Výsledky vyhledávání - "A. I. Undrovinas"

Late Sodium Current is a New Therapeutic Target to Improve Contractility and Rhythm in Failing Heart

Autor: Albertas I. Undrovinas, Victor A. Maltsev

Publikováno v: Cardiovascular & Hematological Agents in Medicinal Chemistry. 6:348-359

Most cardiac Na+ channels open transiently within milliseconds upon membrane depolarization and are responsible for the excitation propagation. However, some channels remain active during hundreds of milliseconds, carrying the so-called persistent or

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88457fa9245c539d59ea033fe2d3b341
https://doi.org/10.2174/187152508785909447

Zobrazit plný text záznamu

Modulation of late sodium current by Ca2+, calmodulin, and CaMKII in normal and failing dog cardiomyocytes: similarities and differences

Autor: Hani N. Sabbah, Vitaliy Reznikov, Victor A. Maltsev, Albertas I. Undrovinas, Nidas A. Undrovinas

Publikováno v: American Journal of Physiology-Heart and Circulatory Physiology. 294:H1597-H1608

Augmented and slowed late Na+ current ( INaL) is implicated in action potential duration variability, early afterdepolarizations, and abnormal Ca2+ handling in human and canine failing myocardium. Our objective was to study INaL modulation by cytosol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5889496c115374632f3ffdfdb69adcf
https://doi.org/10.1152/ajpheart.00484.2007

Zobrazit plný text záznamu

Late sodium current in failing heart: Friend or foe?

Autor: Albertas I. Undrovinas, Victor A. Maltsev

Publikováno v: Progress in Biophysics and Molecular Biology. 96:421-451

Most cardiac Na+ channels open transiently upon membrane depolarization and then are quickly inactivated. However, some channels remain active, carrying the so-called persistent or late Na+ current (INaL) throughout the action potential (AP) plateau.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a97909ff4bbc0dbf5267cecf89428975
https://doi.org/10.1016/j.pbiomolbio.2007.07.010

Zobrazit plný text záznamu

A multi-modal composition of the late Na+ current in human ventricular cardiomyocytes

Autor: Albertas I. Undrovinas, Victor A. Maltsev

Publikováno v: Cardiovascular Research. 69:116-127

We reported an ultraslow late Na+ current (INaL) in ventricular cardiomyocytes of human hearts. INaL has been implicated in regulation of action potential duration in normal hearts and repolarization abnormalities in failing hearts. We have also iden

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0558ea162b91c65da9182b256b22647e
https://doi.org/10.1016/j.cardiores.2005.08.015

Zobrazit plný text záznamu

Reversal of Chronic Molecular and Cellular Abnormalities Due to Heart Failure by Passive Mechanical Ventricular Containment

Autor: Pervaiz A. Chaudhry, Sharad Rastogi, Anastassia Todor, Takayuki Mishima, Hani N. Sabbah, Sudhish Mishra, Albertas I. Undrovinas, Elaine J. Tanhehco, George Suzuki, Victor G. Sharov, Ramesh C Gupta

Publikováno v: Circulation Research. 93:1095-1101

Passive mechanical containment of failing left ventricle (LV) with the Acorn Cardiac Support Device (CSD) was shown to prevent progressive LV dilation in dogs with heart failure (HF) and increase ejection fraction. To examine possible mechanisms for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::870cc099d33d3657d33204941aad1166
https://doi.org/10.1161/01.res.0000101932.70443.fe

Zobrazit plný text záznamu

Gating of the Late Na+ Channel in Normal and Failing Human Myocardium

Autor: Victor A. Maltsev, John W. Kyle, Norman H. Silverman, Albertas I. Undrovinas, Hani N. Sabbah

Publikováno v: Journal of Molecular and Cellular Cardiology. 34:1477-1489

A. I. Undrovinas, V. A. Maltsev, J., W. Kyle, N. S ilverman and H. N. Sabbah. Gating of the Late Na+ Channel in Normal and Failing Human Myocardium. Journal of Molecular and Cellular Cardiology (2002) 34, 1477–1489. We previously reported an ultras

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::083cc39e6e984cfec463e917a97f750e
https://doi.org/10.1006/jmcc.2002.2100

Zobrazit plný text záznamu

Down-regulation of sodium current in chronic heart failure: effect of long-term therapy with carvedilol

Autor: Victor A. Maltsev, Albertas I. Undrovinas, Hani N. Sabbah

Publikováno v: Cellular and Molecular Life Sciences (CMLS). 59:1561-1568

Evidence has accumulated recently about the importance of alterations in Na+ channel function and slow myocardial conduction for arrhythmias in the infarcted and failing heart. The present study tested a hypothesis that Na+ current (INa/C) density de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::064c09a636e8a2084366cfe566fd2730
https://doi.org/10.1007/s00018-002-8529-0

Zobrazit plný text záznamu

[Untitled]

Autor: Hani N. Sabbah, Walid Haddad, Albertas I. Undrovinas, Bella Felzen, Sidney Goldstein, Ricardo Aviv, Omar Nass, Nissim Darvish, Victor A. Maltsev, Yuval Mika, Shlomo Ben-Haim, Victor G. Sharov

Publikováno v: Heart Failure Reviews. 6:45-53

The intravenous use of positive inotropic agents, such as sympathomimetics and phosphodiesterase inhibitors, in heart failure is limited by pro-arrhythmic and positive chronotropic effects. Chronic use of these agents, while eliciting an improvement

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7fc97066e03ab911efdc9898adf4bd65
https://doi.org/10.1023/a:1009855208097

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání