Zobrazeno 1 - 10 of 85 pro vyhledávání: '"A. J. Chubb"'
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Akademický článek
Recombinant PAPP-A resistant insulin-like growth factor binding protein 4 (dBP4) inhibits angiogenesis and metastasis in a murine model of breast cancer
Autor: Y. E. Smith, S. Toomey, S. Napoletano, G. Kirwan, C. Schadow, A. J. Chubb, J. H. Mikkelsen, C. Oxvig, J. H. Harmey
Publikováno v: BMC Cancer, Vol 18, Iss 1, Pp 1-12 (2018)
Abstract Background The Insulin-like growth factor (IGF) pathway plays a role in tumour development and progression. In vivo, IGF1 activity is regulated by the IGF binding proteins (IGFBPs). IGFBP4 inhibits the activity of IGF1 but proteolytic cleava
Externí odkaz: https://doaj.org/article/e82cd83a32274fc2a1c19804796792ca
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2
Integrated computational prediction and experimental validation identifies promiscuous T cell epitopes in the proteome of Mycobacterium bovis
Autor: Damien Farrell, Kerri M. Malone, Gareth Jones, Kevin Rue-Albrecht, Stephen V. Gordon, Martin Vordermeier, Chris Pirson, Anthony J. Chubb
Publikováno v: Microbial Genomics
The discovery of novel antigens is an essential requirement in devising new diagnostics or vaccines for use in control programmes against human tuberculosis (TB) and bovine tuberculosis (bTB). Identification of potential epitopes recognised by CD4+ T
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3bff3e04b2d0eb36e3d86369af72bc7
https://ora.ox.ac.uk/objects/uuid:81a4e374-5b51-4f25-9774-8ea86e3ba1a1
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3
Recombinant PAPP-A resistant insulin-like growth factor binding protein 4 (dBP4) inhibits angiogenesis and metastasis in a murine model of breast cancer
Autor: Claus Oxvig, Gemma Kirwan, C Schadow, Anthony J. Chubb, Sinead Toomey, Judith H. Harmey, Silvia Napoletano, Yvonne E. Smith, Jakob H. Mikkelsen
Publikováno v: BMC Cancer
Smith, Y E, Toomey, S, Napoletano, S, Kirwan, G, Schadow, C, Chubb, A J, Mikkelsen, J H, Oxvig, C & Harmey, J H 2018, ' Recombinant PAPP-A resistant insulin-like growth factor binding protein 4 (dBP4) inhibits angiogenesis and metastasis in a murine model of breast cancer ', BMC Cancer, vol. 18, 1016 . https://doi.org/10.1186/s12885-018-4950-0
BMC Cancer, Vol 18, Iss 1, Pp 1-12 (2018)
Background: The Insulin-like growth factor (IGF) pathway plays a role in tumour development and progression. In vivo, IGF1 activity is regulated by the IGF binding proteins (IGFBPs). IGFBP4 inhibits the activity of IGF1 but proteolytic cleavage by pr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::032f3636b768a1c67d76caeca68dae48
http://europepmc.org/articles/PMC6196427
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4
BAG3 promotes tumour cell proliferation by regulating EGFR signal transduction pathways in triple negative breast cancer
Autor: William M. Gallagher, David Matallanas, Emer Conroy, Amanda McCann, Judith A. Coppinger, Zivile Useckaite, Mark Ward, Tony O'Grady, Darran P. O'Connor, Rebecca Reilly, Eugene M. Dempsey, Anthony J. Chubb, Kate Connor, Alo McGoldrick, Sarah Shields, Elaine W. Kay, Yue Fan
Publikováno v: Oncotarget
// Sarah Shields 1 , Emer Conroy 1 , Tony O’Grady 5 , Alo McGoldrick 1 , Kate Connor 4 , Mark P. Ward 4 , Zivile Useckaite 4 , Eugene Dempsey 6 , Rebecca Reilly 1 , Yue Fan 1 , Anthony Chubb 4 , David Gomez Matallanas 2, 3 , Elaine W. Kay 5 , Darra
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c297538d6a1fb8a2506fa4403f8673f8
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6
Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond
