USP50 suppresses alternative RecQ helicase use and deleterious DNA2 activity during replication

Autor: Hannah L. Mackay, Helen R. Stone, George E. Ronson, Katherine Ellis, Alexander Lanz, Yara Aghabi, Alexandra K. Walker, Katarzyna Starowicz, Alexander J. Garvin, Patrick Van Eijk, Stefan A. Koestler, Elizabeth J. Anthony, Ann Liza Piberger, Anoop S. Chauhan, Poppy Conway-Thomas, Alina Vaitsiankova, Sobana Vijayendran, James F. Beesley, Eva Petermann, Eric J. Brown, Ruth M. Densham, Simon H. Reed, Felix Dobbs, Marco Saponaro, Joanna R. Morris

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)

Abstract Mammalian DNA replication relies on various DNA helicase and nuclease activities to ensure accurate genetic duplication, but how different helicase and nuclease activities are properly directed remains unclear. Here, we identify the ubiquiti

Externí odkaz: https://doaj.org/article/28ce5cbc0af0403c82bcaf2f474d55ce

SUMO monoclonal antibodies vary in sensitivity, specificity, and ability to detect types of SUMO conjugate

Autor: Alexander J. Garvin, Alexander J. Lanz, Joanna R. Morris

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-16 (2022)

Abstract Monoclonal antibodies (MAb) to members of the Small Ubiquitin-like modifier (SUMO) family are essential tools in the study of cellular SUMOylation. However, many anti-SUMO MAbs are poorly validated, and antibody matching to detection format

Externí odkaz: https://doaj.org/article/d494bb1fca2344f7b3ce0e21e3ff61c2

Parallel Line Sign—A New MRI Sign Associated With Chronic Sacroiliitis: Prevalence, Characteristics, and Associations

Autor: Timothy L. Miao, Shubreet Randhawa, Michael J. Roth, Yves Bureau, Joanne Howey, Gregory J. Garvin

Publikováno v: Canadian Association of Radiologists Journal. 73:647-654

Purpose: The purpose is to demonstrate the existence of the parallel line sign (PLS), a dark line parallel to the sacroiliac joint (SIJ), and determine its prevalence, characteristics, and associations. Methods: 200 consecutive SIJ MRIs referred by r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21a20a75539afdbd38ba1e8ff57b9603
https://doi.org/10.1177/08465371211069493

Intervertebral disc segmentation in MR images using anisotropic oriented flux

Autor: Law, Max W.K., Tay, KengYeow, Leung, Andrew, J. Garvin, Gregory, Li, Shuo

Publikováno v: In Medical Image Analysis January 2013 17(1):43-61

In Situ and Orbital Stratigraphic Characterization of the InSight Landing Site—A Type Example of a Regolith‐Covered Lava Plain on Mars

Autor: N. H. Warner, M. P. Golombek, V. Ansan, E. Marteau, N. Williams, J. A. Grant, E. Hauber, C. Weitz, S. Wilson, S. Piqueux, N. Mueller, M. Grott, T. Spohn, L. Pan, C. Schmelzbach, I. J. Daubar, J. Garvin, C. Charalambous, M. Baker, M. Banks

Publikováno v: Warner, N H, Golombek, M P, Ansan, V, Marteau, E, Williams, N, Grant, J A, Hauber, E, Weitz, C, Wilson, S, Piqueux, S, Mueller, N, Grott, M, Spohn, T, Pan, L, Schmelzbach, C, Daubar, I J, Garvin, J, Charalambous, C, Baker, M & Banks, M 2022, ' In Situ and Orbital Stratigraphic Characterization of the InSight Landing Site-A Type Example of a Regolith-Covered Lava Plain on Mars ', Journal of Geophysical Research: Planets, vol. 127, no. 4, e2022JE007232 . https://doi.org/10.1029/2022JE007232
Journal of Geophysical Research: Planets, 127 (4)

The InSight lander rests on a regolith-covered, Hesperian to Early Amazonian lava plain in Elysium Planitia within a ∼27-m-diameter, degraded impact crater called Homestead hollow. The km to cm-scale stratigraphy beneath the lander is relevant to t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::389d26909ffbae3704650a042a46baee
https://doi.org/10.1029/2022je007232