Autophagy and Cancer

Autor: Vincenzo Giansanti, Luis Miguel Guamán Ortiz, Francesca Aredia, A. Ivana Scovassi

Publikováno v: Cells, Vol 1, Iss 3, Pp 520-534 (2012)

Autophagy is a housekeeping survival mechanism with a protective function against stress conditions. However, when stress severity or duration increases, it may promote cell death. Paradoxically, autophagy favors cancer development, since cancer cell

Externí odkaz: https://doaj.org/article/7f0fe0c0b09643108995e38f8ae578a9

Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead

Autor: Dustin G. Brown, Tove Hultman, Judith Weisz, H. Kim Lyerly, Paola A. Marignani, Ann-Karin Olsen, Rabindra Roy, Kim Moorwood, Masoud H. Manjili, Monica Vaccari, Jesse Roman, Hasiah Ab Hamid, Kalan R. Prudhomme, Periyadan K. Krishnakumar, Chenfang Dong, Tiziana Guarnieri, Leandro S. D'Abronzo, Gloria M. Calaf, Amelia K Charles, Emanuela Corsini, Yunus A. Luqmani, Graeme Williams, Louis Vermeulen, Pankaj Vadgama, Sarah N Bay, Véronique Maguer-Satta, Sabine A. S. Langie, Christian C. Naus, Le Jian, Gladys N. Nangami, Lorenzo Memeo, Stephanie C. Casey, Thomas Sanderson, Takemi Otsuki, Nichola Cruickshanks, William H. Bisson, Sudjit Luanpitpong, Jonathan Whitfield, Ahmed Lasfar, Yon Rojanasakul, A. Ivana Scovassi, Shelley A. Harris, Ferdinando Chiaradonna, Richard Ponce-Cusi, Gregory T. Wolf, Valérian Dormoy, Roslida Abd Hamid, Hyun Ho Park, Matilde E. Lleonart, William K. Decker, Maria Romano, Leroy Lowe, Fabio Marongiu, Jan Vondráček, Chiara Mondello, Luc Leyns, Josiah Ochieng, Pratima Nangia-Makker, Edward A. Ratovitski, Zhiwei Hu, Jayadev Raju, Hemad Yasaei, Rafaela Andrade-Vieira, Jordan Woodrick, Hideko Sone, Harini Krishnan, W. Kimryn Rathmell, Andrew Collins, Luoping Zhang, Barry J. Barclay, Amaya Azqueta, Laura Soucek, Marc A. Williams, David O. Carpenter, Roberta Palorini, Rita Nahta, Juan Fernando Martinez-Leal, Firouz Darroudi, Rita Dornetshuber-Fleiss, James E. Klaunig, Elizabeth P. Ryan, Qiang Shawn Cheng, Arthur Berg, Andrew Ward, Gudrun Koppen, Tao Chen, Petr Heneberg, Michael Gilbertson, Amedeo Amedei, Sakina E. Eltom, Ezio Laconi, Joseph Christopher, Hiroshi Kondoh, Neetu Singh, Danielle J Carlin, Marion Chapellier, Michalis V. Karamouzis, Rekha Mehta, Tae-Jin Lee, Annamaria Colacci, Venkata S. Sabbisetti, Mark Wade, Micheline Kirsch-Volders, Patricia Ostrosky-Wegman, Isabelle R. Miousse, Patricia A. Thompson, Philippa D. Darbre, Frederik J. van Schooten, Sofia Pavanello, Igor Koturbash, Binhua P. Zhou, Ranjeet Kumar Sinha, Anna C. Salzberg, Mahara Valverde, Fahd Al-Mulla, Julia Kravchenko, Nicole Kleinstreuer, Carolyn J. Baglole, Menghang Xia, Samira A. Brooks, Amancio Carnero, Gunnar Brunborg, Sandra S. Wise, Daniel C. Koch, John Pierce Wise, Rabeah Al-Temaimi, Laetitia Gonzalez, Lisa J. McCawley, R. Brooks Robey, Gary S. Goldberg, Thierry Massfelder, Linda S M Gulliver, Olugbemiga Ogunkua, Emilio Rojas, Eun-Yi Moon, Lin Li, Silvana Papagerakis, Nik van Larebeke, Adela Lopez de Cerain Salsamendi, Staffan Eriksson, Simona Romano, Dean W. Felsher, Paramita M. Ghosh, Karine A. Cohen-Solal, Paul Dent, Jun Sun, Carmen Blanco-Aparicio, Riccardo Di Fiore, Chia-Wen Hsu, Mahin Khatami, Kannan Badri Narayanan, Francis Martin, Colleen S. Curran, Dale W. Laird, William H. Goodson, Abdul Manaf Ali, Valerie Odero-Marah, Michael J. Gonzalez, Renza Vento, Liang Tzung Lin, Clement G. Yedjou, Hosni Salem, Hsue-Yin Hsu, Zhenbang Chen, Nuzhat Ahmed, Gerard Wagemaker, Sandra Ryeom, Stefano Forte, Debasish Roy, Nancy B. Kuemmerle, Robert C. Castellino, Po Sing Leung, Wilhelm Engström