Autor: Christopher D. Huston, Amornrat Naranuntarat Jensen, Louis Maes, Jordi Mestres, Nao Aki Watanabe, Michael Adsetts Edberg Hansen, Roberto Adelfio, Simon Townson, Didier Leroy, Kate Weatherby, Thomas Spangenberg, Manuela Carrasquilla, Kailash P. Patra, Robert E. Sinden, José Brea, Abhai K. Tripathi, W. Armand Guiguemde, Alan Y. Du, Melanie Wree, Katherine T. Andrews, Kirsten K. Hanson, Tyler B. Hughes, Sundari Suresh, Adele M. Lehane, Sangeeta N. Bhatia, Edward J. Wojcik, Andrew Hemphill, Francielly Morais Rodrigues da Costa, Worathad Chindaudomsate, Joseph M. Vinetz, Ben Gold, Sunyoung Kim, Edgar Vigil, Nuha R. Mansour, Mohamed Abdo Rizk, Patrick Valere Tsouh Fokou, Audrey Burton, Laran T. Jensen, David A. Fidock, Aishah Alsibaee, Filipe Silva Villela, Yesmalie Alemán Resto, Rajarshi Guha, Conor R. Caffrey, José A. Fernández Robledo, Thomas J. Ketas, Luke Mercer, Rob Hooft van Huijsduijnen, Maria Jose Lafuente, Wesley C. Van Voorhis, Lauve R. Y. Tchokouaha, Dee A. Carter, Anjo Theron, Benoît Laleu, Kiaran Kirk, Maurice A. Itoe, Robert P. St.Onge, Celia Quevedo, Andrea Ruecker, Paul Henri Amvam Zollo, Francisco-Javier Gamo, Nathan Lee, Alvine Ngoutane Mfopa, Paul Horrocks, Ikuo Igarashi, Nil Gural, Todd R. Golub, Gordana Panic, Jeremy N. Burrows, Phat Voong Vinh, Annette Kaiser, Fabrice Fekam Boyom, Pietro Alano, Anupam Pradhan, Sandra Duffy, Raj N. Misra, Vidya Prasanna Kumar, Aintzane Alday, Timothy N. C. Wells, María Isabel Loza, Sébastien Kicka, William J. Sullivan, Gregory M. Goldgof, Yo Suzuki, Yolanda Corbett, Sally-Ann Poulsen, Vida Ahyong, George Papadatos, Sujeevi Nawaratna, Rafaela Salgado Ferreira, Takaaki Horii, Imran Ullah, Nathalie Narraidoo, Natalie G. Robinett, Simon V. Avery, Grazia Camarda, Iset Medina Vera, Michael T. Ferdig, Fengwu Li, David Plouffe, Joseph L. DeRisi, Jasmeet Samra, Andreas Spitzmüller, Liqiong Liu, Christopher A. Rice, Thierry Soldati, Serge Maximilian Stamm, Suzanne Gokool, Beatrice L. Colon, Shimaa Abd El-Salam El-Sayed, Mark Baker, Kenneth O. Udenze, Na Le Dang, Katrin Ingram-Sieber, Dennis A. Smith, Rays H. Y. Jiang, Marian P. Brennan, Ani Galstian, Paul Willis, Dennis E. Kyle, Ainhoa Alzualde, Sarah Prats, Sheena McGowan, Vicky M. Avery, Jennifer Keiser, John P. Moore, Dalu Mancama, Gregory J. Crowther, Noemi Cowan, Maria B. Cassera, Valentin Trofimov, David Thomas, David J. Sullivan, Diana Ortiz, Nada Abla, S. Joshua Swamidass, Benjamin Blasco, Hoan Vu, Francesco Silvestrini, Anthony J. Chubb, Pamela M. White, Scott M. Landfear, Isabelle Florent, John H. Adams, Ronald J. Quinn, Andrew F. Wilks, Sandra March, Leonardo Lucantoni, Stephen Baker, Tana Bowling, Joachim Müller, Arantza Muriana, Lauren E. Boucher, Ajit Jadhav, Sukjun Lee, Elizabeth A. Winzeler, Choukri Ben Mamoun, Ulrich Schlecht, Daisy D. Colón-López, Marjorie Schmitt, Myles H. Akabas, Isabelle S Lucet, Stephen N. Hewitt, Naoaki Yokoyama, Carl Nathan, Bakela Nare, Cindy Vallières, Lotfi Bounaadja, Kayode K. Ojo, Wesley Wu, Ken Chih-Chien Cheng, Kathryn F. Tonissen, Michael J. Delves, Brian M. Suzuki, Aristea Lubar, Quentin D. Bickle, Stephan Meister, Silvia Parapini, Manuel Llinás, Ngoc Minh Pham, Seunghyun Moon, R. Kiplin Guy, Donatella Taramelli, Lawrence Ayong, Sarah D'Alessandro, Jürgen Bosch, David Little
Publikováno v: PLoS Pathogens, Vol 12, Iss 7, p e1005763 (2016)
Van Voorhis, Wesley C; Adams, John H; Adelfio, Roberto; Ahyong, Vida; Akabas, Myles H; Alano, Pietro; Alday, Aintzane; Alemán Resto, Yesmalie; Alsibaee, Aishah; Alzualde, Ainhoa; Andrews, Katherine T; Avery, Simon V; Avery, Vicky M; Ayong, Lawrence; Baker, Mark; Baker, Stephen; Ben Mamoun, Choukri; Bhatia, Sangeeta; Bickle, Quentin; Bounaadja, Lotfi; ... (2016). Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond. PLoS pathogens, 12(7), e1005763. Public Library of Science 10.1371/journal.ppat.1005763
