Zobrazeno 1 - 10
of 142
pro vyhledávání: '"A. H. Jonkers"'
Autor:
Olivier B. Bakker, Annique Claringbould, Harm-Jan Westra, Henry Wiersma, Floranne Boulogne, Urmo Võsa, Carlos G. Urzúa-Traslaviña, Sophie Mulcahy Symmons, Mahmoud M. M. Zidan, Marie C. Sadler, Zoltán Kutalik, Iris H. Jonkers, Lude Franke, Patrick Deelen
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Genetic variants identified through genome-wide association studies (GWAS) are typically non-coding, exerting small regulatory effects on downstream genes. However, which downstream genes are ultimately impacted and how they confer risk rema
Externí odkaz:
https://doaj.org/article/9ce5ca1daf92482e81d7d7d7db513a2a
Autor:
Renée Moerkens, Joram Mooiweer, Aarón D. Ramírez-Sánchez, Roy Oelen, Lude Franke, Cisca Wijmenga, Robert J. Barrett, Iris H. Jonkers, Sebo Withoff
Publikováno v:
Cell Reports, Vol 43, Iss 7, Pp 114247- (2024)
Summary: Human induced pluripotent stem cell (hiPSC)-derived intestinal organoids are valuable tools for researching developmental biology and personalized therapies, but their closed topology and relative immature state limit applications. Here, we
Externí odkaz:
https://doaj.org/article/cd45fee274a64df99505faa880e9eee4
Autor:
Xiaojing Chu, Martin Jaeger, Joep Beumer, Olivier B. Bakker, Raul Aguirre-Gamboa, Marije Oosting, Sanne P. Smeekens, Simone Moorlag, Vera P. Mourits, Valerie A. C. M. Koeken, Charlotte de Bree, Trees Jansen, Ian T. Mathews, Khoi Dao, Mahan Najhawan, Jeramie D. Watrous, Irma Joosten, Sonia Sharma, Hans J. P. M. Koenen, Sebo Withoff, Iris H. Jonkers, Romana T. Netea-Maier, Ramnik J. Xavier, Lude Franke, Cheng-Jian Xu, Leo A. B. Joosten, Serena Sanna, Mohit Jain, Vinod Kumar, Hans Clevers, Cisca Wijmenga, Mihai G. Netea, Yang Li
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-22 (2021)
Abstract Background Recent studies highlight the role of metabolites in immune diseases, but it remains unknown how much of this effect is driven by genetic and non-genetic host factors. Result We systematically investigate circulating metabolites in
Externí odkaz:
https://doaj.org/article/c356b25dd4854dcbb5ff8d2fda446129
Autor:
Olivier B. Bakker, Aarón D. Ramírez-Sánchez, Zuzanna A. Borek, Niek de Klein, Yang Li, Rutger Modderman, Yvonne Kooy-Winkelaar, Marie K. Johannesen, Filomena Matarese, Joost H. A. Martens, Vinod Kumar, Jeroen van Bergen, Shuo-Wang Qiao, Knut E. A. Lundin, Ludvig M. Sollid, Frits Koning, Cisca Wijmenga, Sebo Withoff, Iris H. Jonkers
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Celiac disease is an auto-immune disease in which an immune response to dietary gluten leads to inflammation and subsequent atrophy of small intestinal villi, causing severe bowel discomfort and malabsorption of nutrients. The major instigat
Externí odkaz:
https://doaj.org/article/66b9019aaac7432d846ad8c14c396c51
Autor:
Aarón D. Ramírez-Sánchez, Xiaojing Chu, Rutger Modderman, Yvonne Kooy-Winkelaar, Sibylle Koletzko, Ilma R. Korponay-Szabó, Riccardo Troncone, Cisca Wijmenga, Luisa Mearin, Sebo Withoff, Iris H. Jonkers, Yang Li
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Celiac Disease (CeD) is a complex immune disorder involving villous atrophy in the small intestine that is triggered by gluten intake. Current CeD diagnosis is based on late-stage pathophysiological parameters such as detection of specific antibodies
