Zobrazeno 1 - 10
of 589
pro vyhledávání: '"A. Iraolagoitia"'
Autor:
Pooyeh Farahmand, Katarina Gyuraszova, Claire Rooney, Ximena L. Raffo-Iraolagoitia, Geeshath Jayasekera, Ann Hedley, Emma Johnson, Tatyana Chernova, Gaurav Malviya, Holly Hall, Tiziana Monteverde, Kevin Blyth, Rodger Duffin, Leo M. Carlin, David Lewis, John Le Quesne, Marion MacFarlane, Daniel J. Murphy
Publikováno v:
Frontiers in Toxicology, Vol 5 (2023)
Hypothesis: Asbestos-driven inflammation contributes to malignant pleural mesothelioma beyond the acquisition of rate-limiting mutations.Methods: Genetically modified conditional allelic mice that were previously shown to develop mesothelioma in the
Externí odkaz:
https://doaj.org/article/22a89dde7a66402e9f39b70b94fa6332
Autor:
Florencia Secchiari, Sol Yanel Nuñez, Jessica Mariel Sierra, Andrea Ziblat, María Victoria Regge, Ximena Lucía Raffo Iraolagoitia, Agustín Rovegno, Carlos Ameri, Fernando Pablo Secin, Nicolás Richards, Hernando Ríos Pita, Gonzalo Vitagliano, Luis Rico, Mauro Mieggi, Florencia Frascheri, Nicolás Bonanno, Leandro Blas, Aldana Trotta, Adrián David Friedrich, Mercedes Beatriz Fuertes, Carolina Inés Domaica, Norberto Walter Zwirner
Publikováno v:
OncoImmunology, Vol 11, Iss 1 (2022)
NKG2D is a major natural killer (NK) cell-activating receptor that recognizes eight ligands (NKG2DLs), including MICA, and whose engagement triggers NK cell effector functions. As NKG2DLs are upregulated on tumor cells but tumors can subvert the NKG2
Externí odkaz:
https://doaj.org/article/1adb248fdaf140c9b28258767763461f
Autor:
Jessica M. Sierra, Florencia Secchiari, Sol Y. Nuñez, Ximena L. Raffo Iraolagoitia, Andrea Ziblat, Adrián D. Friedrich, María V. Regge, M. Cecilia Santilli, Nicolás I. Torres, Mariana Gantov, Aldana Trotta, Carlos Ameri, Gonzalo Vitagliano, Hernando Ríos Pita, Luis Rico, Agustín Rovegno, Nicolás Richards, Carolina I. Domaica, Norberto W. Zwirner, Mercedes B. Fuertes
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Natural Killer (NK) cells play a key role in cancer immunosurveillance. However, NK cells from cancer patients display an altered phenotype and impaired effector functions. In addition, evidence of a regulatory role for NK cells is emerging in divers
Externí odkaz:
https://doaj.org/article/3d8fa6bbe2054f3f9321c991e500c96a
Autor:
Andrea Ziblat, Ximena Lucía Raffo Iraolagoitia, Sol Yanel Nuñez, Nicolás Ignacio Torres, Florencia Secchiari, Jessica Mariel Sierra, Raúl Germán Spallanzani, Agustín Rovegno, Fernando Pablo Secin, Mercedes Beatriz Fuertes, Carolina Inés Domaica, Norberto Walter Zwirner
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Although natural killer (NK) cells infiltrate clear cell renal cell carcinomas (ccRCC), the most frequent malignancy of the kidney, tumor progression suggests that they become dysfunctional. As ccRCC-driven subversion of NK cell effector functions is
Externí odkaz:
https://doaj.org/article/7fcc502be5bf4a60b9407ff51b56cfca
Autor:
Kenneth W Hance, Nicolas Torres, María Victoria Regge, Florencia Secchiari, Adrián David Friedrich, Raúl Germán Spallanzani, Ximena Lucía Raffo Iraolagoitia, Sol Yanel Núñez, Jessica Mariel Sierra, Andrea Ziblat, María Cecilia Santilli, Nicolás Gilio, Evangelina Almada, Constanza Lauche, Romina Pardo, Carolina Inés Domaica, Mercedes Beatriz Fuertes, Kevin Patrick Madauss, Israel S Gloger, Vanesa Zylberman, Fernando Alberto Goldbaum, Norberto Walter Zwirner
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 1 (2020)
