Zobrazeno 1 - 10
of 44
pro vyhledávání: '"A. J Murrills"'
Autor:
Richard J. Murrills, Miles D. Houslay, Sheree F. Logue, May Tam, Cody Kelley, Thomas A. Comery, Steven M. Grauer, Jason M. Dwyer, Julie A. Brennan, Rachel Navarra, Michael J. Agostino, Virginia L. Pulito, Jonathon P. Day, Li-Xin Jiang, Sarah J. Neal, Nicholas J. Brandon, Brian J. Platt, Stacey J. Sukoff Rizzo, Subha Lakkaraju, Xiaotian Zhong, Michy P. Kelly
Publikováno v:
Proceedings of the National Academy of Sciences. 107:8457-8462
Phosphodiesterase 11A (PDE11A) is the most recently identified family of phosphodiesterases (PDEs), the only known enzymes to break down cyclic nucleotides. The tissue expression profile of this dual specificity PDE is controversial, and little is un
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6791ec648280e9a0a701d844a9352cb
https://doi.org/10.1073/pnas.1000730107
https://doi.org/10.1073/pnas.1000730107
Autor:
Weiguang Zhao, Raymond Unwalla, Frederick J. Bex, Richard J. Murrills, John A. Robinson, Nippa Alon, Usha Varadarajan, Paul J. Yaworsky, Adam M. Gilbert, Valerie E. Coleburn, Virginia Gironda, Diane B. Hauze, Matthew Kirisits, Michael C. Sharp, Paula Green, Yao-Bin Liu, Yogendra P. Kharode, Girija Krishnamurthy, Matthew Gregory Bursavich, Bheem M. Bhat, Michael Cain, Sabrina Lombardi, Jeanne J. Matteo, Sally Selim, Ho-Sun Lam
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:366-370
A series of (hetero)arylpyrimidines agonists of the Wnt-beta-catenin cellular messaging system have been prepared. These compounds show activity in U2OS cells transfected with Wnt-3a, TCF-luciferase, Dkk-1 and tk-Renilla. Selected compounds show mini
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf51cfbc58bde75044a12e24b5e0086f
https://doi.org/10.1016/j.bmcl.2009.10.093
https://doi.org/10.1016/j.bmcl.2009.10.093
Publikováno v:
Journal of Bone and Mineral Research. 7:415-423
The role of protein kinase C in the regulation of osteoclast function is not known. We therefore compared the effect of phorbol myristate acetate (PMA), which activates protein kinase C, on the resorptive function, motility, and morphology of osteocl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f898493599689e206c3d75ada9b199d0
https://doi.org/10.1002/jbmr.5650070409
https://doi.org/10.1002/jbmr.5650070409
Publikováno v:
Journal of Bone and Mineral Research. 4:259-268
Human osteoclasts were isolated from 12- to 17-week-old fetal tissue and from transiliac crest bone biopsies for an in vitro study of their biology. A hypodermic needle was used to flush either the fetal long bones or the trabeculae of the iliac cres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5cd525c7e41a78a1a13a68b83efa65f
https://doi.org/10.1002/jbmr.5650040219
https://doi.org/10.1002/jbmr.5650040219
Autor:
Diane B. Hauze, Michael C. Sharp, Bheem M. Bhat, Paula Green, Colleen Milligan, Daniel M. Green, Jennifer Pirrello, Peter V.N. Bodine, Ronald L. Magolda, Adam M. Gilbert, Matthew D. Vera, Yogendra P. Kharode, Valerie E. Coleburn, Luciana De Araujo Felix, Mattew G. Bursavich, Nipa Alon, Jeanne J. Matteo, Jay Wrobel, Frederick J. Bex, Jeffrey C. Pelletier, Susan Lockhead, Joseph T. Lundquist, Richard J. Murrills, Ray Unwalla, Paul J. Yaworsky, Sally Selim, John F. Mehlmann, Ho-Sun Lam
Publikováno v:
Journal of Medicinal Chemistry. 52:6962-6965
A high-throughput screening campaign to discover small molecule leads for the treatment of bone disorders concluded with the discovery of a compound with a 2-aminopyrimidine template that targeted the Wnt beta-catenin cellular messaging system. Hit-t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26eacb52fff02ace8eb134ea084fe282
https://doi.org/10.1021/jm9014197
https://doi.org/10.1021/jm9014197
Autor:
Ramesh A. Bhat, Rachelle L. Samuel, Jennifer L. Andrews, Peter V.N. Bodine, Frederick J. Bex, Valerie E. Coleburn, Richard J. Murrills, Bheem M. Bhat
Publikováno v:
Journal of Cellular Biochemistry. 106:887-895
Parathyroid hormone (PTH) activates multiple signaling pathways following binding to the PTH1 receptor in osteoblasts. Previous work revealed a discrepancy between cAMP stimulation and CRE reporter activation of truncated PTH peptides, suggesting tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffbd8ae7072806e8e44d9f5e416325cb
https://doi.org/10.1002/jcb.22057
https://doi.org/10.1002/jcb.22057
Autor:
Richard J. Murrills
Publikováno v:
Clinical Reviews in Bone and Mineral Metabolism. 4:233-258
Parathyroid hormone has dual effects on bone cells, stimulating both bone resorption and bone formation. Almost all of the known effects of PTH on bone cells appear to be mediated through the PTH1 receptor (PTHR1). PTHR1 is found on several different
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bf66116ce333ad174d3ed44625d1f789
https://doi.org/10.1385/bmm:4:4:233
https://doi.org/10.1385/bmm:4:4:233
Autor:
Kees Kenneth L, Valerie E. Coleburn, Frederick J. Bex, Horace Fletcher, Bheem M. Bhat, Jeanne J. Matteo, Richard J. Murrills, Charles William Mann, Diane B. Hauze
Publikováno v:
Letters in Drug Design & Discovery. 2:201-204
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aa51cedc0eef3cefda7e99a59354d7cd
https://doi.org/10.2174/1570180053765110
https://doi.org/10.2174/1570180053765110
Autor:
Jeanne J. Matteo, Valerie E. Coleburn, Bheem M. Bhat, Rachelle L. Samuel, Richard J. Murrills, Yogendra P. Kharode, Jennifer L. Andrews, Frederick J. Bex
Publikováno v:
Bone. 35:1263-1272
There is considerable evidence implicating the cAMP-signaling pathway in the anabolic action of PTH; and to date, all PTH and PTHrp peptides that stimulate cyclic AMP are active in animal models of osteogenesis. We have tested two C-terminally trunca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f891e82c05796a3a4a7dfc0bf268918a
https://doi.org/10.1016/j.bone.2004.08.015
https://doi.org/10.1016/j.bone.2004.08.015
Autor:
Fred Bex, John P. Bilezikian, Richard J. Murrills, Hong Gao, Stephen A. Morris, Peter V.N. Bodine
Publikováno v:
Journal of Cellular Physiology. 193:10-18
Parathyroid hormone (PTH) sensitive adenylyl cyclase activity (ACA) in SaOS-2 cells varies as a function of cell passage. In early passage (EP) cells (6), ACA in response to PTH and forskolin (FOR) was relatively low and equivalent, whereas in late p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0885f22e0776eba5363460577ea0cc1
https://doi.org/10.1002/jcp.10141
https://doi.org/10.1002/jcp.10141