Zobrazeno 1 - 10
of 35
pro vyhledávání: '"A. H. J. Scaf"'
Publikováno v:
British Journal of Anaesthesia, 71(3), 393-397. ELSEVIER SCI LTD
We have studied the neuromuscular effects of a 48-h infusion of high-dose pancuronium (400 micrograms kg-1 h-1) in four cats anaesthetized with pentobarbitone, using contraction of tibialis anterior muscles after direct and indirect stimulation. Afte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97e8651b971072fdf1efbb65f7343afa
https://doi.org/10.1093/bja/71.3.393
https://doi.org/10.1093/bja/71.3.393
Autor:
A. H. J. Scaf, Wim E.M. Mol, Jan E. Paanakker, Ferdie Rombout, Roelof Oosting, Dirk K. F. Meijer
Publikováno v:
Biochemical Pharmacology. 44:1453-1459
Both in humans and animals hepatic elimination is an important factor determining the duration of action of non-depolarizing neuromuscular blocking drugs. To elucidate the hepato-biliary disposition of muscle relaxants the pharmacokinetics of several
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd05f4c3747e820752dfccb4ec247937
https://doi.org/10.1016/0006-2952(92)90548-w
https://doi.org/10.1016/0006-2952(92)90548-w
Autor:
J. Mark K. H. Wierda, Wybe D. Kloppenburg, Sandor Agoston, A. H. J. Scaf, Peter J. A. van der Starre, Johannes H. Proost
Publikováno v:
Clinical Pharmacokinetics, 19(6), 491-498. Springer International Publishing AG
Pancuronium is frequently used in coronary artery surgery, but its pharmacokinetics in these patients are still unknown. It is possible that dopamine, administered to prevent renal impairment induced by the surgery, might promote the elimination of p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c22dd6da7e4d4dd964a0ea0194a9734
https://doi.org/10.2165/00003088-199019060-00005
https://doi.org/10.2165/00003088-199019060-00005
Autor:
A. H. J. Scaf, Cee Kuntze, Th. W. Van Der Mark, P. H. J. M. Dunselman, A. Van Bruggen, K. Ing Lie, Harry Wesseling, Johannes Hamer
Publikováno v:
European Heart Journal, 11(3), 200-206. Oxford University Press
We evaluated the cardiopulmonary exercise test results before and after long-term (16 weeks) treatment with the dihydropyridine calcium antagonist, felodipine (10 mg b.i.d., n = 9), and the ACE inhibitor, enalapril (10 mg b.i.d., n = 11), in 20 patie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a847183fb9f675843a1fa2cbf1273e5a
https://doi.org/10.1093/oxfordjournals.eurheartj.a059684
https://doi.org/10.1093/oxfordjournals.eurheartj.a059684
Publikováno v:
European Journal of Clinical Pharmacology, 38(4), 335-341. Springer Verlag
Using available data on time-concentration and time-effect relationships in normal persons the results of infusion of digoxin in various time periods were simulated and compared with administration of digoxin by bolus injections, using a three-compar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eaf6b607aa80d42e933db8fa4d626170
https://doi.org/10.1007/BF00315571
https://doi.org/10.1007/BF00315571
Publikováno v:
European journal of clinical pharmacology. 49(3)
In congestive heart failure patients the kinetics of felodipine, a dihydropyridine calcium antagonist, show interpatient differences after acute i.v. administration that disappear after 8 weeks oral treatment with a change in kinetics in the patients
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::291f1f14a53cf5369715a248a0e744be
https://pubmed.ncbi.nlm.nih.gov/8665996
https://pubmed.ncbi.nlm.nih.gov/8665996
Autor:
P.P. De Deyn, Robert H. Henning, Bart Marescau, J. M. K. H. Wierda, A. H. J. Scaf, Sandor Agoston
Publikováno v:
Clinical Drug investigation, 5(2), 98-107. ADIS INT LTD
Drug investigation
Drug investigation
The sensitivity of patients with chronic renal failure (CRF) to vecuronium was examined by determining plasma concentration-effect relationships at 85% and 60% block during infusion. The log-logit vecuronium plasma concentration-effect curves were sh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d90741f152551bc13b4091f8e34b3a6
https://research.rug.nl/en/publications/12822689-35c9-4eee-b024-d2c4f30093fe
https://research.rug.nl/en/publications/12822689-35c9-4eee-b024-d2c4f30093fe
Autor:
A. H. J. Scaf, Adriaan Nelemans, Adriaan Den Hertog, Robert H. Henning, Joop Van Eekeren, Sandor Agoston
Publikováno v:
European Journal of Pharmacology, 216(1), 73-79. ELSEVIER SCIENCE BV
Unexpectedly, it was observed that the P2-purinoceptor antagonist, suramin (10-mu-M to 1 mM), reversed the muscle paralysis caused by structurally unrelated non-depolarizing relaxants. Suramin competitively reversed the blocking action of pancuronium
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2114495fb1ab3924578064e5e3e45626
https://pubmed.ncbi.nlm.nih.gov/1326440
https://pubmed.ncbi.nlm.nih.gov/1326440
Autor:
A. H. J. Scaf
Publikováno v:
Trends in Pharmacological Sciences, 12(5), 182-185. ELSEVIER SCIENCE LONDON
In pharmacological research and education a barrier often exists between pharmacodynamics and pharmacokinetics. It is helpful to construct models in which pharmacodynamics and pharmacokinetics are linked to improve insight into the situation in vivo.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3404890e1f90a012ba2e4fed4c24ac79
https://pubmed.ncbi.nlm.nih.gov/1677791
https://pubmed.ncbi.nlm.nih.gov/1677791
Autor:
Auke van Bruggen, Bert A. Piers, Kong I. Lie, Henk Beekhuis, C.Erik E Kuntze, Peter H.J.M. Dunselman, Harry Wesseling, A. H. J. Scaf
Publikováno v:
American Heart Journal. 116:1475-1482
To evaluate the necessity of an objective cardiopulmonary exercise test in the selection procedure of patients for heart failure studies, 50 patients with congestive heart failure New York Heart Association (NYHA) class II and III and a left ventricu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0df31968f954a253ba6e9e508f59588f
https://doi.org/10.1016/0002-8703(88)90731-4
https://doi.org/10.1016/0002-8703(88)90731-4