Zobrazeno 1 - 10
of 1 551
pro vyhledávání: '"A. J. Cairns"'
Autor:
William R. Reay, Dylan J. Kiltschewskij, Maria A. Di Biase, Zachary F. Gerring, Kousik Kundu, Praveen Surendran, Laura A. Greco, Erin D. Clarke, Clare E. Collins, Alison M. Mondul, Demetrius Albanes, Murray J. Cairns
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract Retinol is a fat-soluble vitamin that plays an essential role in many biological processes throughout the human lifespan. Here, we perform the largest genome-wide association study (GWAS) of retinol to date in up to 22,274 participants. We i
Externí odkaz:
https://doaj.org/article/0c655eee8d4849408b87c1536766268d
Publikováno v:
Open Heart, Vol 10, Iss 2 (2023)
Objective Cardiovascular multimorbidity (CVM) is the co-occurrence of multiple cardiovascular disease subtypes (CVDs) in one person. Because common patterns and incidence of CVM are not well-described, particularly in women, we conducted a descriptiv
Externí odkaz:
https://doaj.org/article/121a1f33e24f465eafb6953efd891b6c
Publikováno v:
npj Digital Medicine, Vol 6, Iss 1, Pp 1-18 (2023)
Abstract The recent availability of electronic health records (EHRs) have provided enormous opportunities to develop artificial intelligence (AI) algorithms. However, patient privacy has become a major concern that limits data sharing across hospital
Externí odkaz:
https://doaj.org/article/0796d19e639b4be294e66493b0931ded
Autor:
Behnaz Khavari, Michelle M. Barnett, Ebrahim Mahmoudi, Michael P. Geaghan, Adam Graham, Murray J. Cairns
Publikováno v:
Life, Vol 14, Iss 5, p 562 (2024)
Oxidative stress is one of the most important environmental exposures associated with psychiatric disorders, but the underlying molecular mechanisms remain to be elucidated. In a previous study, we observed a substantial alteration of the gene expres
Externí odkaz:
https://doaj.org/article/8067494e375d48fa9d286adefe0c8708
Autor:
Min Su, Tao Pan, Qiu-Zhen Chen, Wei-Wei Zhou, Yi Gong, Gang Xu, Huan-Yu Yan, Si Li, Qiao-Zhen Shi, Ya Zhang, Xiao He, Chun-Jie Jiang, Shi-Cai Fan, Xia Li, Murray J. Cairns, Xi Wang, Yong-Sheng Li
Publikováno v:
Military Medical Research, Vol 9, Iss 1, Pp 1-24 (2022)
Abstract The application of single-cell RNA sequencing (scRNA-seq) in biomedical research has advanced our understanding of the pathogenesis of disease and provided valuable insights into new diagnostic and therapeutic strategies. With the expansion
Externí odkaz:
https://doaj.org/article/fc9db80245b2472a877d6165c2a2a837
Publikováno v:
Translational Psychiatry, Vol 12, Iss 1, Pp 1-9 (2022)
Abstract Almost half of individuals diagnosed with schizophrenia also present with a substance use disorder, however, little is known about potential molecular mechanisms underlying this comorbidity. We used genetic analyses to enhance our understand
Externí odkaz:
https://doaj.org/article/24324cca5f6c40e499d166603c3d1256
Publikováno v:
Translational Psychiatry, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Psychiatric disorders such as schizophrenia are commonly associated with structural brain alterations affecting the cortex. Recent genetic evidence suggests circulating metabolites and other biochemical traits play a causal role in many psyc
Externí odkaz:
https://doaj.org/article/1fcff63a6e2b4238b0b84498790b36e9
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Susceptibility to pneumonia has a genetic component, but specific genes involved remain poorly understood. In this study, genetic signals associated with pneumonia susceptibility are identified, providing information about disease biology and potenti
Externí odkaz:
https://doaj.org/article/b1b60a51cd964f04b60d6c7905cc9091
Autor:
TienYu Owen Yang, Benjamin J. Cairns, Kirstin Pirie, Jane Green, Valerie Beral, Sarah Floud, Gillian K. Reeves
Publikováno v:
BMC Cancer, Vol 22, Iss 1, Pp 1-9 (2022)
Abstract Background Greater early life adiposity has been reported to reduce postmenopausal breast cancer risk but it is unclear whether this association varies by tumour characteristics. We aimed to assess associations of early life body size with p
Externí odkaz:
https://doaj.org/article/d3c290c49b564d2a91074ae36e993713
Autor:
Rebecca L. Miller, Dhruva D. Dhavale, Jennifer Y. O’Shea, Kristin M. Andruska, Jialu Liu, Erin E. Franklin, Chandana Buddhala, Susan K. Loftin, John R. Cirrito, Richard J. Perrin, Nigel J. Cairns, Meghan C. Campbell, Joel S. Perlmutter, Paul T. Kotzbauer
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 9, Iss 2, Pp 106-121 (2022)
Abstract Objective Parkinson disease (PD) is defined by the accumulation of misfolded α‐synuclein (α‐syn) in Lewy bodies and Lewy neurites. It affects multiple cortical and subcortical neuronal populations. The majority of people with PD develo
Externí odkaz:
https://doaj.org/article/5d4c609a4ab746119c1a7b2d88db2bf2