Zobrazeno 1 - 10
of 17
pro vyhledávání: '"A. I. Rashchenko"'
Autor:
A. A. Spasov, O. N. Zhukovskaya, A. I. Rashchenko, A. A. Brigadirova, R. A. Litvinov, N. A. Gurova, A. V. Smirnov, N. G. Pan’shin, H. S.A. Abbas, A. S. Morkovnik
Publikováno v:
Фармация и фармакология (Пятигорск), Vol 10, Iss 6, Pp 549-561 (2023)
Advanced glycation end-products play an important role in the development of diabetic complications, so slowing down of glycated proteins’ cross-links formation have been suggested as a potential therapeutic option for the treatment of vascular dia
Externí odkaz:
https://doaj.org/article/d4d13d12ef394ea1a10e466236f08455
Autor:
A. A. Spasov, L. A. Smirnova, O. Yu. Grechko, N. V. Eliseeva, Yu. V. Lifanova, A. I. Rashchenko, O. N. Zhukovskaya, A. S. Morkovnik, V. A. Anisimova
Publikováno v:
Фармация и фармакология (Пятигорск), Vol 9, Iss 2, Pp 149-160 (2021)
The aim of the study is the investigation of the pharmacokinetic properties of the RU-1205 compound, with previously identified kappa-agonistic and analgesic effects, at a single oral administration, as well as comparison of the relationship between
Externí odkaz:
https://doaj.org/article/4c0fb6efffa84b93b12c9aa199034531
Autor:
Alexander A. Spasov, Lyudmila A. Smirnova, Olesya Iu. Grechko, Natalya V. Eliseeva, Yuliya V. Lifanova, Andrey I. Rashchenko, Olga N. Zhukowskaia, Anatoly S. Morkovnik, Vera A. Anisimova, Olga E. Syrvacheva
Publikováno v:
Research Results in Pharmacology, Vol 7, Iss 2, Pp 59-65 (2021)
Introduction: The purpose was to study the pharmacokinetic properties of RU-1205 with the previously identified kappa-agonistic and analgesic effects after parenteral administration. Materials and methods: Pharmacokinetic parameters of RU-1205 after
Externí odkaz:
https://doaj.org/article/48df2d837b5941d79dbe995f2a907a48
Autor:
Alexander A. Spasov, O. N. Zhukovskaya, O. Yu. Grechko, V. A. Anisimova, Anatolii S. Morkovnik, A. I. Rashchenko, Smirnova La, Natalya V. Eliseeva, Yu. V. Lifanova
Publikováno v:
Farmaciâ i Farmakologiâ (Pâtigorsk), Vol 9, Iss 2, Pp 149-160 (2021)
The aim of the study is the investigation of the pharmacokinetic properties of the RU-1205 compound, with previously identified kappa-agonistic and analgesic effects, at a single oral administration, as well as comparison of the relationship between
Autor:
Olesya Iu. Grechko, Olga N. Zhukowskaia, Olga E. Syrvacheva, Alexander A. Spasov, A. I. Rashchenko, V. A. Anisimova, Anatoly S. Morkovnik, Natalya V. Eliseeva, Yuliya V. Lifanova, Lyudmila A. Smirnova
Publikováno v:
Research Results in Pharmacology, Vol 7, Iss 2, Pp 59-65 (2021)
Research Results in Pharmacology 7(2): 59-65
Research Results in Pharmacology 7(2): 59-65
Introduction: The purpose was to study the pharmacokinetic properties of RU-1205 with the previously identified kappa-agonistic and analgesic effects after parenteral administration. Materials and methods: Pharmacokinetic parameters of RU-1205 after
Autor:
Alexander A. Spasov, A. F. Kucheryavenko, A. I. Rashchenko, A. K. Brel, S. S. Popov, O. A. Salaznikova, R. A. Litvinov, S. V. Lisina
Publikováno v:
Pharmaceutical Chemistry Journal. 53:511-515
A series of N1, N3-bis-hydroxybenzoyl, -acetoxybenzoyl, and -methoxybenzoyl uracil derivatives were synthesized. All compounds were screened for the ability to rupture protein cross links and antiglycating, chelating, and antiaggregant properties, wh
Autor:
A. V. Ivanov, A. F. Kucheryavenko, V. V. Batrakov, O. A. Salaznikova, D. D. Shamshina, R. A. Litvinov, S. V. Lisina, A. I. Rashchenko, A. K. Brel, Yu. N. Budaeva, Alexander A. Spasov
Publikováno v:
Russian Journal of Bioorganic Chemistry. 44:769-777
New uracil and thymine derivatives, N1-,N3- and N1,N3-(RO-benzoyl)-(1H,3H)-pyrimidine- 2,4-diones, were synthesized (RO- is hydroxy, acetoxy- or methoxy-group). The compounds were studied in a complex of in vitro tests for the ability to inhibit the
Autor:
Alexander A. Spasov, V. A. Kuznetsova, Denis A. Babkov, Natalya V. Eliseeva, K. A. Gaidukova, O. N. Zhukovskaya, Tat’yana A. Kuz’menko, A. I. Rashchenko, Anatolii S. Morkovnik, O. Yu. Grechko, A. F. Kucheryavenko, O. A. Salaznikova, V. A. Anisimova
Publikováno v:
Pharmaceutical Chemistry Journal. 52:385-391
A series of 2-(4-trifluoromethylphenyl)- and 2-trifluoromethyl-9-dialkylaminoalkylimidazo[1,2-a]benzimidazoles were synthesized for the first time by reacting 2-amino-1-dialkylaminoalkylbenzimidazoles and 2-bromo-1-[(4-trifluoromethyl)phenyl]ethanone
Autor:
Denis A. Babkov, O. N. Zhukovskaya, Anatolii S. Morkovnik, Alexander A. Spasov, V. A. Sysoeva, H. S. A. Abbas, V. A. Anisimova, O. Yu. Mayka, A. I. Rashchenko, A. A. Brigadirova, R. A. Litvinov
Publikováno v:
Russian Chemical Bulletin. 66:1905-1912
An efficient method for the synthesis of novel 9H-imidazo[1,2-a]benzimidazole derivatives containing a biphenyl substituent at position 2 was developed. These compounds, belonging to the privileged substructures, have been tested for a wide range of
Autor:
Pavel M. Vassiliev, Denis A. Babkov, V. S. Lobasenko, A. I. Rashchenko, A. A. Brigadirova, Alexander A. Spasov, A. N. Kochetkov, Yu. V. Popov, O. S. Efremova, A. I. Kovaleva, V. A. Kuznetsova, T. K. Korchagina
Publikováno v:
Russian Journal of Bioorganic Chemistry. 43:163-169
New esters of N-benzoyl-3-phenoxyphenylcarboxamide acid and N-benzoyl-N′-4-bromophenyl-3-phenoxybenzamidine were synthesized. Some of the synthesized compounds were shown to inhibit the activity of dipeptidyl peptidase-4 and nonenzymatic glycosylat