Zobrazeno 1 - 10
of 1 531
pro vyhledávání: '"A. J. Grootenhuis"'
Autor:
Jutta Glock, Peter D. J. Grootenhuis, Steven Bondy, Daniel D. Comer, Soan Cheng, Arthur Steiger, Martin Zeller, Grit Laue, Adrian Friedmann, Olivier Jacob, Mafalda Nina, Hans-Jürg Widmer, Klaus Kreuz, Julie E. Penzotti, Hans Brunner, James Allen, Thierry Niderman, Hans Ulrich Haas, Renold Chollet, Martin Eberle, Peter Renold, William Lutz, Jürg Ehrler, Marian Valentini, Markus Walti, Evelyne Sieger, Thomas Vettiger, G. Wayne Craig
Publikováno v:
CHIMIA, Vol 62, Iss 1-2 (2008)
The search for new active molecules with novel modes of action and desirable physical properties is an ongoing endeavour. This publication describes the follow-up chemistry of a biological hit discovered in the screening system of Novartis Crop Prote
Externí odkaz:
https://doaj.org/article/5c120d9f6ae7458abd6d1d641fce6442
Autor:
Jan N. M. Commandeur, Daan P. Geerke, Flemming Jørgensen, Ernst ter Haar, Arun K. Mohanty, Lars Olsen, Luigi Capoferri, Rasmus Leth, Peter D. J. Grootenhuis, Eduardo Vottero, Nico P. E. Vermeulen
Publikováno v:
Proteins: Structure, Function, and Bioinformatics. 84:383-396
Cytochrome P450 BM3 (CYP102A1) mutant M11 is able to metabolize a wide range of drugs and drug-like compounds. Among these, M11 was recently found to be able to catalyze formation of human metabolites of mefenamic acid and other nonsteroidal anti-inf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0327eadf855d73f43bf5c18993f8c2ed
https://doi.org/10.1002/prot.24985
https://doi.org/10.1002/prot.24985
Publikováno v:
2018 Medicinal Chemistry Reviews ISBN: 9780996293266
2018 Medicinal Chemistry Reviews
2018 Medicinal Chemistry Reviews
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::deee7cefe7ba8d46db26c255719b5c87
https://doi.org/10.29200/acsmedchemrev-v53.ch25
https://doi.org/10.29200/acsmedchemrev-v53.ch25
Autor:
Angelo J. Castellino, Peter D. J. Grootenhuis, Bondy Steven Scott, Mark J. Suto, Erin K. Bradley, Graham Beaton, Paul A. Gibbons, Michelle Lamb
Publikováno v:
Journal of Molecular Graphics and Modelling, 23(1), 15-21. Elsevier Inc.
Lamb, M L, Bradley, E K, Beaton, G, Bondy, S S, Castellino, A J, Gibbons, P A, Suto, M J & Grootenhuis, P D J 2004, ' Design of a gene family screening library targeting G-protein coupled receptors ', Journal of Molecular Graphics and Modelling, vol. 23, no. 1, pp. 15-21 . https://doi.org/10.1016/j.jmgm.2004.03.001
Lamb, M L, Bradley, E K, Beaton, G, Bondy, S S, Castellino, A J, Gibbons, P A, Suto, M J & Grootenhuis, P D J 2004, ' Design of a gene family screening library targeting G-protein coupled receptors ', Journal of Molecular Graphics and Modelling, vol. 23, no. 1, pp. 15-21 . https://doi.org/10.1016/j.jmgm.2004.03.001
An iterative process for the design of a G-protein coupled receptor (GPCR) gene family screening library has been developed. A key element of this process is the computational generation of pharmacophore descriptors of known GPCR ligands. Subsequent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5225afea9d1502b3e9f54452a380c295
