Zobrazeno 1 - 7
of 7
pro vyhledávání: '"A. J. A. Groffen"'
Autor:
M. H. S. Deurloo, S. Eide, E. Turlova, Q. Li, S. Spijker, H.-S. Sun, A. J. A. Groffen, Z.-P. Feng
Publikováno v:
Cell & Bioscience, Vol 14, Iss 1, Pp 1-20 (2024)
Abstract Background Rasal1 is a Ras GTPase-activating protein which contains C2 domains necessary for dynamic membrane association following intracellular calcium elevation. Membrane-bound Rasal1 inactivates Ras signaling through its RasGAP activity,
Externí odkaz:
https://doaj.org/article/2da25e7868e54f789515c275a64871b6
Autor:
Aygul Subkhangulova, Miguel A. Gonzalez-Lozano, Alexander J. A. Groffen, Jan R. T. van Weering, August B. Smit, Ruud F. Toonen, Matthijs Verhage
Tomosyn is a large, non-canonical SNARE protein proposed to act as a competitive inhibitor of SNARE complex formation in vesicle exocytosis. In the brain, tomosyn inhibits fusion of synaptic vesicles (SVs), whereas its role in the fusion of neuropept
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::05abb6bf6d0dd1a5a2687f58508195b0
https://doi.org/10.1101/2022.12.18.520925
https://doi.org/10.1101/2022.12.18.520925
Autor:
Cornelia J Geerts, Roberta Mancini, Ning Chen, Frank T W Koopmans, Ka Wan Li, August B Smit, Jan R T van Weering, Matthijs Verhage, Alexander J A Groffen
Publikováno v:
PLoS ONE, Vol 12, Iss 7, p e0180912 (2017)
The secretory pathway in neurons requires efficient targeting of cargos and regulatory proteins to their release sites. Tomosyn contributes to synapse function by regulating synaptic vesicle (SV) and dense-core vesicle (DCV) secretion. While there is
Externí odkaz:
https://doaj.org/article/aaa47e4ef143401f9fd51374439a4dba
Autor:
Cornelia J Geerts, Linda Jacobsen, Rhea van de Bospoort, Matthijs Verhage, Alexander J A Groffen
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e91697 (2014)
Protein modification by Small Ubiquitin-like MOdifier (SUMO) entities is involved in a number of neuronal functions, including synaptogenesis and synaptic plasticity. Tomosyn-1 (syntaxin-binding protein 5; STXPB5) binds to t-SNARE (Soluble NSF Attach
Externí odkaz:
https://doaj.org/article/a8d4558d20fe499abc8e5d19b602154d
Publikováno v:
PLoS ONE, Vol 6, Iss 11, p e28137 (2011)
The serotonin (5-HT) system densely innervates many brain areas and is important for proper brain development. To specifically ablate the 5-HT system we generated mutant mice carrying a floxed Munc18-1 gene and Cre recombinase driven by the 5-HT-spec
Externí odkaz:
https://doaj.org/article/7c9b0dc066444fa685349e5d3197cd79
Publikováno v:
Journal of neurochemistry. 97(3)
Elevation of the intracellular calcium concentration ([Ca2+]i) to levels below 1 microm alters synaptic transmission and induces short-term plasticity. To identify calcium sensors involved in this signalling, we investigated soluble C2 domain-contain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5091857aa75a72bb2703ddcd6c20ef00
https://pubmed.ncbi.nlm.nih.gov/16515538
https://pubmed.ncbi.nlm.nih.gov/16515538
Autor:
J. W. M. Martens, H. J. Bosch, A. J. A. Groffen, M. Knoester, F. Weyts, J. M. Vlak, Bert Visser
Publikováno v:
Plant Production on the Threshold of a New Century ISBN: 9789401045056
Baculoviruses are insect pathogens that cause fatal disease in many Lepidopteran larvae. The major drawback in the use of these viruses as biological insect control agents is their slow speed of action. Improvement of this property is sought by intro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8adb694ab72aafc14d6beab0539f4782
https://doi.org/10.1007/978-94-011-1158-4_50
https://doi.org/10.1007/978-94-011-1158-4_50