Externí odkaz:
https://doaj.org/article/c002e07d244a472f8a2429709aee9339
Publikováno v:
Open Biology, Vol 10, Iss 1 (2020)
Over the past 15 years, genome-wide association studies (GWASs) have enabled the systematic identification of genetic loci associated with traits and diseases. However, due to resolution issues and methodological limitations, the true causal varia
Externí odkaz:
https://doaj.org/article/400b95126bb64dcc80450de6da029e61
Autor:
Victoria E.J.M. Palasantzas, Isabel Tamargo-Rubio, Kieu Le, Jelle Slager, Cisca Wijmenga, Iris H. Jonkers, Vinod Kumar, Jingyuan Fu, Sebo Withoff
Publikováno v:
Trends in Genetics, 39, 268-284
Trends in Genetics, 39, 4, pp. 268-284
Trends in Genetics, 39, 4, pp. 268-284
Item does not contain fulltext Genome-wide association studies (GWAS) have now correlated hundreds of genetic variants with complex genetic diseases and drug efficacy. Functional characterization of these factors remains challenging, particularly bec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69cc5a6251c32e6d5cf70c4d32709df8
https://doi.org/10.1016/j.tig.2023.01.002
https://doi.org/10.1016/j.tig.2023.01.002
Autor:
Bana Jabri, Dustin Shaw, Raúl Aguirre-Gamboa, Marcos Vieria, Saideep Gona, Nicholas DiNardi, Anni Wang, Anne Dumaine, Jody Gederloos, Zachary Earley, Katherine Meckel, Cezary Ciszewski, Anabella Castillo, Kelly Monroe, Joana Torres, Shailja Shah, Jean-Frederic Colombel, Steven Itzkowitz, Rodney Newberry, Russell Cohen, David Rubin, Sarah Cobey, Iris H. Jonkers, Christopher Weber, Joel Pekow, Patrick Wilson, Luis Barreiro
Primary sclerosing cholangitis (PSC) is an autoimmune-like disease of the bile ducts that co-occurs with inflammatory bowel disease (IBD) in almost 90% of cases. Colorectal cancer is a major complication of patients with both PSC and IBD, and these p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::08e35467f666f176758174e816cd8fd7
https://doi.org/10.21203/rs.3.rs-1697242/v1
https://doi.org/10.21203/rs.3.rs-1697242/v1
Autor:
Aarón D. Ramírez-Sánchez, Xiaojing Chu, Rutger Modderman, Yvonne Kooy-Winkelaar, Sibylle Koletzko, Ilma R. Korponay-Szabó, Riccardo Troncone, Cisca Wijmenga, Luisa Mearin, Sebo Withoff, Iris H. Jonkers, Yang Li
Publikováno v:
Frontiers in Immunology, 13:843086. Frontiers Media SA
Frontiers in Immunology, 13. FRONTIERS MEDIA SA
Frontiers in Immunology, 13. FRONTIERS MEDIA SA
Celiac Disease (CeD) is a complex immune disorder involving villous atrophy in the small intestine that is triggered by gluten intake. Current CeD diagnosis is based on late-stage pathophysiological parameters such as detection of specific antibodies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd9858fba83e631585389f7d9dff40b6
https://pubmed.ncbi.nlm.nih.gov/35371081
https://pubmed.ncbi.nlm.nih.gov/35371081
Publikováno v:
MAB, Vol 78, Iss 3, Pp 68-75 (2004)
Application Service Providing (ASP), het op huurbasis aanbieden van software op afstand via bijvoorbeeld het internet, heeft het stadium bereikt dat het een serieuze optie wordt voor kleine en middelgrote ondernemers. Door hun brede inzetbaarheid en
Externí odkaz:
https://doaj.org/article/7996bfa086464a9b9bcd2130bb8cf1b6