Universal DNA methylation age across mammalian tissues

Autor: A.T. Lu, Z. Fei, A. Haghani, T.R. Robeck, J.A. Zoller, C.Z. Li, R. Lowe, Q. Yan, J. Zhang, H. Vu, J. Ablaeva, V.A. Acosta-Rodriguez, D.M. Adams, J. Almunia, A. Aloysius, R. Ardehali, A. Arneson, C.S. Baker, G. Banks, K. Belov, N.C. Bennett, P. Black, D.T. Blumstein, E.K. Bors, C.E. Breeze, R.T. Brooke, J.L. Brown, G. Carter, A. Caulton, J.M. Cavin, L. Chakrabarti, I. Chatzistamou, H. Chen, K. Cheng, P. Chiavellini, O.W. Choi, S. Clarke, L.N. Cooper, M.L. Cossette, J. Day, J. DeYoung, S. DiRocco, C. Dold, E.E. Ehmke, C.K. Emmons, S. Emmrich, E. Erbay, C. Erlacher-Reid, C.G. Faulkes, S.H. Ferguson, C.J. Finno, J.E. Flower, J.M. Gaillard, E. Garde, L. Gerber, V.N. Gladyshev, V. Gorbunova, R.G. Goya, M.J. Grant, C.B. Green, E.N. Hales, M.B. Hanson, D.W. Hart, M. Haulena, K. Herrick, A.N. Hogan, C.J. Hogg, T.A. Hore, T. Huang, J.C. Izpisua Belmonte, A.J. Jasinska, G. Jones, E. Jourdain, O. Kashpur, H. Katcher, E. Katsumata, V. Kaza, H. Kiaris, M.S. Kobor, P. Kordowitzki, W.R. Koski, M. Kruetzen, S.B. Kwon, B. Larison, S.G. Lee, M. Lehmann, J.F. Lemaitre, A.J. Levine, C. Li, X. Li, A.R. Lim, D.T.S. Lin, D.M. Lindemann, T.J. Little, N. Macoretta, D. Maddox, C.O. Matkin, J.A. Mattison, M. McClure, J. Mergl, J.J. Meudt, G.A. Montano, K. Mozhui, J. Munshi-South, A. Naderi, M. Nagy, P. Narayan, P.W. Nathanielsz, N.B. Nguyen, C. Niehrs, J.K. O’Brien, P. O’Tierney Ginn, D.T. Odom, A.G. Ophir, S. Osborn, E.A. Ostrander, K.M. Parsons, K.C. Paul, M. Pellegrini, K.J. Peters, A.B. Pedersen, J.L. Petersen, D.W. Pietersen, G.M. Pinho, J. Plassais, J.R. Poganik, N.A. Prado, P. Reddy, B. Rey, B.R. Ritz, J. Robbins, M. Rodriguez, J. Russell, E. Rydkina, L.L. Sailer, A.B. Salmon, A. Sanghavi, K.M. Schachtschneider, D. Schmitt, T. Schmitt, L. Schomacher, L.B. Schook, K.E. Sears, A.W. Seifert, A. Seluanov, A.B.A. Shafer, D. Shanmuganayagam, A.V. Shindyapina, M. Simmons, K. Singh, I. Sinha, J. Slone, R.G. Snell, E. Soltanmaohammadi, M.L. Spangler, M.C. Spriggs, L. Staggs, N. Stedman, K.J. Steinman, D.T. Stewart, V.J. Sugrue, B. Szladovits, J.S. Takahashi, M. Takasugi, E.C. Teeling, M.J. Thompson, B. Van Bonn, S.C. Vernes, D. Villar, H.V. Vinters, M.C. Wallingford, N. Wang, R.K. Wayne, G.S. Wilkinson, C.K. Williams, R.W. Williams, X.W. Yang, M. Yao, B.G. Young, B. Zhang, Z. Zhang, P. Zhao, Y. Zhao, W. Zhou, J. Zimmermann, J. Ernst, K. Raj, S. Horvath

Aging is often perceived as a degenerative process resulting from random accrual of cellular damage over time. Despite this, age can be accurately estimated by epigenetic clocks based on DNA methylation profiles from almost any tissue of the body. Si

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b3b2b0572d2145944f8a6d2a5e261924
https://doi.org/10.1101/2021.01.18.426733

Photoredox activation of carbon dioxide for amino acid synthesis in continuous flow

Autor: Timothy F. Jamison, Matthew H. Katcher, Hyowon Seo

Publikováno v: Nature chemistry

Although carbon dioxide (CO2) is highly abundant, its low reactivity has limited its use in chemical synthesis. In particular, methods for carbon-carbon bond formation generally rely on two-electron mechanisms for CO2 activation and require highly ac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a80efcdc630a40501b4e0a6cb2f4fabf
https://doi.org/10.1038/nchem.2690

The discovery of reverse tricyclic pyridone JAK2 inhibitors. Part 2: Lead optimization

Autor: Lin Xu, Grace Chan, Melaney Bouthillette, Craig Rosenstein, Sathyajith E. Kumarasinghe, C. Gary Marshall, Tony Siu, Anjili Mathur, Alan B. Northrup, Michael D. Altman, Christopher J. Dinsmore, Matthew H. Katcher, Catherine White, Eric Bachman, Jonathan R. Young

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 24:1466-1471

This communication discusses the discovery of novel reverse tricyclic pyridones as inhibitors of Janus kinase 2 (JAK2). By using a kinase cross screening approach coupled with molecular modeling, a unique inhibitor–water interaction was discovered

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::019b05288f9a265bdc23c81724b809ed
https://doi.org/10.1016/j.bmcl.2014.02.011

Discovery of 1-[3-(1-Methyl-1H-pyrazol-4-yl)-5-oxo-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-7-yl]-N-(pyridin-2-ylmethyl)methanesulfonamide (MK-8033): A Specific c-Met/Ron Dual Kinase Inhibitor with Preferential Affinity for the Activated State of c-Met

Autor: Michael D. Altman, Christopher J. Dinsmore, John F. Reilly, Jonathan R. Young, Chaomin Li, Sangita B. Patel, Deborah Walker, Craig Rosenstein, David Joseph Guerin, Timothy Allison, Harold Hatch, Stephen M. Soisson, Sujal V. Deshmukh, Bart Lutterbach, Bo Sheng Pan, Danielle Falcone, Michael H. Reutershan, Keith W. Rickert, Matthew H. Katcher, Wei Lu, Melissa Chenard, Kevin J. Wilson, Alan B. Northrup, Alexander A. Szewczak, Matthew H. Daniels

Publikováno v: Journal of Medicinal Chemistry. 56:2294-2310

This report documents the first example of a specific inhibitor of protein kinases with preferential binding to the activated kinase conformation: 5H-benzo[4,5]cyclohepta[1,2-b]pyridin-5-one 11r (MK-8033), a dual c-Met/Ron inhibitor under investigati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1117137a3ef810ac7f93b40f98ec667e
https://doi.org/10.1021/jm301619u

Factors Associated with Non-Accidental Trauma Evaluation Among Patients <36 Months Old Presenting with Femur Fractures

Autor: Arielle H. Katcher, Matthew E. Oetgen, Allison Matthews

Publikováno v: Pediatrics. 140:112-112

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8d4dd5a2722d91146cb76e9c2de5ed4b
https://doi.org/10.1542/peds.140.1ma.112