Publikováno v: Carcinogenesis, 36 Suppl 1, S254-S296. Oxford University Press
Carcinogenesis
Carcinogenesis, Oxford University Press (OUP), 2015, 36 (Suppl 1), pp.S254-96. ⟨10.1093/carcin/bgv039⟩
Carcinogenesis, 2015, 36 (Suppl 1), pp.S254-96. ⟨10.1093/carcin/bgv039⟩
Digital.CSIC. Repositorio Institucional del CSIC
instname

Goodson, William H. et al.
© The Author 2015. Lifestyle factors are responsible for a considerable portion of cancer incidence worldwide, but credible estimates from the World Health Organization and the International Agency for Research on Can

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5823ab67c1d978d35e01104f2396538
https://doi.org/10.1093/carcin/bgv039

Manipulation of Intracellular pH in Cancer Cells by NHE1 Inhibitors

Autor: Anna Ivana Scovassi, Francesca Aredia

Publikováno v: Protein & Peptide Letters. 23:1123-1129

Cancer cells are characterized by a peculiar pH condition, being the extracellular compartment acidic and the intracellular one neutral or basic, i.e. the opposite of what happens in normal cells. The reversal of the pH contributes to cancer cell pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a56936b72f7774a262d9276f0e5275e
https://doi.org/10.2174/0929866523666161013125536

An Innovative Cell Microincubator for Drug Discovery Based on 3D Silicon Structures

Autor: Giuliano Mazzini, Salvatore Surdo, Anna Ivana Scovassi, F. Carpignano, Francesca Aredia, Giuseppe Barillaro, Sabina Merlo

Publikováno v: Journal of Nanomaterials, Vol 2016 (2016)

We recently employed three-dimensional (3D) silicon microstructures (SMSs) consisting in arrays of 3 μm-thick silicon walls separated by 50 μm-deep, 5 μm-wide gaps, as microincubators for monitoring the biomechanical properties of tumor cells. The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::768f83867641d8d1af8017a347a4409f
https://doi.org/10.1155/2016/8236539

The impact of low-dose carcinogens and environmental disruptors on tissue invasion and metastasis

Autor: Lorenzo Memeo, A. Ivana Scovassi, Chenfang Dong, Yunus A. Luqmani, Jayadev Raju, Jordan Woodrick, Pratima Nangia-Makker, Chiara Mondello, Josiah Ochieng, Hosni Salem, Rabeah Al-Temaimi, Zhenbang Chen, Nuzhat Ahmed, Annamaria Colacci, Igor Koturbash, Monica Vaccari, Dustin G. Brown, Roslida Abd Hamid, Silvana Papagerakis, Amedeo Amedei, Gregory T. Wolf, Stefano Forte, William H. Bisson, Sakina E. Eltom, Gladys N. Nangami, Neetu Singh, Fahd Al-Mulla, Rabindra Roy, Olugbemiga Ogunkua, Lisa J. McCawley, Valerie Odero-Marah, Isabelle R. Miousse, Elizabeth P. Ryan, Binhua P. Zhou

Publikováno v: Carcinogenesis. 36:S128-S159

The purpose of this review is to stimulate new ideas regarding low-dose environmental mixtures and carcinogens and their potential to promote invasion and metastasis. Whereas a number of chapters in this review are devoted to the role of low-dose env

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::435ef308e5bc88953c315656bfeda9fb
https://doi.org/10.1093/carcin/bgv034