AAV-mediated expression of a new conformational anti-aggregated α-synuclein antibody prolongs survival in a genetic model of α-synucleinopathies

Autor: Matthias Düchs, Dragica Blazevic, Philipp Rechtsteiner, Cynthia Kenny, Thorsten Lamla, Sarah Low, Jimmy Savistchenko, Manuela Neumann, Ronald Melki, Tanja Schönberger, Birgit Stierstorfer, David Wyatt, Frederik Igney, Thomas Ciossek

Publikováno v: npj Parkinson's Disease, Vol 9, Iss 1, Pp 1-15 (2023)

Abstract Prion-like transmission of pathology in α-synucleinopathies like Parkinson’s disease or multiple system atrophy is increasingly recognized as one potential mechanism to address disease progression. Active and passive immunotherapies targe

Externí odkaz: https://doaj.org/article/bfa18d4f4cb54bf398d1a6ddf489f5be

Evaluating Antibody Pharmacokinetics as Prerequisite for Determining True Efficacy as Shown by Dual Targeting of PD-1 and CD96

Autor: Christina Boch, Markus Reschke, Frederik Igney, Peter Maier, Philipp Müller, Sarah Danklmaier, Krishna Das, Tamara Hofer, Guido Wollmann, Wolfgang Rist

Publikováno v: Biomedicines, Vol 10, Iss 9, p 2146 (2022)

One important prerequisite for developing a therapeutic monoclonal antibody is to evaluate its in vivo efficacy. We tested the therapeutic potential of an anti-CD96 antibody alone or in combination with an anti-PD-1 antibody in a mouse colon cancer m

Externí odkaz: https://doaj.org/article/4c7c79a08acf468b81bf619b1357f79f

Riboswitch-controlled IL-12 gene therapy reduces hepatocellular cancer in mice.

Autor: Düchs, Matthias J., Kratzer, Ramona F., Vieyra-Garcia, Pablo, Strobel, Benjamin, Schönberger, Tanja, Groß, Peter, Aljayyoussi, Ghaith, Gupta, Aradhana, Lang, Isabel, Klein, Holger, Morilla, Sandra Martinez, Hopf, Stefan, Park, John, Kreuz, Sebastian, Klugmann, Matthias, Igney, Frederik H.

Publikováno v: Frontiers in Immunology; 2024, p1-19, 19p

AAV-mediated expression of a new conformational anti-aggregated α-synuclein antibody prolongs survival in a genetic model of α-synucleinopathies

Autor: Düchs, Matthias, Blazevic, Dragica, Rechtsteiner, Philipp, Kenny, Cynthia, Lamla, Thorsten, Low, Sarah, Savistchenko, Jimmy, Neumann, Manuela, Melki, Ronald, Schönberger, Tanja, Stierstorfer, Birgit, Wyatt, David, Igney, Frederik, Ciossek, Thomas

Publikováno v: npj Parkinson's Disease 9(1), 91 (2023). doi:10.1038/s41531-023-00542-9
npj Parkinson's Disease
npj Parkinson's Disease, 2023, 9, pp.91. ⟨10.1038/s41531-023-00542-9⟩

International audience; Prion-like transmission of pathology in α-synucleinopathies like Parkinson’s disease or multiple system atrophy is increasingly recognized as one potential mechanism to address disease progression. Active and passive immuno

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::1175c9e05a5c149156327b1bbae5ed61
https://pub.dzne.de/record/258682

AAV-mediated Expression of a Novel Conformational Anti-Aggregated α-Synuclein Antibody Prolongs Survival in a Genetic Model of α-Synucleinopathies

Autor: Matthias Düchs, Dragica Blazevic, Philipp Rechtsteiner, Cynthia Kenny, Thorsten Lamla, Sarah Low, Jimmy Savistchenko, Manuela Neumann, Ronald Melki, Tanja Schönberger, Birgit Stierstorfer, David Wyatt, Frederik Igney, Thomas Ciossek

Prion-like transmission of pathology in α-synucleinopathies like Parkinson’s disease or multiple system atrophy is increasingly recognized as one potential mechanism to address disease progression. Active and passive immunotherapies targeting inso

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8926442dadbf8f2667aede74b3b6140c
https://doi.org/10.1101/2022.11.30.518485