Zobrazeno 1 - 10
of 820
pro vyhledávání: '"A. J. Hardcastle"'
Publikováno v:
Lifestyle Medicine, Vol 5, Iss 4, Pp n/a-n/a (2024)
ABSTRACT Primary Aim To describe the features of implementation in the setting of primary care (PC) for physical activity (PA) interventions that improved total and moderate to vigorous PA (MVPA). Secondary Aim To assess the scalability potential of
Externí odkaz:
https://doaj.org/article/b9582fd09e5e40e0bd3aea64234009be
Autor:
Suzanne E. de Bruijn, Daan M. Panneman, Nicole Weisschuh, Elizabeth L. Cadena, Erica G. M. Boonen, Lara K. Holtes, Galuh D. N. Astuti, Frans P. M. Cremers, Nico Leijsten, Jordi Corominas, Christian Gilissen, Anna Skowronska, Jessica Woodley, Andrew D. Beggs, Vasileios Toulis, Di Chen, Michael E. Cheetham, Alison J. Hardcastle, Terri L. McLaren, Tina M. Lamey, Jennifer A. Thompson, Fred K. Chen, John N. de Roach, Isabella R. Urwin, Lori S. Sullivan, Susanne Roosing
Publikováno v:
Frontiers in Genetics, Vol 15 (2024)
IntroductionAutosomal dominant retinitis pigmentosa type 17 (adRP, type RP17) is caused by complex structural variants (SVs) affecting a locus on chromosome 17 (chr17q22). The SVs disrupt the 3D regulatory landscape by altering the topologically asso
Externí odkaz:
https://doaj.org/article/4befa15848f34806ac97263fee8b70c9
Autor:
Christina Zarouchlioti, Stephanie Efthymiou, Stefano Facchini, Natalia Dominik, Nihar Bhattacharyya, Siyin Liu, Marcos Abreu Costa, Anita Szabo, Amanda N. Sadan, Albert S. Jun, Enrico Bugiardini, Henry Houlden, Andrea Cortese, Pavlina Skalicka, Lubica Dudakova, Kirithika Muthusamy, Michael E. Cheetham, Alison J. Hardcastle, Petra Liskova, Stephen J. Tuft, Alice E. Davidson
Publikováno v:
EBioMedicine, Vol 108, Iss , Pp 105328- (2024)
Summary: Background: Fuchs endothelial corneal dystrophy (FECD) is the most common repeat-mediated disease in humans. It exclusively affects corneal endothelial cells (CECs), with ≤81% of cases associated with an intronic TCF4 triplet repeat (CTG18
Externí odkaz:
https://doaj.org/article/886fb84cc1b04e459db16fc8c11e4f8d
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
BackgroundThe PPARCS trial examined the efficacy of a distance-based wearable and health coaching intervention to increase physical activity (PA) in breast and colorectal cancer (CRC) survivors living in non-metropolitan areas. This paper examines th
Externí odkaz:
https://doaj.org/article/f4e2ac6975c740bb9a3366d48ea55077
Autor:
Sarah J. Hardcastle, Chloe Maxwell-Smith, Vinicius Cavalheri, Terry Boyle, Marta Leyton Román, Cameron Platell, Michael Levitt, Christobel Saunders, Frank Sardelic, Sophie Nightingale, Jacob McCormick, Craig Lynch, Paul A. Cohen, Max Bulsara, Dana Hince
Publikováno v:
Journal of Sport and Health Science, Vol 13, Iss 1, Pp 81-89 (2024)
Background: Physical activity (PA) is important for cancer survivors. Trials of remotely delivered interventions are needed to assist in reaching under-served non-metropolitan cancer survivors. The objective of this study was to ascertain whether wea
Externí odkaz:
https://doaj.org/article/e8af35c3c561440bb553a49f258b4c98
Autor:
Nihar Bhattacharyya, Niuzheng Chai, Nathaniel J Hafford-Tear, Amanda N Sadan, Anita Szabo, Christina Zarouchlioti, Jana Jedlickova, Szi Kay Leung, Tianyi Liao, Lubica Dudakova, Pavlina Skalicka, Mohit Parekh, Ismail Moghul, Aaron R Jeffries, Michael E Cheetham, Kirithika Muthusamy, Alison J Hardcastle, Nikolas Pontikos, Petra Liskova, Stephen J Tuft, Alice E Davidson
Publikováno v:
PLoS Genetics, Vol 20, Iss 5, p e1011230 (2024)
Fuchs endothelial corneal dystrophy (FECD) is an age-related cause of vision loss, and the most common repeat expansion-mediated disease in humans characterised to date. Up to 80% of European FECD cases have been attributed to expansion of a non-codi
Externí odkaz:
https://doaj.org/article/2483dcb3baf447028431d996808cd5cd
Autor:
Ciara McCormack, Brona Kehoe, Sarah Cullivan, Noel McCaffrey, Sean Gaine, Brian McCullagh, Andrew McCarren, Sarah J. Hardcastle, Niall M. Moyna
Publikováno v:
ERJ Open Research, Vol 10, Iss 1 (2024)
Background Pulmonary hypertension (PH) is a heterogeneous condition, associated with a high symptom burden and a substantial loss of exercise capacity. Despite prior safety concerns regarding physical exertion, exercise training as a supportive thera
Externí odkaz:
https://doaj.org/article/0621a05c49f84f3aab184c1e3a64ea7e
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract The optokinetic nystagmus is a gaze-stabilizing mechanism reducing motion blur by rapid eye rotations against the direction of visual motion, followed by slower syndirectional eye movements minimizing retinal slip speed. Flies control their
Externí odkaz:
https://doaj.org/article/3ab8693bb9024623a9cdba3682be7eaf
Autor:
Ciara McCormack, Brona Kehoe, Sarah Cullivan, Noel McCaffrey, Sean Gaine, Brian McCullagh, Niall M. Moyna, Sarah J. Hardcastle
Publikováno v:
PLoS ONE, Vol 18, Iss 1 (2023)
Objective Physical activity (PA) is an established adjunct therapy for pulmonary hypertension (PH) patients to mitigate PH symptoms and improve quality of life. However, PA engagement within this population remains low. This study investigated PH pat
Externí odkaz:
https://doaj.org/article/d09d1c5190cf49a0b10555f84b1b0cc4
Autor:
Ciara McCormack, Sarah Cullivan, Brona Kehoe, Noel McCaffrey, Sean Gaine, Brian McCullagh, Niall M. Moyna, Sarah J. Hardcastle
Publikováno v:
Pulmonary Circulation, Vol 11, Iss 4, Pp 1-9 (2021)
Pulmonary hypertension is a progressive cardiorespiratory disease that is characterized by considerable morbidity and mortality. While physical activity can improve symptoms and quality of life, engagement in this population is suboptimal. The aim of
Externí odkaz:
https://doaj.org/article/7932184c1e574bfea1945d38638849eb