Modulation of stress-related behaviour by preproglucagon neurons and hypothalamic projections to the nucleus of the solitary tract

Autor: Marie K. Holt, Natalia Valderrama, Maria J. Polanco, Imogen Hayter, Ellena G. Badenoch, Stefan Trapp, Linda Rinaman

Publikováno v: Molecular Metabolism, Vol 91, Iss , Pp 102076- (2025)

Stress-induced behaviours are driven by complex neural circuits and some neuronal populations concurrently modulate diverse behavioural and physiological responses to stress. Glucagon-like peptide-1 (GLP-1)-producing preproglucagon (PPG) neurons with

Externí odkaz: https://doaj.org/article/8c386264c428488da1e1208b49a45885

RECOVER: sequential model optimization platform for combination drug repurposing identifies novel synergistic compounds in vitro

Autor: Bertin, Paul, Rector-Brooks, Jarrid, Sharma, Deepak, Gaudelet, Thomas, Anighoro, Andrew, Gross, Torsten, Martinez-Pena, Francisco, Tang, Eileen L., S, Suraj M, Regep, Cristian, Hayter, Jeremy, Korablyov, Maksym, Valiante, Nicholas, van der Sloot, Almer, Tyers, Mike, Roberts, Charles, Bronstein, Michael M., Lairson, Luke L., Taylor-King, Jake P., Bengio, Yoshua

For large libraries of small molecules, exhaustive combinatorial chemical screens become infeasible to perform when considering a range of disease models, assay conditions, and dose ranges. Deep learning models have achieved state of the art results

Externí odkaz: http://arxiv.org/abs/2202.04202

Tenecteplase versus standard of care for minor ischaemic stroke with proven occlusion (TEMPO-2): a randomised, open label, phase 3 superiority trial

