The adaptive benefit of evolved increases in hemoglobin-O2 affinity is contingent on tissue O2 diffusing capacity in high-altitude deer mice

Autor: Oliver H. Wearing, Catherine M. Ivy, Natalia Gutiérrez-Pinto, Jonathan P. Velotta, Shane C. Campbell-Staton, Chandrasekhar Natarajan, Zachary A. Cheviron, Jay F. Storz, Graham R. Scott

Publikováno v: BMC Biology, Vol 19, Iss 1, Pp 1-15 (2021)

Abstract Background Complex organismal traits are often the result of multiple interacting genes and sub-organismal phenotypes, but how these interactions shape the evolutionary trajectories of adaptive traits is poorly understood. We examined how fu

Externí odkaz: https://doaj.org/article/fbe09799084040bdac218fcb486a398c

Evolved reductions in body temperature and the metabolic costs of thermoregulation in deer mice native to high altitude

Autor: Oliver H. Wearing, Graham R. Scott

Publikováno v: Proceedings of the Royal Society B: Biological Sciences. 289

The evolution of endothermy was instrumental to the diversification of birds and mammals, but the energetic demands of maintaining high body temperature could offset the advantages of endothermy in some environments. We hypothesized that reductions i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3f71a656dfc9eb8bd2ecc6cec12141a
https://doi.org/10.1098/rspb.2022.1553

Pulmonary hypertension is attenuated and ventilation-perfusion matching is maintained during chronic hypoxia in deer mice native to high altitude

Autor: Oliver H. Wearing, Graham R. Scott, Claire M. West, Rod G. Rhem

Publikováno v: American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 320:R800-R811

Hypoxia at high altitude can constrain metabolism and performance and can elicit physiological adjustments that are deleterious to health and fitness. Hypoxic pulmonary hypertension is a particularly serious and maladaptive response to chronic hypoxi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5cb2c73fe7bbb4adb7861c5c559b323
https://doi.org/10.1152/ajpregu.00282.2020

Genetic variation in haemoglobin is associated with evolved changes in breathing in high-altitude deer mice

Autor: Catherine M. Ivy, Oliver H. Wearing, Chandrasekhar Natarajan, Rena M. Schweizer, Natalia Gutiérrez-Pinto, Jonathan P. Velotta, Shane C. Campbell-Staton, Elin E. Petersen, Angela Fago, Zachary A. Cheviron, Jay F. Storz, Graham R. Scott

Publikováno v: J Exp Biol
Ivy, C M, Wearing, O H, Natarajan, C, Schweizer, R M, Gutiérrez-Pinto, N, Velotta, J P, Campbell-Staton, S C, Petersen, E E, Fago, A, Cheviron, Z A, Storz, J F & Scott, G R 2022, ' Genetic variation in haemoglobin is associated with evolved changes in breathing in high-altitude deer mice ', Journal of Experimental Biology, vol. 225, no. 2, jeb243595 . https://doi.org/10.1242/jeb.243595

Physiological systems often have emergent properties but the effects of genetic variation on physiology are often unknown, which presents a major challenge to understanding the mechanisms of phenotypic evolution. We investigated whether genetic varia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef7af77811ea1d7d03653bb70dd24972
https://doi.org/10.1242/jeb.243595

Infrared thermography as a technique to measure physiological stress in birds: Body region and image angle matter

Autor: Oliver H. Wearing, Gary Burness, Gabriela F. Mastromonaco, Glenn J. Tattersall, Joshua K. R. Tabh

Publikováno v: Physiological Reports, Vol 9, Iss 11, Pp n/a-n/a (2021)
Physiological Reports

In vertebrates, changes in surface temperature following exposure to an acute stressor are thought to be promising indicators of the physiological stress response that may be captured noninvasively by infrared thermography. However, the efficacy of u

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c9f677e9fb5817c9203220f056cb95d
https://doaj.org/article/0c46294f23f44b6d946cc50b4b8981a4