Zobrazeno 1 - 10
of 42
pro vyhledávání: '"A. I. Pozdeev"'
Autor:
E. Koncina, M. Nurmik, V. I. Pozdeev, C. Gilson, M. Tsenkova, R. Begaj, S. Stang, A. Gaigneaux, C. Weindorfer, F. Rodriguez, M. Schmoetten, E. Klein, J. Karta, V. S. Atanasova, K. Grzyb, P. Ullmann, R. Halder, M. Hengstschläger, J. Graas, V. Augendre, Y. E. Karapetyan, L. Kerger, N. Zuegel, A. Skupin, S. Haan, J. Meiser, H. Dolznig, E. Letellier
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Fibroblasts have a considerable functional and molecular heterogeneity and can play various roles in the tumor microenvironment. Here we identify a pro-tumorigenic IL1R1+, IL-1-high-signaling subtype of fibroblasts, using multiple colorectal
Externí odkaz:
https://doaj.org/article/82addcedbdd2496da008d9fb3de1053a
Autor:
Catherine Delbrouck, Nicole Kiweler, Oleg Chen, Vitaly I. Pozdeev, Lara Haase, Laura Neises, Anaïs Oudin, Aymeric Fouquier d’Hérouël, Ruolin Shen, Lisa Schlicker, Rashi Halder, Antoine Lesur, Anne Schuster, Nadja I. Lorenz, Christian Jaeger, Maureen Feucherolles, Gilles Frache, Martyna Szpakowska, Andy Chevigne, Michael W. Ronellenfitsch, Etienne Moussay, Marie Piraud, Alexander Skupin, Almut Schulze, Simone P. Niclou, Elisabeth Letellier, Johannes Meiser
Publikováno v:
Cell Reports, Vol 42, Iss 9, Pp 113034- (2023)
Summary: Metabolic rewiring is essential for cancer onset and progression. We previously showed that one-carbon metabolism-dependent formate production often exceeds the anabolic demand of cancer cells, resulting in formate overflow. Furthermore, we
Externí odkaz:
https://doaj.org/article/d667e6854d774c98bcdedc3d5a151980
Autor:
Nicole Kiweler, Catherine Delbrouck, Vitaly I. Pozdeev, Laura Neises, Leticia Soriano-Baguet, Kim Eiden, Feng Xian, Mohaned Benzarti, Lara Haase, Eric Koncina, Maryse Schmoetten, Christian Jaeger, Muhammad Zaeem Noman, Alexei Vazquez, Bassam Janji, Gunnar Dittmar, Dirk Brenner, Elisabeth Letellier, Johannes Meiser
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Chemotherapeutic antifolates, such as methotrexate (MTX), impair cancer cell proliferation by inhibiting nucleotide synthesis. Here, the authors show that MTX sustains an autarkic mitochondrial one-carbon metabolism leading to serine synthesis to pro
Externí odkaz:
https://doaj.org/article/1b8b8042e550427e9245dff67e377dae
Autor:
Philipp A. Lang, Sarah Q. Crome, Haifeng C. Xu, Karl S. Lang, Laurence Chapatte, Elissa K. Deenick, Melanie Grusdat, Aleksandra A. Pandyra, Vitaly I. Pozdeev, Ruifeng Wang, Tobias A. W. Holderried, Harvey Cantor, Andreas Diefenbach, Alisha R. Elford, David R. McIlwain, Mike Recher, Dieter Häussinger, Tak W. Mak, Pamela S. Ohashi
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 10 (2020)
Elucidating key factors that regulate immune-mediated pathology in vivo is critical for developing improved strategies to treat autoimmune disease and cancer. NK cells can exhibit regulatory functions against CD8+ T cells following viral infection. H
Externí odkaz:
https://doaj.org/article/c6d755c74d6340298648772ef2029098
Autor:
Vitaly I. Pozdeev, Elisabeth Lang, Boris Görg, Hans J. Bidmon, Prashant V. Shinde, Gerald Kircheis, Diran Herebian, Klaus Pfeffer, Florian Lang, Dieter Häussinger, Karl S. Lang, Philipp A. Lang
