Zobrazeno 1 - 10
of 29
pro vyhledávání: '"A. I. Makarkov"'
Autor:
F. N. Paleev, N. P. Sanina, A. I. Makarkov, N. M. Mylov, E. I. Ostrovskiy, N. N. Khishova, O. V. Moskalets, N. R. Paleev
Publikováno v:
Alʹmanah Kliničeskoj Mediciny, Vol 0, Iss 35, Pp 12-21 (2016)
Background: Autoantibodies to myocardial antigenic epitopes and corresponding autoreactive T cell clones play an important role in myocardial damage and in pathogenesis of infectious immune myocarditis. T lymphocytes subpopulations/regulatory T cells
Externí odkaz:
https://doaj.org/article/8f0b458ecf604a57a88f9e9639165975
Autor:
N. P. Sanina, F. N. Paleev, A. I. Makarkov, N. M. Mylov, E. I. Ostrovskiy, N. N. Khishova, O. V. Moskalets, N. R. Paleev
Publikováno v:
Alʹmanah Kliničeskoj Mediciny, Vol 0, Iss 35, Pp 22-29 (2016)
Background: Type 17 T-helpers (Th17) were first identified more than 10 years ago. Though, there are only limited studies on the role of Th17- mediated mechanisms in the immune pathogenesis of acute myocarditis and dilative cardiomyopathy. Aim: To as
Externí odkaz:
https://doaj.org/article/f4a193952b1e4bb08adb494a21551dc9
Publikováno v:
Российский кардиологический журнал, Vol 0, Iss 1, Pp 32-40 (2016)
Aim. To study quantitative parameters, specifics of functional state of the main subpopulations of peripheral blood lymphocytes of the infective-immune myocarditis patients (IIM) and postmyocarditis cardiosclerosis (PMC), and specifics of cytokine pr
Externí odkaz:
https://doaj.org/article/2845cb60525b4c6f922491370c3dcb96
Autor:
Karen Hager, Nathalie Landry, Pierre-Yves Charbonneau, Matthew P. Cheng, Marc-André D'Aoust, Alexander I. Makarkov, Judith Atkins, Asif Mahmood, Carolyn Finkle, Stéphane Pillet, Manon Couture, Iohann Boulay, Patricia Schimke, Annie Séguin, Sylvie St-Martin, Brian J. Ward, Jiwanjeet Dhaliwall, Philipe Gobeil, Sonia Trépanier
Publikováno v:
Nature Medicine
Several severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines are being deployed, but the global need greatly exceeds the supply, and different formulations might be required for specific populations. Here we report Day 42 interim saf
Autor:
Karen J, Hager, Gonzalo, Pérez Marc, Philipe, Gobeil, Ricardo S, Diaz, Gretchen, Heizer, Conrado, Llapur, Alexander I, Makarkov, Eduardo, Vasconcellos, Stéphane, Pillet, Fernando, Riera, Pooja, Saxena, Priscila, Geller Wolff, Kapil, Bhutada, Garry, Wallace, Hessam, Aazami, Christine E, Jones, Fernando P, Polack, Luciana, Ferrara, Judith, Atkins, Iohann, Boulay, Jiwanjeet, Dhaliwall, Nathalie, Charland, Manon M J, Couture, Julia, Jiang-Wright, Nathalie, Landry, Sophie, Lapointe, Aurélien, Lorin, Asif, Mahmood, Lawrence H, Moulton, Emmy, Pahmer, Julie, Parent, Annie, Séguin, Luan, Tran, Thomas, Breuer, Maria-Angeles, Ceregido, Marguerite, Koutsoukos, François, Roman, Junya, Namba, Marc-André, D'Aoust, Sonia, Trepanier, Yosuke, Kimura, Brian J, Ward, Steven, Zeig
Publikováno v:
The New England journal of medicine. 386(22)
Backgroud: coronavirus-like particles (CoVLP) that are produced in plants and display the prefusion spike glycoprotein of the original strain of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are combined with an adjuvant (Adjuvant Syst
Autor:
Alexander I. Makarkov, Stéphane Pillet, Michael Libman, Nathalie Landry, Annie Séguin, Brian J. Ward, Jiwanjeet Dhaliwall, Sonia Trépanier, Timo Vesikari
Publikováno v:
The Lancet. 396:1491-1503
Summary Background Seasonal influenza remains a substantial public health threat despite the availability of egg-derived and other vaccines. Plant-based manufacturing might address some of the limitations of current vaccines. We describe two phase 3
Autor:
Asif Mahmood, Annie Séguin, Matthew P. Cheng, Iohann Boulay, Karen Hager, Nathalie Landry, Sylvie St-Martin, Stéphane Pillet, Carolyn Finkle, Alexander I. Makarkov, Manon Couture, Pierre-Yves Charbonneau, Philipe Gobeil, Brian J. Ward, Jiwanjeet Dhaliwall, Judith Atkins, Sonia Trépanier, Patricia Schimke, Marc-André D'Aoust
Longer AbstractBackgroundThe stabilized prefusion form of the SARS-CoV-2 spike protein is produced by transient expression in Nicotiana benthamiana. The trimeric spike glycoproteins are displayed at the surface of self-assembling Virus-Like-Particles
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f55faf7fd2b17904fddd4ad68830da74
https://doi.org/10.1101/2020.11.04.20226282
https://doi.org/10.1101/2020.11.04.20226282
Publikováno v:
Vaccine. 36:4485-4493
Background Serum hemagglutination inhibition (HAI) and microneutralization (MN) antibodies are often used as a correlate of protection for influenza. However, these manual assays are labor-intensive and difficult to standardize due to variability in
Autor:
Michał M. Bonar, Brianne J Lindsay, Nathalie Landry, Alexander I. Makarkov, Ian N Costas-Cancelas, Connie M. Krawczyk, Sabrina Chierzi, Brian J. Ward, Isabelle Rouiller, Kristin Hunt
Publikováno v:
Vaccine. 36:2147-2154
Plant-made virus-like particle (VLP) vaccines that display wild-type influenza hemagglutinin (HA) are rapidly advancing through clinical trials. Produced by transient transfection of Nicotiana benthamiana, these novel vaccines are unusually immunogen
Autor:
Paul W. Wiseman, Isabelle Rouiller, Nathalie Charland, Nathalie Landry, Angelica A. Gopal, Elizabeth Ruiz-Lancheros, Makan Golizeh, Momar Ndao, Stéphane Pillet, Alexander I. Makarkov, Sabrina Chierzi, Brian J. Ward, Ian N Costas-Cancelas
Publikováno v:
npj Vaccines, Vol 4, Iss 1, Pp 1-12 (2019)
NPJ Vaccines
NPJ Vaccines
A growing body of evidence supports the importance of T cell responses to protect against severe influenza, promote viral clearance, and ensure long-term immunity. Plant-derived virus-like particle (VLP) vaccines bearing influenza hemagglutinin (HA)