https://research.vu.nl/en/publications/b595c063-9493-431d-bcb0-c7fa0956bef7
https://research.vu.nl/en/publications/b595c063-9493-431d-bcb0-c7fa0956bef7
Autor:
John Saunders, Jan N. M. Commandeur, Peter D. J. Grootenhuis, Nico P. E. Vermeulen, Jelle Reinen, Caroline Decker, Yongmin Li, Jolanda van Leeuwen, Lifang Sun
Publikováno v:
Drug Metabolism and Disposition. 39:1568-1576
In the present study, the diversity of a library of drug-metabolizing bacterial cytochrome P450 (P450) BM3 mutants was evaluated by a liquid chromatography-mass spectrometry (LC-MS)-based screening method. A strategy was designed to identify a minima
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0984d93607f7640bd35fa142122525a
https://doi.org/10.1124/dmd.111.039461
https://doi.org/10.1124/dmd.111.039461
Publikováno v:
Recueil des Travaux Chimiques des Pays-Bas. 112:161-168
The present paper evaluates the effect of several parameters on the accuracy of homology model-built structures of human thrombin. In order to appraise the merits of such a homology model-building study as a practical basis for direct drug-design pur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::303052a4a8bee55a552bac45f48eca44
https://doi.org/10.1002/recl.19931120214
https://doi.org/10.1002/recl.19931120214
Autor:
Mishra, Nigam M.1 (AUTHOR), Spitznagel, Brittany D.2 (AUTHOR), Du, Yu2,3 (AUTHOR), Mohamed, Yasmeen K.1 (AUTHOR), Qin, Ying1,4 (AUTHOR), Weaver, C. David2,3 (AUTHOR), Emmitte, Kyle A.1 (AUTHOR) kyle.emmitte@unthsc.edu
Publikováno v:
Molecules. Dec2024, Vol. 29 Issue 23, p5494. 19p.
Autor:
Alarilla, Anne1,2 (AUTHOR) anne.alarilla.16@ucl.ac.uk, Terrell, Katharine3 (AUTHOR), Kelly, Paula3 (AUTHOR), Chesters, Heather4 (AUTHOR), Gibson, Faith3,5 (AUTHOR), Oldham, Geralyn6 (AUTHOR), Sell, Debbie3 (AUTHOR), Davies, Gwyneth1,7 (AUTHOR), Wray, Jo3,8 (AUTHOR)
Publikováno v:
Systematic Reviews. 11/28/2024, Vol. 13 Issue 1, p1-41. 41p.
Autor:
Kusaczuk, Magdalena1 (AUTHOR) mkusaczuk@wp.pl, Tovar-Ambel, Elena2 (AUTHOR) elenatov@ucm.es, Martín-Cabrera, Paola2 (AUTHOR) paolmart@ucm.es, Lorente, Mar2 (AUTHOR) mmlorent@pdi.ucm.es, Salvador-Tormo, Nélida2 (AUTHOR) nsalvado@ucm.es, Mikłosz, Agnieszka3 (AUTHOR) agnieszka.miklosz@umb.edu.pl, Chabowski, Adrian3 (AUTHOR) adrian.chabowski@umb.edu.pl, Velasco, Guillermo2 (AUTHOR) gvelasco@ucm.es, Naumowicz, Monika4 (AUTHOR) mkusaczuk@wp.pl
Publikováno v:
International Journal of Molecular Sciences. Oct2024, Vol. 25 Issue 19, p10740. 19p.
Autor:
Bakhsh, Hadeel R.1 (AUTHOR) hrbakhsh@pnu.edu.sa, Aldhahi, Monira I.1 (AUTHOR) mialdhahi@pnu.edu.sa, Aldajani, Nouf S.1 (AUTHOR) 438001243@pnu.edu.sa, Davalji Kanjiker, Tahera Sultana2 (AUTHOR) taheradk@bu.edu, Bin Sheeha, Bodor H.1 (AUTHOR) bhbinsheeha@pnu.edu.sa, Alhasani, Rehab1 (AUTHOR)
Publikováno v:
Behavioral Sciences (2076-328X). Oct2024, Vol. 14 Issue 10, p916. 14p.