Výsledky vyhledávání - "A. J. FISCHMAN"

Akademický článek

Burn injury differentially alters whole-blood and organ glutathione synthesis rates: An experimental model

Autor: Zhe-Wei Fei, Vernon R Young, Xiao-Ming Lu, Andrew B Rhodes, Ronald G Tompkins, Alan J Fischman, Yong-Ming Yu

Publikováno v: Burns & Trauma, Vol 1, Iss 2, Pp 87-94 (2013)

Previous studies from our laboratories revealed a reduced rate of whole-blood (WB) glutathione (GSH) synthesis in severely burned patients. To determine whether WB GSH metabolism is an indicator of the status of GSH metabolism in one or more of the m

Externí odkaz: https://doaj.org/article/8b3d496470d443ec9d646049af30bbbd

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Akademický článek

Role of protein farnesylation in burn-induced metabolic derangements and insulin resistance in mouse skeletal muscle.

Autor: Harumasa Nakazawa, Marina Yamada, Tomokazu Tanaka, Joshua Kramer, Yong-Ming Yu, Alan J Fischman, J A Jeevendra Martyn, Ronald G Tompkins, Masao Kaneki

Publikováno v: PLoS ONE, Vol 10, Iss 1, p e0116633 (2015)

OBJECTIVE:Metabolic derangements, including insulin resistance and hyperlactatemia, are a major complication of major trauma (e.g., burn injury) and affect the prognosis of burn patients. Protein farnesylation, a posttranslational lipid modification

Externí odkaz: https://doaj.org/article/52ffc0e83e014b10845bffe620ce492d

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Akademický článek

Gram-Negative Bacterial Infection in Thigh Abscess Can Migrate to Distant Burn Depending on Burn Depth

Autor: Victoria Hamrahi, Michael R. Hamblin, Walter Jung, John B. Benjamin, Kasie W. Paul, Alan J. Fischman, Ronald G. Tompkins, Edward A. Carter

Publikováno v: Interdisciplinary Perspectives on Infectious Diseases, Vol 2012 (2012)

Sepsis remains the major cause of death in patients with major burn injuries. In the present investigation we evaluated the interaction between burn injuries of varying severity and preexisting distant infection. We used Gram-negative bacteria (Pseud

Externí odkaz: https://doaj.org/article/96caa12a2a564d84ba4808c613466b96

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Akademický článek

CNS penetration of intrathecal-lumbar idursulfase in the monkey, dog and mouse: implications for neurological outcomes of lysosomal storage disorder.

Autor: Pericles Calias, Mikhail Papisov, Jing Pan, Nancy Savioli, Vasily Belov, Yan Huang, Jason Lotterhand, Mary Alessandrini, Nan Liu, Alan J Fischman, Jan L Powell, Michael W Heartlein

Publikováno v: PLoS ONE, Vol 7, Iss 1, p e30341 (2012)

A major challenge for the treatment of many central nervous system (CNS) disorders is the lack of convenient and effective methods for delivering biological agents to the brain. Mucopolysaccharidosis II (Hunter syndrome) is a rare inherited lysosomal

Externí odkaz: https://doaj.org/article/911c03f9968a422186d2c2c26e3fc463

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Nutritional Regulation of Phenotypic Plasticity in a Solitary Bee (Hymenoptera: Megachilidae)

Autor: Brielle J. Fischman, Gene E. Robinson, Theresa L. Pitts-Singer

Publikováno v: Environmental Entomology. 46:1070-1079

Phenotypic plasticity involves adaptive responses to predictable environmental fluctuations and may promote evolutionary change. We studied the regulation of phenotypic plasticity in an important agricultural pollinator, the solitary alfalfa leafcutt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d914936936c0709322ab5bc7ed82aad6
https://doi.org/10.1093/ee/nvx119

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Akademický článek

Porcine Xenografts in Parkinson's Disease and Huntington's Disease Patients: Preliminary Results

