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pro vyhledávání: '"A. Gorins"'
Autor:
Gilles Gorins, Matthew M. Bio, John T. Colyer, Jason S. Tedrow, Maria Victoria Silva Elipe, Austin G. Smith, Shawn D. Walker, Seb Caille, Jones Sian, Khalid Diker
Publikováno v:
Organic Process Research & Development. 24:1164-1174
We describe herein the development of a scalable Noyori reductive dynamic kinetic resolution to manufacture DLAC, a Δ-lactone precursor to the active pharmaceutical ingredient AMG 232. Central to t...
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Autor:
Gorins, A *, Espié, M, Bedairia, N, Perret, F, Tournant, B, Novak, H, Lucchi-Angelier, E, Marty, M
Publikováno v:
In Gynécologie Obstétrique & Fertilité 2003 31(7):614-619
Autor:
John R. Huckins, Khalid Diker, Gilles Gorins, Richard D. Crockett, Robert P. Farrell, Caroline Affouard, Seb Caille
Publikováno v:
Organic Process Research & Development. 19:476-485
The development of a synthetic route to manufacture the drug candidate AMG 925 on kilogram scale is reported herein. The hydrochloride salt of AMG 925 was prepared in 23% overall yield over eight steps from commercially available raw materials, and m
Autor:
Cottu, P.H., Cojean-Zelek, I., Bourstyn, E., de Roquancourt, A., Extra, J.M., Perret, F., Gorins, A., Marty, M., Espié, M.
Publikováno v:
In La Revue de médecine interne 2000 21(4):337-343
Autor:
Michal Achmatowicz, Gilles Gorins, Oliver R. Thiel, Randy Jensen, Robert D. Larsen, Caroline Affouard, Corinne Goldstein
Publikováno v:
The Journal of Organic Chemistry. 73:6793-6799
An efficient and scalable three-step one-pot approach to 6-methyl-5-nitroisoquinoline (1) from inexpensive 5-nitroisoquinoline, utilizing the vicarious nucleophilic substitution (VNS) as a key step, is described. The optimized reaction conditions can
Autor:
Bertrand Tournant, Marc Espié, H Novak, André Gorins, E Lucchi-Angelier, F. Perret, Michel Marty, N Bedairia
Publikováno v:
Gynécologie Obstétrique & Fertilité. 31:614-619
Resume Objectifs. – Apres avoir rappele la contre-indication classique du THS chez les femmes ayant un antecedent personnel de cancer du sein, et les arguments qui lui sont opposables, les auteurs rapportent les resultats actuels de l’etude prosp
Autor:
A. Gorins, F. Perret, J.M. Extra, PH Cottu, Michel Marty, Isabelle Cojean-Zelek, E. Bourstyn, A. De Roquancourt, Marc Espié
Publikováno v:
La Revue de Médecine Interne. 21:337-343
Resume Propos De nombreuses etudes tendent a montrer l'efficacite du depistage mammographique du cancer du sein, notamment sur la survie. Nous rapportons deux annees d'experience de l'exerese apres reperage radiologique de lesions mammaires depistees
Publikováno v:
Journal of Medicinal Chemistry. 39:4871-4878
A series of (carboxyalkyl)benzyl propargyl ethers was synthesized and tested as inhibitors of 12-lipoxygenase (12-LO) from porcine leukocyte cytosol. Optimum activity was displayed by 3-[4-[(2-tridecynyloxy)methyl]phenyl]propanoic acid. Altering the