Zobrazeno 1 - 10
of 1 345
pro vyhledávání: '"A. Houtkooper"'
Autor:
Julian Mevenkamp, Yvonne M. H. Bruls, Rodrigo Mancilla, Lotte Grevendonk, Joachim E. Wildberger, Kim Brouwers, Matthijs K. C. Hesselink, Patrick Schrauwen, Joris Hoeks, Riekelt H. Houtkooper, Mijke Buitinga, Robin A. de Graaf, Lucas Lindeboom, Vera B. Schrauwen-Hinderling
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract NADH and NAD+ act as electron donors and acceptors and NAD+ was shown to stimulate mitochondrial biogenesis and metabolic health. We here develop a non-invasive Phosphorous Magnetic Resonance Spectroscopy (31P-MRS) method to quantify these m
Externí odkaz:
https://doaj.org/article/641cc9cbaffb4da5a60ddf4d1b9cf383
Autor:
Signe Mosegaard, Krishna S. Twayana, Simone W. Denis, Jeffrey Kroon, Bauke V. Schomakers, Michel vanWeeghel, Riekelt H. Houtkooper, Rikke K. J. Olsen, Christian K. Holm
Publikováno v:
FASEB BioAdvances, Vol 6, Iss 9, Pp 337-350 (2024)
Abstract Stimulation of mammalian cells with inflammatory inducers such as lipopolysaccharide (LPS) leads to alterations in activity of central cellular metabolic pathways. Interestingly, these metabolic changes seem to be important for subsequent re
Externí odkaz:
https://doaj.org/article/7938490e07d84a48856606bf02802cfc
Autor:
Arwen W. Gao, Gaby El Alam, Yunyun Zhu, Weisha Li, Jonathan Sulc, Xiaoxu Li, Elena Katsyuba, Terytty Y. Li, Katherine A. Overmyer, Amelia Lalou, Laurent Mouchiroud, Maroun Bou Sleiman, Matteo Cornaglia, Jean-David Morel, Riekelt H. Houtkooper, Joshua J. Coon, Johan Auwerx
Publikováno v:
Cell Reports, Vol 43, Iss 10, Pp 114836- (2024)
Summary: Lifespan is influenced by complex interactions between genetic and environmental factors. Studying those factors in model organisms of a single genetic background limits their translational value for humans. Here, we mapped lifespan determin
Externí odkaz:
https://doaj.org/article/f30f2e821b914d2aa267921774dc8718
Autor:
Deena Damschroder, Rubén Zapata-Pérez, Kristin Richardson, Frédéric M. Vaz, Riekelt H. Houtkooper, Robert Wessells
Publikováno v:
Disease Models & Mechanisms, Vol 17, Iss 9 (2024)
Externí odkaz:
https://doaj.org/article/0bf961ac479d4f78b70d31fe154d154d
Autor:
Zhuqing Liang, Tyler Ralph-Epps, Michael W. Schmidtke, Pablo Lazcano, Simone W. Denis, Mária Balážová, Nevton Teixeira da Rosa, Mohamed Chakkour, Sanaa Hazime, Mindong Ren, Michael Schlame, Riekelt H. Houtkooper, Miriam L. Greenberg
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract Barth syndrome (BTHS) is a rare disorder caused by mutations in the TAFAZZIN gene. Previous studies from both patients and model systems have established metabolic dysregulation as a core component of BTHS pathology. In particular, features
Externí odkaz:
https://doaj.org/article/0764c46ec838464c99b44c7af0e10035
Autor:
He-Ling Wang, Jianying Zhang, Shu-qin Cao, Maria Jose Lagartos-Donate, Shi-qi Zhang, Sofie Lautrup, Zeping Hu, Costas A. Lyssiotis, Riekelt H. Houtkooper, Evandro F. Fang
Publikováno v:
STAR Protocols, Vol 5, Iss 4, Pp 103428- (2024)
Summary: Here, we present a NAD+/NADH detection assay for evaluating NAD+, NADH, and NAD+/NADH ratio across diverse biological models, including Caenorhabditis elegans, mouse muscle tissue, mouse whole blood, and human whole blood. We describe steps
Externí odkaz:
https://doaj.org/article/1cc870debf0a4ba188e1b13511719798
Autor:
Yorrick R.J. Jaspers, Sven W. Meyer, Mia L. Pras-Raves, Inge M.E. Dijkstra, Eric J.M. Wever, Adrie D. Dane, Jan-Bert van Klinken, Gajja S. Salomons, Riekelt H. Houtkooper, Marc Engelen, Stephan Kemp, Michel Van Weeghel, Frédéric M. Vaz
Publikováno v:
Journal of Lipid Research, Vol 65, Iss 6, Pp 100567- (2024)
Lipids play pivotal roles in an extensive range of metabolic and physiological processes. In recent years, the convergence of trapped ion mobility spectrometry and MS has enabled 4D-lipidomics, a highly promising technology for comprehensive lipid an
Externí odkaz:
https://doaj.org/article/deec6247e3684b2caada44c6c89b50f6
Autor:
Weisha Li, Rebecca L. McIntyre, Bauke V. Schomakers, Rashmi Kamble, Anne H.G. Luesink, Michel van Weeghel, Riekelt H. Houtkooper, Arwen W. Gao, Georges E. Janssens
Publikováno v:
iScience, Vol 27, Iss 6, Pp 109949- (2024)
Summary: As the global aging population rises, finding effective interventions to improve aging health is crucial. Drug repurposing, utilizing existing drugs for new purposes, presents a promising strategy for rapid implementation. We explored naltre
Externí odkaz:
https://doaj.org/article/71f17d80276646c883e60bcbc8f5ad53
Autor:
Gao, Arwen W., El Alam, Gaby, Zhu, Yunyun, Li, Weisha, Sulc, Jonathan, Li, Xiaoxu, Katsyuba, Elena, Li, Terytty Y., Overmyer, Katherine A., Lalou, Amelia, Mouchiroud, Laurent, Sleiman, Maroun Bou, Cornaglia, Matteo, Morel, Jean-David, Houtkooper, Riekelt H., Coon, Joshua J., Auwerx, Johan
Publikováno v:
In Cell Reports 22 October 2024 43(10)
Autor:
Balfoort, Berith M., Pampalone, Gioena, Ruiter, Jos P.N., Denis, Simone W., Brands, Marion M., Timmer, Corrie, Wagenmakers, Margreet A.E.M., Wanders, Ronald J.A., van Karnebeek, Clara D., Cellini, Barbara, Houtkooper, Riekelt H., Ferdinandusse, Sacha
Publikováno v:
In Molecular Genetics and Metabolism September-October 2024 143(1-2)