Pulmonary inflammation promoted by type-2 dendritic cells is a feature of human and murine schistosomiasis

Autor: E. L. Houlder, A. H. Costain, I. Nambuya, S. L. Brown, J. P. R. Koopman, M. C. C. Langenberg, J. J. Janse, M. A. Hoogerwerf, A. J. L. Ridley, J. E. Forde-Thomas, S. A. P. Colombo, B. M. F. Winkel, A. A. Galdon, K. F. Hoffmann, P. C. Cook, M. Roestenberg, H. Mpairwe, A. S. MacDonald

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)

Schistosomiasis, a parasitic helminth infection, causes pulmonary symptoms during acute and chronic infection. Here, Houlder et al characterise the pulmonary immune response and demonstrate the role type 2 dendritic cells play in lung inflammation.

Externí odkaz: https://doaj.org/article/f2549630402c40a3814cbbc16588cdcc

Corrigendum: Schistosome Egg Migration: Mechanisms, Pathogenesis and Host Immune Responses

Autor: Alice H. Costain, Andrew S. MacDonald, Hermelijn H. Smits

Publikováno v: Frontiers in Immunology, Vol 10 (2019)

Externí odkaz: https://doaj.org/article/97443588afdb4d5cadce1217f1352c01

Plasmacytoid Dendritic Cells Facilitate Th Cell Cytokine Responses throughout Schistosoma mansoni Infection

Autor: Alexander T. Phythian-Adams, Alice H. Costain, Angela K. Marley, Sheila Brown, Lucy H. Jackson-Jones, Hermelijn H. Smits, Andrew S. MacDonald, Peter C. Cook, Josephine Forde-Thomas, Karl F. Hoffmann, Lauren M. Webb, Elia D. Tait Wojno, Rachel J. Lundie

Publikováno v: Immunohorizons
Webb, L M, Phythian-adams, A T, Costain, A H, Brown, S L, Lundie, R J, Forde-thomas, J, Cook, P C, Jackson-jones, L H, Marley, A K, Smits, H H, Hoffmann, K F, Tait Wojno, E D & Macdonald, A S 2021, ' Plasmacytoid Dendritic Cells Facilitate Th Cell Cytokine Responses throughout Schistosoma mansoni Infection ', ImmunoHorizons, vol. 5, no. 8, pp. 721-732 . https://doi.org/10.4049/immunohorizons.2100071

Plasmacytoid dendritic cells (pDCs) are potent producers of type I IFN (IFN-I) during viral infection and respond to IFN-I in a positive feedback loop that promotes their function. IFN-I shapes dendritic cell responses during helminth infection, impa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67bd53168b0130cde7ffe2572d4fa109
https://doi.org/10.4049/immunohorizons.2100071

Schistosomes in the Lung: Immunobiology and Opportunity

Autor: Alice H. Costain, Andrew S. MacDonald, Peter C. Cook, Emma L Houlder

Publikováno v: Frontiers in Immunology
Houlder, E L, Costain, A H, Cook, P C & MacDonald, A S 2021, ' Schistosomes in the Lung : Immunobiology and Opportunity ', Frontiers in Immunology, vol. 12, 635513, pp. 635513 . https://doi.org/10.3389/fimmu.2021.635513
Frontiers in Immunology, Vol 12 (2021)

Schistosome infection is a major cause of global morbidity, particularly in sub-Saharan Africa. However, there is no effective vaccine for this major neglected tropical disease, and re-infection routinely occurs after chemotherapeutic treatment. Foll

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::519936ed87300eb05781cf50e0224d44
https://pubmed.ncbi.nlm.nih.gov/33953712

Schistosome egg migration: mechanisms, pathogenesis and host immune responses

Autor: Hermelijn H. Smits, Alice H. Costain, Andrew S. MacDonald

Publikováno v: Smits, H H, Costain, A & MacDonald, A 2018, ' Schistosome egg migration: mechanisms, pathogenesis and host immune responses ', Frontiers in Immunology . https://doi.org/10.3389/fimmu.2018.03042
Frontiers in Immunology
Frontiers in Immunology, 9
Frontiers in Immunology, Vol 9 (2018)

Many parasitic worms possess complex and intriguing life cycles, and schistosomes are no exception. To exit the human body and progress to their successive snail host, Schistosoma mansoni eggs must migrate from the mesenteric vessels, across the inte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36f522cd5ccfbca67c63bad6f7f7e21a
https://www.research.manchester.ac.uk/portal/en/publications/schistosome-egg-migration-mechanisms-pathogenesis-and-host-immune-responses(b0e38270-1a66-45a7-b690-c3d310eedd16).html