Induction of breast cancer resistance protein by the camptothecin derivative DX-8951f is associated with minor reduction of antitumour activity

Autor: I J Hoogsteen, Marc Maliepaard, Epie Boven, R.J. Scheper, Hennie M.M. Schlüper, A. H. Van Hattum, G Kohlhagen, George L. Scheffer, H.M. Pinedo, Y Pommier

Publikováno v: British Journal of Cancer

DX-8951f (exatecan mesylate), a new water-soluble derivative of camptothecin, is currently being evaluated in phase II clinical trials. Resistance may be acquired when treating cancer patients with DX-8951f. Therefore, we selected a subline of the hu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bba8bb70344f94c01c5eeb71130aeed
https://doi.org/10.1038/sj.bjc.6600508

New highly lipophilic camptothecin BNP1350 is an effective drug in experimental human cancer

Autor: Frederick H. Hausheer, Annemarie H. Van Hattum, Hennie M.M. Schlüper, Herbert M. Pinedo, Epie Boven

Publikováno v: International Journal of Cancer. 88:260-266

BNP1350, 7-[(2-trimethylsilyl)ethyl]-20(S)-camptothecin, is a novel semi-synthetic, highly lipophilic, silicon-containing camptothecin and an inhibitor of topoisomerase I. It has been supercomputer engineered for superior oral bioavailability, superi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d552b01eca0e36fb0ab479b6261f114f
https://doi.org/10.1002/1097-0215(20001015)88:2<260::aid-ijc18>3.0.co

Prognostic importance of paratracheal lymph node metastases

Autor: Dirk J. Kuik, Gordon B. Snow, Alexander H van Hattum, Robin E Plaat, C. René Leemans, Michiel W. M. van den Brekel, Remco de Bree

Publikováno v: Plaat, R E, De Bree, R, Kuik, D J, Van Den Brekel, M W M, Van Hattum, A H, Snow, G B & Leemans, C R 2005, ' Prognostic importance of paratracheal lymph node metastases ', Laryngoscope, vol. 115, no. 5, pp. 894-898 . https://doi.org/10.1097/01.MLG.0000160086.88523.C6
Laryngoscope, 115(5), 894-898. Wiley-Blackwell

Objectives: The aim of this retrospective study was to evaluate the prognostic significance of paratracheal lymph node (PTLN) metastases for tumor recurrence and survival for patients treated with total laryngectomy (TL) and PTLN dissection. Study De

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f5ce82579acab461ab58d6ddf121a64
https://research.vumc.nl/en/publications/1db65073-b976-4673-a4a4-af4915f5fa8b

New analogues of camptothecins. Activity and resistance

Autor: H.M. Pinedo, Epie Boven, Hennie M.M. Schlüper, Ilse Hoogsteen, Annemarie H. Van Hattum

Publikováno v: Annals of the New York Academy of Sciences. 922

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f09de0a266c68c0e4a0bfd077edb976
https://pubmed.ncbi.nlm.nih.gov/11193892

Further evaluation of quantitative nuclear image features for classification of lung carcinomas

Autor: D. M. van der Sluis, F.B.J.M. Thunnissen, Jan R.A. Baak, H. J. Houthoff, J. Tolboom, W. Schaafsma, A. H. Van Hattum, P. C. Diegenbach

Publikováno v: Pathology research and practice, 188(4-5), 531-535. ELSEVIER GMBH, URBAN & FISCHER VERLAG
Europe PubMed Central

The usefulness of quantitative nuclear image features (QNI) for the histological classification of lung carcinomas was investigated. As no clear distinction could be established between the distributions of these features for the nuclei of squamous c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9808d4d5d39abf47d1841210570014af
https://research.rug.nl/en/publications/13e19b14-407c-4c7e-9fbc-5d00f1bb5f15