Zobrazeno 1 - 10
of 56
pro vyhledávání: '"A. H. Lüdtke"'
Autor:
Marina Kaiser, Timo H. Lüdtke, Lena Deuper, Carsten Rudat, Vincent M. Christoffels, Andreas Kispert, Mark-Oliver Trowe
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Inner hair cells are essential for hearing but the molecular drivers of their differentiation have remained enigmatic. Here, the authors show that the transcription factor TBX2 has a key function in inducing and maintaining inner hair cell fate.
Externí odkaz:
https://doaj.org/article/a1ed0988f76a43e0ad9f7df5cbd56ffb
Autor:
Timo H. Lüdtke, Irina Wojahn, Marc-Jens Kleppa, Jasper Schierstaedt, Vincent M. Christoffels, Patrick Künzler, Andreas Kispert
Publikováno v:
Respiratory Research, Vol 22, Iss 1, Pp 1-17 (2021)
Abstract Background Tbx2 encodes a transcriptional repressor implicated in the development of numerous organs in mouse. During lung development TBX2 maintains the proliferation of mesenchymal progenitors, and hence, epithelial proliferation and branc
Externí odkaz:
https://doaj.org/article/da418b249c7b4155b293e1e7ce76a75f
Publikováno v:
Respiratory Research, Vol 20, Iss 1, Pp 1-14 (2019)
Abstract Background In the embryonic mammalian lung, mesenchymal cells act both as a signaling center for epithelial proliferation, differentiation and morphogenesis as well as a source for a multitude of differentiated cell types that support the st
Externí odkaz:
https://doaj.org/article/66de7a3310f448df8c3e7dcc4267408a
Autor:
Nathan Herdman, Friedhelm Hildebrandt, Dean Yimlamai, Andreas Kispert, Blake McCourt, Kari Nejak-Bowen, Yijen L. Wu, Markus Schüler, Eugen Widmeier, Anna-Carina Weiss, Merlin Airik, Donna B. Stolz, Timo H. Lüdtke, Rannar Airik
Publikováno v:
Hum Mol Genet
ANKS6 is a ciliary protein that localizes to the proximal compartment of the primary cilium, where it regulates signaling. Mutations in the ANKS6 gene cause multiorgan ciliopathies in humans, which include laterality defects of the visceral organs, r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::048dbb3fd152a2a8c9fd085b66965870
https://doi.org/10.1093/hmg/ddaa197
https://doi.org/10.1093/hmg/ddaa197
Publikováno v:
Respiratory Research, Vol 20, Iss 1, Pp 1-14 (2019)
Respiratory Research
Respiratory research, 20(1):292. BioMed Central
Respiratory Research
Respiratory research, 20(1):292. BioMed Central
BackgroundIn the embryonic mammalian lung, mesenchymal cells act both as a signaling center for epithelial proliferation, differentiation and morphogenesis as well as a source for a multitude of differentiated cell types that support the structure of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a4352a74c775177471ed48077f27e56
https://doaj.org/article/66de7a3310f448df8c3e7dcc4267408a
https://doaj.org/article/66de7a3310f448df8c3e7dcc4267408a
Autor:
Marc-Jens Kleppa, Patrick Künzler, Timo H. Lüdtke, Irina Wojahn, Jasper Schierstaedt, Andreas Kispert, Vincent M. Christoffels
Publikováno v:
Respiratory research, 22(1):85. BioMed Central
Respiratory Research
Respiratory Research, Vol 22, Iss 1, Pp 1-17 (2021)
Respiratory Research
Respiratory Research, Vol 22, Iss 1, Pp 1-17 (2021)
Background Tbx2 encodes a transcriptional repressor implicated in the development of numerous organs in mouse. During lung development TBX2 maintains the proliferation of mesenchymal progenitors, and hence, epithelial proliferation and branching morp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::416a2315b02c8aca130bbee45feae33d
https://pure.amc.nl/en/publications/combined-genomic-and-proteomic-approaches-reveal-dna-binding-sites-and-interaction-partners-of-tbx2-in-the-developing-lung(cc292f54-bd9f-43fa-8e8c-0c6e9c8a0b3d).html
https://pure.amc.nl/en/publications/combined-genomic-and-proteomic-approaches-reveal-dna-binding-sites-and-interaction-partners-of-tbx2-in-the-developing-lung(cc292f54-bd9f-43fa-8e8c-0c6e9c8a0b3d).html
Autor:
Jennifer Kurz, Anna-Carina Weiss, Hauke Thiesler, Fairouz Qasrawi, Lena Deuper, Jaskiran Kaur, Carsten Rudat, Timo H. Lüdtke, Irina Wojahn, Herbert Hildebrandt, Mark-Oliver Trowe, Andreas Kispert
Publikováno v:
Development (Cambridge, England). 149(4)
The contractile phenotype of smooth muscle cells (SMCs) is transcriptionally controlled by a complex of the DNA-binding protein SRF and the transcriptional co-activator MYOCD. The pathways that activate expression of Myocd and of SMC structural genes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c3b1f29b816fad34da3a013120fde21
https://pubmed.ncbi.nlm.nih.gov/35103284
https://pubmed.ncbi.nlm.nih.gov/35103284
Autor:
Mark-Oliver Trowe, Anna-Carina Weiss, Tobias Bohnenpoll, Timo H. Lüdtke, Maurice Labuhn, Andreas Kispert
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Scientific Reports
Scientific Reports
The differentiated cell types of the mature ureter arise from the distal ureteric bud epithelium and its surrounding mesenchyme. Uncommitted epithelial cells first become intermediate cells from which both basal and superficial cells develop. Mesench
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7629ef1e83c92f89f8a8b7d729e5ce1b
http://link.springer.com/article/10.1038/s41598-017-14790-2
http://link.springer.com/article/10.1038/s41598-017-14790-2
Autor:
Andreas Kispert, Franziska Greulich, Nurullah Aydoğdu, Mark-Oliver Trowe, Marc-Jens Kleppa, Tamrat M. Mamo, Regine Häfner, Irina Wojahn, Carsten Rudat, Tobias Bohnenpoll, Jennifer Kurz, Timo H. Lüdtke, Makoto Mark Taketo
Publikováno v:
American journal of physiology. Lung cellular and molecular physiology. 316(5)
The mesothelial lining of the lung, the visceral pleura, and of the heart, the epicardium, derive from a common multipotent precursor tissue, the mesothelium of the embryonic thoracic cavity that also contributes to organ-specific mesenchymal cell ty
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::976743458145183231e1d59e54bf13f3
https://pubmed.ncbi.nlm.nih.gov/30838864
https://pubmed.ncbi.nlm.nih.gov/30838864
Autor:
Jennifer Kurz, Patrick Blank, Timo H. Lüdtke, Lena Deuper, Thomas von Hahn, Andreas Kispert, Marc-Jens Kleppa, Marina Kaiser, Anna-Carina Weiss, Tamrat M. Mamo, Tobias Bohnenpoll, Mark-Oliver Trowe, Rui Costa, Rannar Airik
Publikováno v:
The Journal of pathology. 248(4)
The establishment of the peristaltic machinery of the ureter is precisely controlled to cope with the onset of urine production in the fetal kidney. Retinoic acid (RA) has been identified as a signal that maintains the mesenchymal progenitors of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01be0211606371a31a16050db8ff7d20
https://pubmed.ncbi.nlm.nih.gov/30916783
https://pubmed.ncbi.nlm.nih.gov/30916783