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Abstract The devastating consequences of hepatic failure include hepatic encephalopathy, a severe, life threatening impairment of neuronal function. Hepatic encephalopathy is caused by impaired hepatic clearance of NH4 +. Cellular NH4 + uptake is acc
Externí odkaz:
https://doaj.org/article/ca0324e4a21046279b31b2b97c7642c2
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Cancer cells utilize multiple mechanisms to evade and suppress anticancer immune responses creating a “cold” immunosuppressive tumor microenvironment. Oncolytic virotherapy is emerging as a promising approach to revert tumor immunosuppression and
Externí odkaz:
https://doaj.org/article/af6af5f5c2824bd4b6548390261ad199
Autor:
Sathish Kumar Maney, Haifeng C. Xu, Jun Huang, Aleksandra A. Pandyra, Christian Ehlting, Renan Aguilar-Valenzuela, Vitaly I. Pozdeev, David R. McIlwain, Albert Zimmermann, Johannes G. Bode, Hartmut Hengel, Carsten J. Kirschning, Ira R. Kim, John Hiscott, Dirk Brenner, Dieter Häussinger, Pamela S. Ohashi, Tak W. Mak, Karl S. Lang, Philipp A. Lang
Publikováno v:
Cellular Physiology and Biochemistry, Vol 39, Iss 4, Pp 1271-1280 (2016)
Background/Aims: Viral infections represent a global health problem with the need for new viral therapies and better understanding of the immune response during infection. The most immediate and potent anti-viral defense mechanism is the production o
Externí odkaz:
https://doaj.org/article/9f36549429e64de5a13191fdb15dd7e2
Autor:
Elisabeth Lang, Vitaly I. Pozdeev, Haifeng C. Xu, Prashant V. Shinde, Kristina Behnke, Junnat M. Hamdam, Erik Lehnert, Rüdiger E. Scharf, Florian Lang, Dieter Häussinger, Karl S. Lang, Philipp A. Lang
Publikováno v:
Cellular Physiology and Biochemistry, Vol 39, Iss 2, Pp 668-676 (2016)
Background/Aims: Similar to apoptosis of nucleated cells, red blood cells (RBC) can undergo suicidal cell death - called eryptosis. It is characterized by cell shrinkage and phosphatidylserine translocation. Eryptosis is triggered by an increase of i
Externí odkaz:
https://doaj.org/article/88662ac9916e42f79dd354b01e3f315d
Autor:
Elisabeth Lang, Vitaly I. Pozdeev, Sergios Gatidis, Syed M. Qadri, Dieter Häussinger, Ralf Kubitz, Diran Herebian, Ertan Mayatepek, Florian Lang, Karl S. Lang, Philipp A. Lang
Publikováno v:
Cellular Physiology and Biochemistry, Vol 38, Iss 4, Pp 1500-1509 (2016)
Background/Aims: In nucleated cells, bile acids may activate cation channels subsequently leading to entry of Ca2+. In erythrocytes, increase of cytosolic Ca2+ activity triggers eryptosis, the suicidal death of erythrocytes characterized by phosphati
Externí odkaz:
https://doaj.org/article/21cfc1dff59a4aa8b57a3f6c6dfd1941
Autor:
Catherine Delbrouck, Nicole Kiweler, Vitaly I. Pozdeev, Laura Neises, Anaïs Oudin, Anne Schuster, Aymeric Fouquier d’Hérouël, Ruolin Shen, Rashi Halder, Antoine Lesur, Christoph Ogris, Nadia I. Lorenz, Christian Jaeger, Michael W. Ronellenfitsch, Marie Piraud, Alexander Skupin, Simone P. Niclou, Elisabeth Letellier, Johannes Meiser
Metabolic rewiring is essential to enable cancer onset and progression. One important metabolic pathway that is often hijacked by cancer cells is the one-carbon cycle, in which the third carbon of serine is oxidized to formate. We have previously sho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ecb9b1c6f36440a0d52dd55e5d9e89de
https://doi.org/10.1101/2023.01.23.525172
https://doi.org/10.1101/2023.01.23.525172