PLoS Pathogens
PLoS Pathogens, Public Library of Science, 2016, 12 (7), pp.e1005763. ⟨10.1371/journal.ppat.1005763⟩
PLoS pathogens
Recercat. Dipósit de la Recerca de Catalunya
instname
PLOS
PLOS PATHOGENS
e1005763
PLOS Pathogens
PLOS Pathogens, Vol. 12, No 7 (2016) P. e1005763
A major cause of the paucity of new starting points for drug discovery is the lack of interaction between academia and industry. Much of the global resource in biology is present in universities, whereas the focus of medicinal chemistry is still larg
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed1aa7e406ea2a739a6d5c26550fa093
https://doaj.org/article/18b88a00726d44659ebd19c6f7c84d1b
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7
CycloPs: Generating Virtual Libraries of Cyclized and Constrained Peptides Including Nonnatural Amino Acids
Autor: Elise Bernard, Mélanie Verniere, Anthony J. Chubb, Denis C. Shields, Fergal J. Duffy, Marc Devocelle
Publikováno v: Journal of Chemical Information and Modeling. 51:829-836
We introduce CycloPs, software for the generation of virtual libraries of constrained peptides including natural and nonnatural commercially available amino acids. The software is written in the cross-platform Python programming language, and feature
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fc5dc51a948d5791953229a52bd5520
https://doi.org/10.1021/ci100431r
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8
Elucidating the role of Staphylococcus epidermidis serine–aspartate repeat protein G in platelet activation
Autor: Marian P. Brennan, Anthony J. Chubb, Timothy J. Foster, Marc Devocelle, S Arasu, Anthony Loughman, Dermot Cox
Publikováno v: Journal of Thrombosis and Haemostasis. 7:1364-1372
Summary. Background: Staphylococcus epidermidis is a commensal of the human skin that has been implicated in infective endocarditis and infections involving implanted medical devices. S. epidermidis induces platelet aggregation by an unknown mechanis
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f1fb0512254b604695ef9e5fbc90332
https://doi.org/10.1111/j.1538-7836.2009.03495.x
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9
Design and Evaluation of Antimalarial Peptides Derived from Prediction of Short Linear Motifs in Proteins Related to Erythrocyte Invasion
Autor: Ilias Stavropoulos, Nathalie Doolan, Catherine Mooney, Denis C. Shields, Angus Bell, Alessandra Bianchin, Darren B. Leneghan, Anthony J. Chubb
Publikováno v: PLoS ONE
PLoS ONE, Vol 10, Iss 6, p e0127383 (2015)
The purpose of this study was to investigate the blood stage of the malaria causing parasite, Plasmodium falciparum, to predict potential protein interactions between the parasite merozoite and the host erythrocyte and design peptides that could inte
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f5087e271dcb7355eb3d112d98bdbb8
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10
Cyclooxygenase-1 haplotype modulates platelet response to aspirin
Autor: Ciara Dolan, John T. O'Brien, Denis C. Shields, Desmond J. Fitzgerald, Andrew O. Maree, Anthony J. Chubb, Peter Crean, Dermot Cox, Ronan Curtin
Publikováno v: Journal of Thrombosis and Haemostasis. 3:2340-2345
Summary. Background: Aspirin (acetylsalicylic acid) irreversibly inhibits platelet cyclooxygenase (COX)-1, the enzyme that converts arachidonic acid (AA) to the potent platelet agonist thromboxane (TX) A2. Despite clear benefit from aspirin in patien
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e631228af95710022398c68c148114c
https://doi.org/10.1111/j.1538-7836.2005.01555.x
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