Zobrazeno 1 - 10
of 2 537
pro vyhledávání: '"A. J. Harrington"'
Autor:
George Gabriel Bitar, Melissa Persad, Alina Dragan, Adebayo Alade, Pablo Jiménez-Labaig, Edward Johnston, Samuel J Withey, Nicos Fotiadis, Kevin J. Harrington, Derfel ap Dafydd
Publikováno v:
Cancer Imaging, Vol 24, Iss 1, Pp 1-9 (2024)
Abstract Background Directly-injected therapies (DIT) include a broad range of agents within a developing research field in cancer immunotherapy, with encouraging clinical trial results in various tumour subtypes. Currently, the majority of such ther
Externí odkaz:
https://doaj.org/article/eef5eaa576644c3b9cd88fed32637749
Autor:
Emmanuel C. Patin, Pablo Nenclares, Charleen Chan Wah Hak, Magnus T. Dillon, Anton Patrikeev, Martin McLaughlin, Lorna Grove, Shane Foo, Heba Soliman, Joao P. Barata, Joanna Marsden, Holly Baldock, Jim Gkantalis, Victoria Roulstone, Joan Kyula, Amy Burley, Lisa Hubbard, Malin Pedersen, Simon A. Smith, Eleanor Clancy-Thompson, Alan A. Melcher, Masahiro Ono, Antonio Rullan, Kevin J. Harrington
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract The combination of radiotherapy/chemoradiotherapy and immune checkpoint blockade can result in poor outcomes in patients with locally advanced head and neck squamous cell carcinoma (HNSCC). Here, we show that combining ATR inhibition (ATRi)
Externí odkaz:
https://doaj.org/article/e03ce8982c174566b0e3ce1d9a1fbd10
Autor:
Emilie Duthoo, Jérôme Delroisse, Barbara Maldonado, Fabien Sinot, Cyril Mascolo, Ruddy Wattiez, Pascal Jean Lopez, Cécile Van de Weerdt, Matthew J. Harrington, Patrick Flammang
Publikováno v:
iScience, Vol 27, Iss 12, Pp 111443- (2024)
Summary: Mussels and tubeworms have evolved similar adhesive systems to cope with the hydrodynamics of intertidal environments. Both secrete adhesive proteins rich in DOPA, a post-translationally modified amino acid playing essential roles in their p
Externí odkaz:
https://doaj.org/article/1847ce0d53564a2f8e908b0ec740c607
Autor:
E. K. Fredrickson, W. S. D. Wilcock, M. J. Harrington, G. Cram, J. Tilley, D. Martin, J. Burnett
Publikováno v:
Earth and Space Science, Vol 11, Iss 11, Pp n/a-n/a (2024)
Abstract We present observations from two field deployments of a calibrated tiltmeter that we name the Self‐Calibrating Tilt Accelerometer (SCTA). The tiltmeter is based upon a triaxial quartz crystal accelerometer; the horizontal channels measure
Externí odkaz:
https://doaj.org/article/87a573ad61bf4a89b68e0892141b8842
Autor:
Dmitriy Zamarin, Diwakar Davar, Adel Samson, Kevin J Harrington, Siddharth Sheth, Eric Tu, Mitesh J Borad, Grace K Dy, Evanthia Galanis, Fernanda Arnaldez, Sandip P Patel, Nicholas Durham, Benedito A Carneiro, Sonia Agrawal, Zhongying Chen, Chunling Fan, Maozhen Gong, Jenny Burton, Kevin Laubscher
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 11 (2024)
Background MEDI5395 is a recombinant attenuated Newcastle disease virus engineered to express a human granulocyte-macrophage colony-stimulating factor transgene. Preclinically, MEDI5395 demonstrated broad oncolytic activity, augmented by concomitant
Externí odkaz:
https://doaj.org/article/9b8ca43a8d514a34aab835d920738e15
Autor:
Dáithí A. Stone, Christopher J. Noble, Greg E. Bodeker, Sam M. Dean, Luke J. Harrington, Suzanne M. Rosier, Graham D. Rye, Jordis S. Tradowsky
Publikováno v:
Earth's Future, Vol 12, Iss 9, Pp n/a-n/a (2024)
Abstract Cyclone Gabrielle passed along the northern coast of Aotearoa New Zealand in February 2023, producing historic rainfall accumulations and impacts. Gabrielle was an ex‐tropical cyclone that stalled and re‐energised off the north coast, re
Externí odkaz:
https://doaj.org/article/3c9b46f72b1042b99c86faa650bb5a60
Autor:
D. L. Schumacher, M. Zachariah, F. Otto, C. Barnes, S. Philip, S. Kew, M. Vahlberg, R. Singh, D. Heinrich, J. Arrighi, M. van Aalst, M. Hauser, M. Hirschi, V. Bessenbacher, L. Gudmundsson, H. K. Beaudoing, M. Rodell, S. Li, W. Yang, G. A. Vecchi, L. J. Harrington, F. Lehner, G. Balsamo, S. I. Seneviratne
Publikováno v:
Earth System Dynamics, Vol 15, Pp 131-154 (2024)
In the 2022 summer, western–central Europe and several other regions in the northern extratropics experienced substantial soil moisture deficits in the wake of precipitation shortages and elevated temperatures. Much of Europe has not witnessed a mo
Externí odkaz:
https://doaj.org/article/ea6d0dcff9b84f709c04d1f43d15a86c
Autor:
Victoria Jennings, Alan Melcher, Fiona Errington-Mais, Victoria Roulstone, Kevin J Harrington, Galabina Bozhanova, Shane Foo, Martin McLaughlin, Malin Pedersen, John Bell, Pablo Nenclares, Joan Kyula, Lizzie Appleton, Edward Armstrong, Masahiro Ono, Matthew K L Chiu, Anton Patrikeev, Nitya Mohan, Julia Hoebart, Emmanuel Patin
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 7 (2024)
Background Over the past decade, cancer immunotherapies have revolutionized the treatment of melanoma; however, responses vary across patient populations. Recently, baseline tumor size has been identified as an independent prognostic factor for overa
Externí odkaz:
https://doaj.org/article/2760efb5528c442eb6992610bc801ce3
Autor:
David Uriel Zamora Cisneros, Ziheng Wang, Noémie-Manuelle Dorval Courchesne, Matthew J. Harrington, Alejandro D. Rey
Publikováno v:
Frontiers in Soft Matter, Vol 4 (2024)
BackgroundLiquid crystal (LC) mesophases have an orientational and positional order that can be found in both synthetic and biological materials. These orders are maintained until some parameter, mainly the temperature or concentration, is changed, i
Externí odkaz:
https://doaj.org/article/63c5c02124a14aada50209eeee041118
Autor:
Gonzalo Rodriguez-Berriguete, Rathi Puliyadi, Nicole Machado, Alessandro Barberis, Remko Prevo, Martin McLaughlin, Francesca M. Buffa, Kevin J. Harrington, Geoff S. Higgins
Publikováno v:
Cell Death and Disease, Vol 15, Iss 1, Pp 1-10 (2024)
Abstract Immune checkpoint blockade (ICB) provides effective and durable responses for several tumour types by unleashing an immune response directed against cancer cells. However, a substantial number of patients treated with ICB develop relapse or
Externí odkaz:
https://doaj.org/article/5dbc7022b8d548e28086316032aa0121