Autor: Salluzzi, Marina, Blenkin, Nicole, Dueck, Ashley, Doram, Craig, Zhang, Qiao, Kenney, Carol, Ryckborst, Karla, Bohn, Shelly, Collier, Quentin, Taylor, Frances, Lethebe, B. Cord, Jambula, Anitha, Sage, Kayla, Toussaint, Lana, Save, Supryia, Lee, Jaclyn, Laham, N, Sultan, A.A., Deepak, A., Sitaram, A., Demchuk, Andrew M., Lockey, A., Micielli, A., Wadhwa, A., Arabambi, B., Graham, B., Bogiatzi, Chrysi, Doshi, Darshan, Chakraborty, D., Kim, Diana, Vasquez, D, Singh, D, Tse, Dominic, Harrison, E., Smith, E.E., Teleg, E., Klourfeld, E., Klein, G., Sebastian, I.A., Evans, J, Hegedus, J, Kromm, J, Lin, K, Ignacio, K, Ghavami, Kimia, Ismail, M., Moores, M., Panzini, M.A., Boyko, M., Almekhlafi, M.A., Newcommon, Nancy, Maraj, N., Imoukhuede, O., Volny, O., Stys, Peter, Couillard, Phillipe, Ojha, P., Eswaradass, P., Joundi, Raed, Singh, R., Asuncion, R.M., Muir, R.T., Dey, S., Mansoor, S., Wasyliw, S., Nagendra, S., Hu, Sherry, Althubait, S., Chen, S., Bal, S., Van Gaal, Stephen, Peters, Steven, Ray, Sucharita, Chaturvedi, S., Subramaniam, Suresh, Fu, Vivian, Villaluna, K., Maclean, G., King-Azote, P., Ma, C., Plecash, A., Murphy, C., Gorman, J., Wilson, L., Zhou, L., Benevente, O., Teal, P., Yip, S., Mann, S., Dewar, B., Demetroff, M., Shamloul, R., Beardshaw, R., Roberts, S., Blaquiere, D., Stotts, G., Shamy, M., Bereznyakova, O., Fahed, R., Alesefir, W., Lavoie, Suzy, Hache, A., Collard, K, Mackey, A., Gosselin-Lefebvre, S., Verreault, S., Beauchamp, B., Lambourn, L., Khaw, A., Mai, L., Sposato, L., Bres Bullrich, M., Azarpazhooh, R., Fridman, S., Kapoor, A., Southwell, A., Bardi, E., Fatakdawala, I., Kamra, M, Lopes, K., Popel, N., Norouzi, V., Liu, A., Liddy, A.M., Ghoari, B., Hawkes, C., Enriquez, C.A., Gladstone, D.J., Manosalva Alzate, H.A., Khosravani, H., Hopyan, J.J., Sivakumar, K., Son, M., Boulos, M.I., Hamind, M.A., Swartz, R.H., Murphy, R., Reiter, S., Fitzpatrick, T., Bhandari, V., Good, J., Penn, M., Naylor, M., Frost, S., Cayley, A., Akthar, F., Williams, J., Kalman, L., Crellin, L., Wiegner, R., Singh, R.S., Stewart, T., To, W., Singh, S., Pikula, A., Jaigobin, C., Carpani, F., Silver, F., Janssen, H., Schaafsma, J., del Campo, M., Alskaini, M., Rajendram, P., Fairall, P., Granfield, B., Crawford, D., Jabs, J., White, L., Sivakumar, L., Piquette, L., Nguyen, T., Nomani, A., Wagner, A., Alrohimi, A., Butt, A., D'Souza, A., Gajurel, B., Vekhande, C., Kamble, H., Kalashyan, H., Lloret, M., Benguzzi, M., Arsalan, N., Ishaque, N., Ashayeriahmadabad, R., Samiento, R., Hosseini, S., Kazi, S., Das, S., Sugumar, T., Selchen, D., Kostyrko, P., Muccilli, A., Saposnik, A.G., Vandervelde, C., Ratnayake, K., McMillan, S., Katsanos, A., Shoamanesh, A., Sahlas, D.J., Naidoo, V., Todorov, V., Toma, H., Brar, J., Lee, J., Horton, M., Shand, E., Weatherby, S., Jin, A., Durafourt, B., Jalini, S., Gardner, A., Tyson, C., Junk, E., Foster, K., Bolt, K., Sylvain, N., Maley, S., Urroz, L., Peeling, L., Kelly, M., Whelan, R., Cooley, R., Teitelbaum, J., Boutayeb, A., Moore, A., Cole, E., Waxman, L., Ben-Amor, N., Sanchez, R., Khalil, S., Nehme, A., Legault, C., Tampieri, D., Ehrensperger, E., Vieira, L., Cortes, M., Angle, M., Hannouche, M., Badawy, M., Werner, K., Wieszmuellner, S., Langer, A., Gisold, A., Zach, H., Rommer, P., Macher, S., Blechinger, S., Marik, W., Series, W., Baumgartinger, M., Krebs, S., Koski, J., Eirola, S., Ivanoff, T., Erakanto, A., Kupari, L., Sibolt, G., Panula, J., Tomppo, L., Tiainen, M., Ahlstrom, M., Martinez