Zobrazeno 1 - 10
of 275
pro vyhledávání: '"A. H. Caruthers"'
Autor:
T. R. Them II, J. D. Owens, S. M. Marroquín, A. H. Caruthers, J. P. Trabucho Alexandre, B. C. Gill
Publikováno v:
AGU Advances, Vol 3, Iss 6, Pp n/a-n/a (2022)
Abstract Many metals present in trace concentrations in the oceans are sensitive to reduction and oxidation reactions (termed redox‐sensitive trace metals or RSTMs) and can therefore be affected during intervals of expanded oceanic anoxia and euxin
Externí odkaz:
https://doaj.org/article/eec091f20c65417f8e49942a1e030449
Autor:
Amy E. Campbell, Michael C. Dyle, Roberto Albanese, Tyler Matheny, Kavitha Sudheendran, Michael A. Cortázar, Thomas Forman, Rui Fu, Austin E. Gillen, Marvin H. Caruthers, Stephen N. Floor, Lorenzo Calviello, Sujatha Jagannathan
Publikováno v:
Cell Reports, Vol 42, Iss 6, Pp 112642- (2023)
Summary: Nonsense-mediated RNA decay (NMD) degrades transcripts carrying premature termination codons. NMD is thought to prevent the synthesis of toxic truncated proteins. However, whether loss of NMD results in widespread production of truncated pro
Externí odkaz:
https://doaj.org/article/df0dd2523a6149e2baba95596b1500ad
Autor:
Sibasish Paul, Marvin H. Caruthers
Publikováno v:
Molecules, Vol 28, Iss 14, p 5380 (2023)
Phosphorodiamidate morpholinos (PMOs) are known as premier gene knockdown tools in developmental biology. PMOs are usually 25 nucleo-base-long morpholino subunits with a neutral phosphorodiamidate linkage. PMOs work via a steric blocking mechanism an
Externí odkaz:
https://doaj.org/article/f7e890abb3df4a1f91a46fcb954fff86
Autor:
T. R. Them, J. D. Owens, S. M. Marroquín, A. H. Caruthers, J. P. Trabucho Alexandre, B. C. Gill
Many metals present in trace concentrations in the oceans are sensitive to reduction and oxidation reactions (termed redox-sensitive trace metals or RSTMs) and can therefore be affected during intervals of expanded oceanic anoxia and euxinia (anoxic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3594e86cb1c8980d347af551a902859
https://hdl.handle.net/10919/112946
https://hdl.handle.net/10919/112946
Autor:
Bao T. Le, Sibasish Paul, Katarzyna Jastrzebska, Heera Langer, Marvin H. Caruthers, Rakesh N. Veedu
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(36)
Recent advances in drug development have seen numerous successful clinical translations using synthetic antisense oligonucleotides (ASOs). However, major obstacles, such as challenging large-scale production, toxicity, localization of oligonucleotide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b56fc4d244ce7b6ab11611e318beca4
https://pubmed.ncbi.nlm.nih.gov/36037350
https://pubmed.ncbi.nlm.nih.gov/36037350
Publikováno v:
Journal of the American Chemical Society. 142:16240-16253
This Article outlines the optimized chemical synthesis and preliminary biochemical characterization of a new oligonucleotide analogue called thiophosphoramidate morpholinos (TMOs). Their rational design hinges upon integrating two well-studied pharma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ce90a19003ff244647641fce6baac89
https://doi.org/10.1021/jacs.0c04335
https://doi.org/10.1021/jacs.0c04335
Autor:
Benjamin C. Gill, Darren R. Gröcke, Runsheng Yin, C. H. Jagoe, Theodore R. Them, Jeremy D. Owens, Stephen E. Grasby, Andrew H. Caruthers
Publikováno v:
Earth and planetary science letters, 2018, Vol.507, pp.62-72 [Peer Reviewed Journal]
This study evaluates the utility of sedimentary mercury (Hg) contents as a proxy for fingerprinting ancient massive volcanism, which is often associated with biogeochemical perturbations. Herein we present new Hg geochemical data from anoxic marine b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8a0c337a2cecb8154ffe616b4f9b18b
https://doi.org/10.1016/j.epsl.2018.11.029
https://doi.org/10.1016/j.epsl.2018.11.029
Autor:
Amy E. Campbell, Michael C. Dyle, Lorenzo Calviello, Tyler Matheny, Kavitha Sudheendran, Michael A. Cortazar, Thomas Forman, Rui Fu, Austin E. Gillen, Marvin H. Caruthers, Stephen N. Floor, Sujatha Jagannathan
Nonsense-mediated RNA decay (NMD) is a surveillance mechanism that degrades both canonical and aberrant transcripts carrying premature translation termination codons. NMD is thought to have evolved to prevent the synthesis of toxic truncated proteins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::47d1e35295b3d46515ea341d82d00715
https://doi.org/10.1101/2021.06.28.450189
https://doi.org/10.1101/2021.06.28.450189
Autor:
John L. Rinn, Evan P. Hass, Marvin H. Caruthers, Katarzyna Jastrzebska, Josep Biayna, Ulrich Braunschweig, Heera K. Langner, Gabrijela Dumbovic, Benjamin J. Blencowe, Michael J. Smallegan, Thomas R. Cech
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
The spatial partitioning of the transcriptome in the cell is an important form of gene-expression regulation. Here, we address how intron retention influences the spatio-temporal dynamics of transcripts from two clinically relevant genes: TERT (Telom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf5077cf0354d59af55e2f2076738a02
http://europepmc.org/articles/PMC8175569
http://europepmc.org/articles/PMC8175569
Autor:
Selva M. Marroquín, Kayla McCabe, Darren R. Gröcke, Andrew H. Caruthers, Martin Aberhan, Theodore R. Them, Yorick Veenma, Jeremy D. Owens, Martyn Golding, João Trabucho Alexandre, Benjamin C. Gill
Publikováno v:
Geological Society of America Abstracts with Programs.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::941cd94009971fe5970949faf6cce024
https://doi.org/10.1130/abs/2021am-368955
https://doi.org/10.1130/abs/2021am-368955