Synthesis and Evaluation of Optical and PET GLP-1 Peptide Analogues for GLP-1R Imaging

Autor: Babak Behnam Azad, Vanessa Rota, Lihai Yu, Rebecca Mcgirr, André H. St. Amant, Ting-Yim Lee, Savita Dhanvantari, Leonard G. Luyt PhD

Publikováno v: Molecular Imaging, Vol 14 (2015)

A fluorescein-GLP-1 (7-37) analog was generated to determine GLP-1R distribution in various cell types of the pancreas in both strains of mice and receptor-specific uptake was confirmed by blocking with exendin-4. Biodistribution studies were carried

Externí odkaz: https://doaj.org/article/5f3b5e72033541fca3b13a2fb36b1292

Norbornadienes: Robust and Scalable Building Blocks for Cascade 'Click' Coupling of High Molecular Weight Polymers

Autor: Javier Read de Alaniz, Emre H. Discekici, André H. St. Amant, Craig J. Hawker, Jung-Ah Song, Morgan W. Bates, Manuel Sanchez Zayas, Sophia J. Bailey, Athina Anastasaki, Shelby L. Shankel, Shay N. Nguyen

Publikováno v: Journal of the American Chemical Society, vol 141, iss 34
J Am Chem Soc

Herein, we report the development of a scalable and synthetically robust building block based on norbornadiene (NBD) that can be broadly incorporated into a variety of macromolecular architectures using traditional living polymerization techniques. B

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c233c21b5cf07f31336501a0148b6e39
https://escholarship.org/uc/item/9431529x

Tuning the Diels-Alder Reaction for Bioconjugation to Maleimide Drug-Linkers

Autor: Haihong Zhong, Stelios Florinas, André H. St. Amant, Herren Wu, Javier Read de Alaniz, Daniel Lemen, Christine Fazenbaker, R. James Christie, Shenlan Mao, Changshou Gao

Publikováno v: Bioconjugate chemistry. 29(7)

The thiol-maleimide linkage is widely used for antibody-drug conjugate (ADC) production; however, conjugation of maleimide-drugs could be improved by simplified procedures and reliable conjugate stability. Here, we report the evaluation of electron-r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a1e8c7fc091beea50d2bcc596444c14
https://pubmed.ncbi.nlm.nih.gov/29932647

Drosophila melanogaster as a function-based high-throughput screening model for anti-nephrolithiasis agents in kidney stone patients

Autor: Jun Yang, Tijani Osumah, Thomas Tailly, Nicholas Power, Hon S. Leong, Rachel Kim, Paul A. Spagnuolo, Dajung Kim, Hassan Razvi, André H. St. Amant, Aymon Naushad Ali, Jinqiang Hou, Dongxing Zhang, Sohrab Naushad Ali, Mohamed E. Ahmed, Tyler T. Cooper, Len G. Luyt, Thamara Dayarathna, Jeremy P. Burton

Publikováno v: Disease Models & Mechanisms, Vol 11, Iss 11 (2018)
DISEASE MODELS & MECHANISMS
Disease Models & Mechanisms

Kidney stone disease involves the aggregation of stone-forming salts consequent to solute supersaturation in urine. The development of novel therapeutic agents for this predominantly metabolic and biochemical disorder have been hampered by the lack o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78a9e685982f0c870e76d297e2f71a3a
https://doi.org/10.1242/dmm.035873

Direct synthesis of anilines and nitrosobenzenes from phenols

Autor: B. Newmeyer, Charles P. Frazier, Krista R Fruehauf, A. H. St. Amant, J. Read de Alaniz

Publikováno v: St Amant, AH; Frazier, CP; Newmeyer, B; Fruehauf, KR; & Read de Alaniz, J. (2016). Direct synthesis of anilines and nitrosobenzenes from phenols.. Organic & biomolecular chemistry, 14(24), 5520-5524. doi: 10.1039/c6ob00073h. UC Santa Barbara: Retrieved from: http://www.escholarship.org/uc/item/8gp1t0s5
Organic & biomolecular chemistry, vol 14, iss 24

A one-pot synthesis of anilines and nitrosobenzenes from phenols has been developed using an ipso-oxidative aromatic substitution ((i)SOAr) process. The products are obtained in good yields under mild and metal-free conditions. The leaving group effe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::202c0e34fc24a1fcde4b2bacd3c5b906
http://www.escholarship.org/uc/item/8gp1t0s5