Zobrazeno 1 - 10
of 1 630
pro vyhledávání: '"A. Hubbuch"'
Autor:
Adrian Schimek, Judy K.M. Ng, Ioannes Basbas, Fabian Martin, Dongyue Xin, David Saleh, Jürgen Hubbuch
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 4, Pp 101335- (2024)
Externí odkaz:
https://doaj.org/article/e2415659fad24882ba916afd0500c2aa
Autor:
Angela Valentic, Jürgen Hubbuch
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 12 (2024)
Virus-like particles (VLPs) show considerable potential for a wide array of therapeutic applications, spanning from vaccines targeting infectious diseases to applications in cancer immunotherapy and drug delivery. In the context of hepatitis B core a
Externí odkaz:
https://doaj.org/article/ccd27f84971b41459ce449c0cedb96d8
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 12 (2024)
The conjugation reaction is the central step in the manufacturing process of antibody-drug conjugates (ADCs). This reaction generates a heterogeneous and complex mixture of differently conjugated sub-species depending on the chosen conjugation chemis
Externí odkaz:
https://doaj.org/article/0bf1f60593834f988cd1f6a6b7047471
Publikováno v:
In Journal of Chromatography A 11 October 2024 1734
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 12 (2024)
Virus-like particles (VLPs) are a promising class of biopharmaceuticals for vaccines and targeted delivery. Starting from clarified lysate, VLPs are typically captured by selective precipitation. While VLP precipitation is induced by step-wise or con
Externí odkaz:
https://doaj.org/article/781a4b0952a94375b029e37c6b58fcfd
Autor:
Christina Henriette Wegner, Sebastian Mathis Eming, Brigitte Walla, Daniel Bischoff, Dirk Weuster-Botz, Jürgen Hubbuch
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 12 (2024)
Protein crystallization as opposed to well-established chromatography processes has the benefits to reduce production costs while reaching a comparable high purity. However, monitoring crystallization processes remains a challenge as the produced cry
Externí odkaz:
https://doaj.org/article/fa4a1b828ff5499aa3726e5163379ec0
Autor:
Schimek, Adrian, Ng, Judy K.M., Basbas, Ioannes, Martin, Fabian, Xin, Dongyue, Saleh, David, Hubbuch, Jürgen
Publikováno v:
In Molecular Therapy - Methods & Clinical Development 13 June 2024 32(2)
Publikováno v:
Pharmaceuticals, Vol 17, Iss 9, p 1217 (2024)
Lipid nanoparticles (LNPs) and their versatile nucleic acid payloads bear great potential as delivery systems. Despite their complex lipid composition, their quality is primarily judged by particle characteristics and nucleic acid encapsulation. In t
Externí odkaz:
https://doaj.org/article/be3cc5bab4a144b7b68537a70d5f0cdc
Autor:
Hess, Rudger, Faessler, Jan, Yun, Doil, Mama, Ahmed, Saleh, David, Grosch, Jan-Hendrik, Wang, Gang, Schwab, Thomas, Hubbuch, Jürgen
Publikováno v:
In Journal of Chromatography A 15 March 2024 1718
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 12 (2024)
Chemometric modeling for spectral data is considered a key technology in biopharmaceutical processing to realize real-time process control and release testing. Machine learning (ML) models have been shown to increase the accuracy of various spectral
Externí odkaz:
https://doaj.org/article/1d6deebc14b142d98d4769d585f3ad23