Majander, N., Suomalainen, O., Raty, S., Levi, C., Kerr, E., Allen, J., Kaauwai, L.P., Belevski, L., Russell, M., Ormond, S., Chew, A., Loiselle, A., Royan, A., Hughes, B., Garcia Esperon, C., Pepper, E., Miteff, F., He, J., Lycett, M., Min, M., Murray, N., Pavey, N., Starling de Barros, R., Gangadharan, S., Dunkerton, S., Waller, S., Canento Sanchez, T., Wellings, T., Edmonds, G., Whittaker, K.A., Ewing, M., Lee, P., Singkang, R., McDonald, A., Dos Santos, A., Shin, C., Jackson, D., Tsoleridis, J., Fisicchia, L., Parsons, N., Shenoy, N., Smith, S., Sharobeam, A., Balabanski, A., Park, A., Williams, C., Pavlin-Premri, D., Rodrigues, E., Alemseged, F., Ng, F., Zhao, H., Beharry, J., Ng, J.L., Williamson, J., Wong, J.Z.W., Li, K., Kwan, M.K., Valente, M., Yassi, N., Yogendrakumar, V., McNamara, B., Buchanan, C., McCarthy, C., Thomas, G., Stephens, K., Chung, M., Chung, M.F., Tang, M., Busch, T., Frost, T., Lee, R., Stuart, N., Pachani, N., Menon, A., Borojevic, B., Linton, C.M., Garcia, G., Callaly, E.P., Dewey, H., Liu, J., Chen, J., Wong, J., Nowak, K., To, K., Lizak, N.S., Bhalala, O., Park, P., Tan, P., Martins, R., Cody, R., Forbes, R., Chen, S.K., Ooi, S., Tu, S., Dang, Y.L., Ling, Z., Cranefield, J., Drew, R., Tan, A., Kurunawai, C., Harvey, J., Mahadevan, J.J., Cagi, L., Palanikumar, L., Chia, L.N., Goh, R., El-Masri, S., Urbi, B., Rapier, C., Berrill, H., McEvoy, H., Dunning, R., Kuriakose, S., Chad, T., Sapaen, V., Sabet, A., Shah, D., Yeow, D., Lilley, K., Ward, K., Mozhy Mahizhnan, M., Tan, M., Lynch, C., Coveney, S., Tobin, K., McCabe, J., Marnane, M., Murphy, S., Large, M., Moynihan, B., Boyle, K., Sanjuan, E., Sanchis, M., Boned, S., Pancorbo, O., Sala, V., Garcia, L., Garcia-Tornel, A., Juega, J., Pagola, J., Santana, K., Requena, M., Muchada, M., Olive, M., Lozano, P.J., Rubiera, M., Deck, M., Rodriguez, N., Gomez, B., Reyes Munoz, F.J., Gomez, A.S., Sanz, A.C., Garcia, E.C., Penacoba, G., Ramos, M.E., de Lera Alfonso, M., Feliu, A, Pardo, L., Ramirez, P., Murillo, A., Lopez Dominguez, D., Rodriguez, J., Terceno Izaga, M., Reina, M., Viturro, S.B., Bojaryn, U., Vera Monge, V.A., Silva Blas, Y., R Siew, R., Agustin, S J, Seet, C., Tianming, T., d'Emden, A., Murray, A., Welch, A., Hatherley, K., Day, N., Smith, W., MacRae, E., Mitchell, E.S., Mahmood, A., Elliot, J., Neilson, S., Biswas, V., Brown, C., Lewis, A., Ashton, A., Werring, D., Perry, R., Muhammad, R., Lee, Y.C., Black, A., Robinson, A., Williams, A., Banaras, A., Cahoy, C., Raingold, G., Marinescu, M., Atang, N., Bason, N., Francia, N., Obarey, S., Feerick, S., Joseph, J., Schulz, U., Irons, R., Benjamin, J., Quinn, L., Jhoots, M., Teal, R., Ford, G., Harston, G., Bains, H., Gbinigie, I., Mathieson, P., Sim, C.H., Hayter, E., Kennedy, K., Binnie, L., Priestley, N., Williams, R., Ghatala, R., Stratton, S., Blight, A., Zhang, L., Davies, A., Duffy, H., Roberts, J., Homer, J., Roberts, K., Dodd, K., Cawley, K., Martin, M., Leason, S., Cotgreave, S., Taylor, T., Nallasivan, A., Haider, S., Chakraborty, T., Webster, T., Gil, A., Martin, B., Joseph, B., Cabrera, C., Jose, D., Man, J., Aquino, J., Sebastian, S., Osterdahl, M., Kwan, M., Matthew, M., Ike, N., Bello, P., Wilding, P., Fuentes, R., Shah, R., Mashate, S., Patel, T., Nwanguma, U., Dave, V., Haber, A., Lee, A., O'Sullivan, A., Drumm, B., Dawson, A.C., Matar, T., Roberts, D., Taylor, E., Rounis, E., El-Masry, A., O'Hare, C., Kalladka, D., Jamil, S., Auger, S., Raha, O., Evans, M., Vonberg, F., Kalam, S., Ali