Zobrazeno 1 - 10 of 80 pro vyhledávání: '"A. J. Hartshorn"'
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Fragment-based drug discovery using cryo-EM
Autor: Judith Reeks, Michael Saur, Harren Jhoti, Gabor Bunkoczi, Michael J. Hartshorn, Jing Dong, Pamela A. Williams
Publikováno v: Drug Discovery Today. 25:485-490
Recent advances in electron cryo-microscopy (cryo-EM) structure determination have pushed the resolutions obtainable by the method into the range widely considered to be of utility for drug discovery. Here, we review the use of cryo-EM in fragment-ba
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9b2b90732ae4afc7a9a3b0bdc137819
https://doi.org/10.1016/j.drudis.2019.12.006
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5
Assessing filter robustness at drinking water treatment plants
Autor: Peter Jarvis, Andrew J. Hartshorn, Bruce Jefferson, A. Upton, George Prpich, Jitka MacAdam
Publikováno v: Water and Environment Journal. 29:16-26
This investigation explores the use of five-parameter logistic curve fitting in quantifying turbidity robustness and risk scoring in clarification and filtrations stages of several surface water treatment works in the Anglian Water region of the Unit
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6c7bf8dd288fa86c59de37ca0a734b09
https://doi.org/10.1111/wej.12094
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7
Generic dealkylation: a tool for increasing the hit-rate of metabolite rationalization, and automatic customization of mass defect filters
Autor: Russell J. Mortishire-Smith, Mike J. Hartshorn, Jeff Goshawk, Jose Castro-Perez, Kate Yu, Alastair Hill, John P. Shockcor
Publikováno v: Rapid Communications in Mass Spectrometry. 23:939-948
The use of exact mass liquid chromatography/mass spectrometry (LC/MS) for drug metabolism studies has increased significantly in recent years. Firstly, exact mass measurements facilitate identification of standard biotransformations through the use o
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f232fbb262b648d516cb1a09b54fae9
https://doi.org/10.1002/rcm.3951
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8
Optimizing the Management of Moore Type I Postero-Medial Split Fracture Dislocations of the Tibial Head: Description of the Lobenhoffer Approach
Autor: Philip F. Stahel, Johannes K. M. Fakler, Wade R. Smith, Cody J. Hartshorn, Steven J. Morgan, Mark Ryzewicz
Publikováno v: Journal of Orthopaedic Trauma. 21:330-336
Summary: Moore type I tibial plateau fracture-dislocations pose a significant challenge to the treating surgeon. The displaced posteromedial fragment is difficult to reduce and adequately stabilize through traditional approaches. The Lobenhoffer appr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec95940ba0249e2976f45e13d4bc5a1f
https://doi.org/10.1097/bot.0b013e318055603c
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9
Application of Fragment Screening by X-ray Crystallography to β-Secretase
Autor: Nicola G. Wallis, Christopher William Murray, Miles Congreve, Rachel McMenamin, Michael J. Hartshorn, Owen Callaghan, Martyn Frederickson, Sahil Patel, Anne Cleasby, Gianni Chessari
Publikováno v: Journal of Medicinal Chemistry. 50:1116-1123
This paper describes an application of fragment screening to the aspartyl protease enzyme, beta-secretase (BACE-1), using high throughput X-ray crystallography. Three distinct chemotypes were identified by X-ray crystallography as binding to the cata
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80e5c1db6e64af52e9fa3f704dce53d2
https://doi.org/10.1021/jm0611962
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10
Automated Protein–Ligand Crystallography for Structure-Based Drug Design
Autor: Marcel L. Verdonk, Andrew Sharff, Michael J. Hartshorn, Wijnand T. M. Mooij, Harren Jhoti, Ian J. Tickle
Publikováno v: ChemMedChem. 1:827-838
An approach to automate protein -liqand crystallography is pre sented, with the aim of increasing the number of structures available to structure-based drug design. The methods we propose deal with the automatic interpretation of diffraction data for
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbed3f1880ac7fcca2bca608f63db5ee
https://doi.org/10.1002/cmdc.200600074
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