Autor: J. Stephen Fink, James M. Schumacher, Samuel L. Ellias, E. Prather Palmer, Marie Saint-Hilaire, Kathleen Shannon, Richard Penn, Philip Starr, Craig Vanhorne, H. Stephen Kott M.D., Ph.D., Peter K. Dempsey, Alan J. Fischman, Ronald Raineri, Carolyn Manhart, Jonathan Dinsmore, Ole Isacson

Publikováno v: Cell Transplantation, Vol 9 (2000)

The observation that fetal neurons are able to survive and function when transplanted into the adult brain fostered the development of cellular therapy as a promising approach to achieve neuronal replacement for treatment of diseases of the adult cen

Externí odkaz: https://doaj.org/article/de6ee9c808c9450c8c89b0fb87edb67c

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Kidney and Liver Injuries After Major Burns in Rats Are Prevented by Resolvin D2

Autor: Rahmi Oklu, Tomohiro Kurihara, Daniel Irimia, Gaofeng Zhao, Amir Ibrahim, Anil V. Nair, Dennis Brown, Alan J. Fischman, Yoshitaka Inoue, Aleksandr Vasilyev, Ronald G. Tompkins, Yong Ming Yu

Publikováno v: Critical Care Medicine. 44:e241-e252

Objectives Innate immune dysfunction after major burn injuries increases the susceptibility to organ failure. Lipid mediators of inflammation resolution, e.g., resolvin D2, have been shown recently to restore neutrophil functionality and reduce morta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75d86aac3096bf0d36036f29f58a22c1
https://doi.org/10.1097/ccm.0000000000001397

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Genomic signatures of evolutionary transitions from solitary to group living

Autor: Robert M. Waterhouse, Daniela Puiu, Steven L. Salzberg, Robin F. A. Moritz, Eckart Stolle, Michael A. D. Goodisman, Evgeny M. Zdobnov, Seth M. Barribeau, Aarti Venkat, J. Spencer Johnston, Sarah D. Kocher, Carson Holt, Brendan G. Hunt, Francis M. F. Nunes, Daniel D. Ence, Jun Wang, Daniel Hamacher, Tanja Magoc, Saurabh Sinha, Martin Hasselmann, Gene E. Robinson, Brielle J. Fischman, Jay D. Evans, Cornelis J. P. Grimmelikhuijzen, Frank Hauser, Karen M. Kapheim, F. Bernhard Kraus, Jonathan Massey, Alvaro G. Hernandez, Daniel Guariz Pinheiro, E. D. Tanaka, Matthias Biewer, Mark Yandell, Guojie Zhang, Hugh M. Robertson, Michelle P.M. Soares, George D. Yocum, Klaus Hartfelder, Hailin Pan, Matthew E. Hudson, Karl M. Glastad, Clement F. Kent, Amro Zayed, Cai Li, Zilá Luz Paulino Simões, Reed M. Johnson, Charles Blatti, Jordi Bosch, William P. Kemp, Bruce R. Southey, Sophie Helbing, Shawn J. Hanrahan

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

For bees, many roads lead to social harmony Eusociality, where workers sacrifice their reproductive rights to support the colony, has evolved repeatedly and represents the most evolved form of social evolution in insects. Kapheim et al. looked across

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a5db10bd52975b40ba18e380d146233
https://doi.org/10.1126/science.aaa4788

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Simvastatin Reduces Burn Injury-induced Splenic Apoptosis via Downregulation of the TNF-α/NF-κB Pathway

Autor: Ali A. Bonab, Alan J. Fischman, Ronald G. Tompkins, Gaofeng Zhao, Masao Kaneki, Yong-Ming Yu

Publikováno v: Annals of Surgery. 261:1006-1012

Objective Recent studies have suggested that epidermal burn injuries are associated with inflammation and immune dysfunction. Simvastatin has been shown to possess potent anti-inflammatory properties. Thus, we hypothesized that simvastatin protects a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76069e9e0bc1d2c5b9369b46d5f60417
https://doi.org/10.1097/sla.0000000000000764

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