Sheikh, A., Jenkins, I.H., George, J., Kwan, J., Blagojevic, J., Saeed, M., Haji-Coll, M., Tsuda, M., Sayed, M., Winterkron, N., Thanbirajah, N., Vittay, O., Karim, R., Smail, R.C., Gauhar, S., Elmamoun, S., Malani, S., Pralhad Kelavkar, S., Hiden, J., Ferdinand, P., Sanyal, R., Varquez, R., Smith, B., Okechukwu, C., Fox, E., Collins, E., Courtney, K., Tauro, S., Patterson, C., McShane, D., Roberts, G., McIImoyle, J., McGuire, K., Fearon, P., Gordon, P., Isaacs, K., Lucas, K., Smith, L., Dews, L., Bates, M., Lawrence, S., Heeley, S., Patel, V., Chin, Y.M., Sims, D., Littleton, E., Khaira, J., Nadar, K., Kieliszkowska, A., Sari, B., Domingos Belo, C., Smith, E., Manolo, E.Y., Aeron-Thomas, J., Doheny, M., Garcia Pardo, M., Recaman, M., Tibajia, M.C., Aissa, M., Mah, Y., Yu, T., Meenakshisundaram, S., Heller, S., Alsukhni, R., Williams, O., Farag, M., Benger, M., Engineer, A., Bayhonan, S., Conway, S., Bhalla, A., Nouvakis, D., Theochari, E., Boyle, F., Teo, J., King-Robson, J., Law, K.Y., Sztriha, L., McGovern, A., Day, D., Mitchell-Douglas, J., Francis, J., Iqbal, A., Punjabivaryani, P., Anonuevo Reyes, J., Anonuevo Reyes, M., Pauls, M., Buch, A., Hedstrom, A., Hutchinson, C., Kirkland, C., Newham, J., Wilkes, G., Fleming, L., Fleck, N., Franca, A., Chwal, B., Oldoni, C., Mantovani, G., Noll, G., Zanella, L., Soma, M., Secchi, T., Borelli, W., Rimoli, B.P., da Cunha Silva, G.H., Machado Galvao Mondin, L.A., Barbosa Cerantola, R., Imthon, A.K., Esaki, A.S., Camilo, M., Vincenzi, O.C., ds Cruz, R.R., Morillos, M.B., Riccioppa Rodrigues, G.G., Santos Ferreira, K., Pazini, A.M., Pena Pereira, M.A., de Albuquerque, A.L.A., Massote Fontanini, C.E., Matinez Rubio, C.F., dos Santos, D.T., Dias, F.A., Alves, F.F.A., Milani, C., Pegorer Santos, B., Winckler, F., De Souza, J.T., Bonome, L.A.M., Cury Silva, V.A., Teodoro, R.S., Modolo, G.P., Ferreira, N.C., Barbosa dos Santos, D.F., dos Santos Moreira, J.C., Cruz Guedes de Morais, A.B., Vieira, J., Mendes, G., de Queiroz, J.P., Coutts, Shelagh B ^*, Ankolekar, Sandeep, Appireddy, Ramana, Arenillas, Juan F, Assis, Zarina, Bailey, Peter, Barber, Philip A, Bazan, Rodrigo, Buck, Brian H, Butcher, Ken S, Camden, Marie-Christine, Campbell, Bruce C V, Casaubon, Leanne K, Catanese, Luciana, Chatterjee, Kausik, Choi, Philip M C, Clarke, Brian, Dowlatshahi, Dar, Ferrari, Julia, Field, Thalia S, Ganesh, Aravind, Ghia, Darshan, Goyal, Mayank, Greisenegger, Stefan, Halse, Omid, Horn, Mackenzie, Hunter, Gary, Imoukhuede, Oje, Kelly, Peter J, Kennedy, James, Kleinig, Timothy J, Krishnan, Kailash, Lima, Fabricio, Mandzia, Jennifer L, Marko, Martha, Martins, Sheila O, Medvedev, George, Menon, Bijoy K, Mishra, Sachin M, Molina, Carlos, Moussaddy, Aimen, Muir, Keith W, Parsons, Mark W, Penn, Andrew M W, Pille, Arthur, Pontes-Neto, Octávio M, Roffe, Christine, Serena, Joaquin, Simister, Robert, Singh, Nishita, Spratt, Neil, Strbian, Daniel, Tham, Carol H, Wiggam, M Ivan, Williams, David J, Willmot, Mark R, Wu, Teddy, Yu, Amy Y X, Zachariah, George, Zafar, Atif, Zerna, Charlotte, Hill, Michael D

