
https://doaj.org/article/124f702e78d146ed89416332f38c7248