Background Natural killer and cytotoxic CD8+ T cells are major players during antitumor immunity. They express NKG2D, an activating receptor that promotes tumor elimination through recognition of the MHC class I chain-related proteins A and B (MICA a
Externí odkaz:
https://doaj.org/article/60794d6d6f5348769085d3ffeeb174f9
Autor:
Daniel J. Murphy, Jennifer P. Morton, Owen J. Sansom, Seth B. Coffelt, Leo M. Carlin, Andrew V. Biankin, William Clark, Colin Nixon, Katarina Gyuraszova, Saadia A. Karim, Curtis Rink, Sarah Neidler, Robin Shaw, Rosanna Upstill-Goddard, Björn Kruspig, Sarah Laing, Ann Hedley, Declan Whyte, Robert Wiesheu, Ximena Raffo-Iraolagoitia, Tiziana Monteverde, Nathiya Muthalagu
MYC is implicated in the development and progression of pancreatic cancer, yet the precise level of MYC deregulation required to contribute to tumor development has been difficult to define. We used modestly elevated expression of human MYC, driven f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0cd13536b16418ef57a51deb42fe2576
https://doi.org/10.1158/2159-8290.c.6547897.v1
https://doi.org/10.1158/2159-8290.c.6547897.v1
Autor:
Daniel J. Murphy, Jennifer P. Morton, Owen J. Sansom, Seth B. Coffelt, Leo M. Carlin, Andrew V. Biankin, William Clark, Colin Nixon, Katarina Gyuraszova, Saadia A. Karim, Curtis Rink, Sarah Neidler, Robin Shaw, Rosanna Upstill-Goddard, Björn Kruspig, Sarah Laing, Ann Hedley, Declan Whyte, Robert Wiesheu, Ximena Raffo-Iraolagoitia, Tiziana Monteverde, Nathiya Muthalagu
6 supplementary Figures with legends under each; 3 Supplementary Tables; Supplementary Methods and References
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::040c578ef9926147b6216f683a201ac6
https://doi.org/10.1158/2159-8290.22535635.v1
https://doi.org/10.1158/2159-8290.22535635.v1
Autor:
Osvaldo L. Podhajcer, Andrea S. Llera, Norberto W. Zwirner, Vanesa Gottifredi, Elmer A. Fernández, Alicia I. Bravo, Edgardo Salvatierra, Ximena L. Raffo Iraolagoitia, Cecilia Rotondaro, Sabrina F. Mansilla, Raúl G. Spallanzani, Cristóbal Fresno, Lorena G. Benedetti, Leandro N. Güttlein
Understanding the mechanism of metastatic dissemination is crucial for the rational design of novel therapeutics. The secreted protein acidic and rich in cysteine (SPARC) is a matricellular glycoprotein which has been extensively associated with huma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ad989bffe36d56ee72976b813207ab0e
https://doi.org/10.1158/1541-7786.c.6540114.v1
https://doi.org/10.1158/1541-7786.c.6540114.v1
Autor:
Daniel J. Murphy, Jennifer P. Morton, Owen J. Sansom, Seth B. Coffelt, Leo M. Carlin, Andrew V. Biankin, William Clark, Colin Nixon, Katarina Gyuraszova, Saadia A. Karim, Curtis Rink, Sarah Neidler, Robin Shaw, Rosanna Upstill-Goddard, Björn Kruspig, Sarah Laing, Ann Hedley, Declan Whyte, Robert Wiesheu, Ximena Raffo-Iraolagoitia, Tiziana Monteverde, Nathiya Muthalagu
Spreadsheet of genes co-regulated by MYC & Miz1 in KMC PDAC cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85445eb0df2a3b684d67a96845226776
https://doi.org/10.1158/2159-8290.22535632.v1
https://doi.org/10.1158/2159-8290.22535632.v1
Autor:
Osvaldo L. Podhajcer, Andrea S. Llera, Norberto W. Zwirner, Vanesa Gottifredi, Elmer A. Fernández, Alicia I. Bravo, Edgardo Salvatierra, Ximena L. Raffo Iraolagoitia, Cecilia Rotondaro, Sabrina F. Mansilla, Raúl G. Spallanzani, Cristóbal Fresno, Lorena G. Benedetti, Leandro N. Güttlein
This file contains legends of Supplementary Figures S1-S8
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b9ad1d2cd2f80e53122f5a77a442beb
https://doi.org/10.1158/1541-7786.22512063.v1
https://doi.org/10.1158/1541-7786.22512063.v1