Publikováno v: In The Lancet 15-21 June 2024 403(10444):2597-2605

A national multicentre study of outcomes and patient satisfaction with the virtual fracture clinic and the influence of the COVID-19 pandemic: The MAVCOV study

Autor: Brown, Jonathon, Lim, Jun Wei, Smith, Matthew, Lau, Nicole, Kamaraj, Achi, Zhou, Andrew, Lim, Jiang An, Jenkins, Lydia, Tennyson, Maria, Khan, Wasim, Foster, Amy, Rutherfoord, Catharine, Nathoo, Nikita, Domos, Peter, Padwick, Thomas, White, William, Robinson, Andrew, Vusirikala, Anuhya, Ensor, David, Akula, Maheswara, Vignaraja, Vikram, Rogers, Benedict, Kalabi, Fatemeh, Chan, Gareth, Clayton-Yeomans, Jacob, Gibbs, James, Titheradge, Rachel, Spalvieri, Stefano, Nair, Abhinav, Nathwani, Dinesh, Selvakumar, Jashan, Wihba, Kinan, Zakieh, Omar, Park, Andrew, Crewe, Claire, Ayeni, Funbi, Prowse, James, Kumar, Pradeep, Akinyemi, Tosin, Solim, Zahirah Nahaboo, Shaerf, Daniel, Sheikh, Hamza, Poustie, Mark, Rai, Sumnima, Birole, Umesh, Russell, Aimee, Loh, Cheryl, Drury, Colin, Cemm, Nicholas, Pravinkumar, Ruth, Baig, Saira, Bigsby, Ewan, Sellers, Grace, Dow, Joseph, Jenner, Lydia, Rogers, Michaela, Rankin, Sally, Mangtani, Anisha, Brameier, Devon, Rooker, Jemma, Anwer, Mohammed Azher, Kumar, Nakulan Nantha, Lam, Ryan, Andronic, Adrian, Phillips, Hannah, Attwood, Joe, Sturdee, Simon, Panagiotopoulos, Andreas, McVie, James, Boylan, Luke, Reid, Michael, Cheekoty, Prashasth, Edwards, Rebecca, Lindh, Amy, Kettle, Sarah, Genena, Ahmed, Hourston, George, Gopaul, Steven, Garg, Sunil, Gowers, Benjamin, Lennox-Warburton, Hannah, Sambhwani, Sharan, Shyamsundar, Srinivasan, Srinivasan, Suresh, Tavakkolizadeh, Adel, Petohazi, Alexandra, O'Hanlon, Ciaran, Everton, Harry Donkin, Pilkington, Isobel, Graziadei, Vivien, Anwar, Walid, Wignall, Alice, Jassal, Arun, Ilyas, Haris, Palan, Jeya, Monkhouse, Ray, Nijamudeen, Aysha, Caruana, Ethan, Gilbody, Julian, Malik, Maymunah, Saadat, Waqar, Yusuf, Karshe, Davies, Kimberley, Mueller, Marion, Tint, Pyi Han, Sengupta, Shreya, James, Andrew, Virji, Faizan, Bond, Gemma, Thumbadoo, Ruben, Teng, Wai Huang, Gee, Christopher, Warren, Craig, Nair, Gopikrishnan, Bohler, Iain, Periasamy, Kumar, Liao, Quintin, Ramasubbu, Rohan, Baston, Tessa, Witek, Alexander, Parwaiz, Hammad, Williams, James, Aboelmagd, Karim, Haines, Samuel, Bänziger, Carina, Harrold, Fraser, Abishek, Joshua, Davies, Peter, Pennington, Rachel, Parulekar, Ramaa, Sinnerton, Robert, Ravury, Sheetal, Macdonald, Angus, Emmerson, Benjamin, Inman, Dominic, Moedbeck, Edwina, Barber, Margaret, Jaiswal, Sharlene, Lewis, Rebecca, Downie, Samantha, Ng, Samantha, Shue, Wan Nee, Fosu, Augustine, Ko, Chai Chi, Lewis, Charlotte, Thiruchandran, Gajendiran, Jain, Siddharth, Ng, Zhаn, Wilson, Christopher, Toh, Ching, Miller, Gillian, Duncan, Katherine, McKee, Lesley, Mitchell, Martin, Ferguson, David, Hambidge, John, Wickramarachchi, Lilanthi, Abouelela, Amr, Hong, Anna, Oo, Aung