Výsledky vyhledávání - "A. Hergovich"

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The Strength of Absent Ties: Social Integration via Online Dating

Autor: Ortega, Josue, Hergovich, Philipp

We used to marry people to whom we were somehow connected. Since we were more connected to people similar to us, we were also likely to marry someone from our own race. However, online dating has changed this pattern; people who meet online tend to b

Externí odkaz: http://arxiv.org/abs/1709.10478

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Akademický článek

LATS1 but not LATS2 represses autophagy by a kinase-independent scaffold function

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)

The autophagic and Hippo pathways are both well characterized contributors to cancer. Here, Tang et al show that LATS1, but not LATS2, negatively regulates autophagy by promoting Beclin1 ubiquitination, which restricts lethal autophagy induced by sor

Externí odkaz: https://doaj.org/article/1bd4d7c4bf134f42b2b569c6511ab4d1

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Akademický článek

NDR2 kinase contributes to cell invasion and cytokinesis defects induced by the inactivation of RASSF1A tumor-suppressor gene in lung cancer cells

Autor: Maureen Keller, Fatéméh Dubois, Sylvain Teulier, Alexandre P. J. Martin, Jérôme Levallet, Elodie Maille, Solenn Brosseau, Nicolas Elie, Alexander Hergovich, Emmanuel Bergot, Jacques Camonis, Gérard Zalcman, Guénaëlle Levallet

Publikováno v: Journal of Experimental & Clinical Cancer Research, Vol 38, Iss 1, Pp 1-16 (2019)

Abstract Background RASSF1A, a tumor suppressor gene, is frequently inactivated in lung cancer leading to a YAP-dependent epithelial-mesenchymal transition (EMT). Such effects are partly due to the inactivation of the anti-migratory RhoB GTPase via t

Externí odkaz: https://doaj.org/article/c6c2ffc895a741f4a83085207c1ce502

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Cell-cell adhesion regulates Merlin/NF2 interaction with the PAF complex.

Autor: Anne E Roehrig, Kristina Klupsch, Juan A Oses-Prieto, Selim Chaib, Stephen Henderson, Warren Emmett, Lucy C Young, Silvia Surinova, Andreas Blees, Anett Pfeiffer, Maha Tijani, Fabian Brunk, Nicole Hartig, Marta Muñoz-Alegre, Alexander Hergovich, Barbara H Jennings, Alma L Burlingame, Pablo Rodriguez-Viciana

Publikováno v: PLoS ONE, Vol 16, Iss 8, p e0254697 (2021)

The PAF complex (PAFC) coordinates transcription elongation and mRNA processing and its CDC73/parafibromin subunit functions as a tumour suppressor. The NF2/Merlin tumour suppressor functions both at the cell cortex and nucleus and is a key mediator

Externí odkaz: https://doaj.org/article/060b7e02b03d49888281c2e401c2133d

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Stable MOB1 interaction with Hippo/MST is not essential for development and tissue growth control

Autor: Yavuz Kulaberoglu, Kui Lin, Maxine Holder, Zhongchao Gai, Marta Gomez, Belul Assefa Shifa, Merdiye Mavis, Lily Hoa, Ahmad A. D. Sharif, Celia Lujan, Ewan St. John Smith, Ivana Bjedov, Nicolas Tapon, Geng Wu, Alexander Hergovich

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)

The Hippo tumor suppressor pathway is essential for development and tissue growth control. Here the authors employ a multi-disciplinary approach to characterize the interactions of the three Hippo kinases with the signaling adaptor MOB1 and show how

Externí odkaz: https://doaj.org/article/057c5004ddb54609858a2e780a18b291

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Akademický článek

Structural definitions of Jumonji family demethylase selectivity

Autor: Pilka, Ewa S., James, Tim, Lisztwan, Joanna Hergovich

Publikováno v: In Drug Discovery Today June 2015 20(6):743-749

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