Phyo, Kitsis, Christos, Elgalli, Mosab, Aros-Atolagbe, Robert, Clement, Adeline, Gibb, Catriona, Goffin, Joaquim, Jalal, Murtadhah, Leung, Billy, Neal-Smith, Gregory, Khatkar, Harman, Maher, Mark, Davies, Neville, Aboelmagd, Tariq, Jarrat, Jeremy, McKay, Joseph, Walmsley, Matthew, Greenhalgh, Michael, McCabe-Robinson, Olivia, Berry, Alexander, Iftinca, Dorin, Easwaran, Palakkad, Patel, Akash, Awow, Fatima, Pan, Myat, Patel, Nikhil, Khanal, Pragalva, Wagner, Boris, Athawes, Kirsten, Makaram, Navnit, Hegde, Rutwik, White, Tim, Williamson, Thomas, McAskill, Victoria, Stevens, Chloe, Malagelada, Francesc, Nasser, Mohammad Zeeshan, Ogunfuye, Omodolapo, Zahoor, Ubaid, Rogers, Gareth, Telford, Jeremy, Cowie, Jonathan, Hoggett, Lee, Havenhand, Tom, Do, Anh Duy, Cross, Charlotte, Morris, James, Hunter, Joel, Nabahin, Maram, Choudhary, Tashi, Campbell, Aaron, Mercer, Alexandra, Deyermond, Chloe, Fowler, Chris, McGoldrick, Peter, McCormac, Philip, Kakar, Sahil, McKenna, Sean, Boutros, Ihab ^an, Vial, Izziddine ^an, Bhullar, Samraj ^an, Lyle, Victoria ^an, Thomas, Alexander, Shean, Kate, Jacobs, Neal, Townsend, Oliver, Sharma, Akshara, van der Broeck, Alyssa, Hartley, Laura, O'Riordan, Marguerite, Gella, Sreenadh, Adlawan, Anjeli, Ijaz, Arhum, Al-kamali, Aws, Livesey, Jon, Yeshitila, Natania, Thayaparan, Anthony, Hayter, Edward, McLean, Elizabeth, Davies, Jessica, Walker, Joseph, Anakwe, Raymond, Fell, Adam, Haque, Aniqa, Sobti, Anshul, Jacob, Joshua, Moore, Thomas, Bhandari, Farzaan, Boitnott, Jasmine, Cheong, Jeremy, Lim, Wei Boon, Michla, Yusuf, Gilmore, Catherine, McConway, Jim, Elliott, Jonathan, Khan, Azizah, Madhu, Divine, Yusuf, Hannah, Gibby, Mary Louise, Thomas, Phillip, Abdel-Fattah, Areej, Martinson, Eliott, Akhtar, Muhammad Adeel, Hossain, Fahad, Ismayl, Ghiath, Khadabadi, Nikhil, Moores, Thomas, Goude, William, Ibrahim, Edward, Sivaganesh, Karthikeyan, Ogunjimi, Michael, Wilson, Michael, Shah, Sachi, McCluskey, Aled, Zakaria, Benjamin, Berber, Onur, Cuthbert, Rory, Mergia, Teresa, Khawaja, Abdullah, Hayman, Gregory, Relwani, Jai, Shaeir, Mohammed, Shah, Sohail, Peach, Christopher, Cook, Edward, Helston, Olivia, Koh, Yun Jee, Ng, Zhan H., Makaram, Navnit S., Kolhe, Shivam N., Mackenzie, Samuel P., Clement, Nick D., Duckworth, Andrew D., White, Tim O.

Publikováno v: In Injury March 2024 55(3)

Trajectory analysis of the work and life experience of healthcare workers during the COVID-19 pandemic: a longitudinal qualitative study

Autor: Pingting Zhu, Meiyan Qian, Amanda Lee, Mark Hayter, Wen Wang, Guanghui Shi, Qiwei Wu, Qiaoying Ji, Xinyue Gu, Hui Zhang, Yinwen Ding

Publikováno v: BMC Nursing, Vol 22, Iss 1, Pp 1-14 (2023)

Abstract Background The COVID-19 pandemic has posed a global health threat and has had a profoundly negative impact on the work and lives of healthcare workers. However, few people know how their experiences have evolved over time. Aims To describe h

Externí odkaz: https://doaj.org/article/7903a8fdd3fc438184f98aeb94554470