Zobrazeno 1 - 10
of 7 548
pro vyhledávání: '"A. Gilkes"'
Autor:
N. Russell, C. Wilhelm-Benartzi, J. Othman, R. Dillon, N. Potter, J. Jovanovic, A. Gilkes, L. M. Batten, J. Canham, E. L. Hinson, P. Kottaridis, J. Cavenagh, C. Arnold, M. Dennis, S. Knapper
Publikováno v:
HemaSphere, Vol 6, Pp 27-28 (2022)
Externí odkaz:
https://doaj.org/article/640a2b90737542798c43eb953871ad0e
Predicting the degradation processes of molecules over long timescales is a key aspect of industrial materials design. However, it is made computationally challenging by the need to construct large networks of chemical reactions that are relevant to
Externí odkaz:
http://arxiv.org/abs/2403.08657
Autor:
Inês Godet, Harsh H. Oza, Yi Shi, Natalie S. Joe, Alyssa G. Weinstein, Jeanette Johnson, Michael Considine, Swathi Talluri, Jingyuan Zhang, Reid Xu, Steven Doctorman, Delma Mbulaiteye, Genevieve Stein-O’Brien, Luciane T. Kagohara, Cesar A. Santa-Maria, Elana J. Fertig, Daniele M. Gilkes
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Hypoxia occurs in 90% of solid tumors and is associated with metastasis and mortality. Breast cancer cells that experience intratumoral hypoxia are 5x more likely to develop lung metastasis in animal models. Using spatial transcriptomics, we
Externí odkaz:
https://doaj.org/article/426e0d8a44dd43e7bc5d581380aed53f
Autor:
Varsamis, G. D., Karafyllidis, I. G., Gilkes, K. M., Arranz, U., Martin-Cuevas, R., Calleja, G., Dimitrakis, P., Kolovos, P., Sandaltzopoulos, R., Jessen, H. C., Wong, J.
Publikováno v:
Computational Biology and Chemistry, Volume 107, 2023, 107959
Reference-guided DNA sequencing and alignment is an important process in computational molecular biology. The amount of DNA data grows very fast, and many new genomes are waiting to be sequenced while millions of private genomes need to be re-sequenc
Externí odkaz:
http://arxiv.org/abs/2308.04525
Autor:
Varsamis, G. D., Karafyllidis, I. G., Gilkes, K. M., Arranz, U., Martin-Cuevas, R., Calleja, G., Wong, J., Jessen, H. C., Dimitrakis, P., Kolovos, P., Sandaltzopoulos, R.
De novo DNA sequence assembly is based on finding paths in overlap graphs, which is a NP-hard problem. We developed a quantum algorithm for de novo assembly based on quantum walks in graphs. The overlap graph is partitioned repeatedly to smaller grap
Externí odkaz:
http://arxiv.org/abs/2308.03532
Autor:
Randa Ghazal Asswad, Muhammad Ilyas Khan, Catherine Elizabeth Gilkes, Christina Daousi, Sravan Kumar Thondam
Publikováno v:
Endocrinology, Diabetes & Metabolism Case Reports, Vol 1, Iss 1, Pp 1-5 (2024)
Functioning gonadotroph adenomas with clinical manifestations are extremely rare and the majority of these are FSH-secreting macroadenomas. Clinical symptoms are due to excess gonadotrophins and sex hormones, and these may be present for a long time
Externí odkaz:
https://doaj.org/article/db48c392ac9e4b9f87cc4032e0b5005b
Publikováno v:
Nature Computational Science (2023)
The design of molecules and materials with tailored properties is challenging, as candidate molecules must satisfy multiple competing requirements that are often difficult to measure or compute. While molecular structures, produced through generative
Externí odkaz:
http://arxiv.org/abs/2207.01476
Autor:
Zachary J. Rogers, Thibault Colombani, Saad Khan, Khushbu Bhatt, Alexandra Nukovic, Guanyu Zhou, Benjamin M. Woolston, Cormac T. Taylor, Daniele M. Gilkes, Nikolai Slavov, Sidi A. Bencherif
Publikováno v:
Advanced Science, Vol 11, Iss 30, Pp n/a-n/a (2024)
Abstract In oxygen (O2)‐controlled cell culture, an indispensable tool in biological research, it is presumed that the incubator setpoint equals the O2 tension experienced by cells (i.e., pericellular O2). However, it is discovered that physioxic (
Externí odkaz:
https://doaj.org/article/1068060eb74c48a59b7780c76e69d254
Autor:
Othman, Jad, Potter, Nicola, Ivey, Adam, Tazi, Yanis, Papaemmanuil, Elli, Jovanovic, Jelena, Freeman, Sylvie D., Gilkes, Amanda, Gale, Rosemary, Rapoz-D’Silva, Tanya, Runglall, Manohursingh, Kleeman, Michelle, Dhami, Pawan, Thomas, Ian, Johnson, Sean, Canham, Joanna, Cavenagh, Jamie, Kottaridis, Panagiotis, Arnold, Claire, Ommen, Hans Beier, Overgaard, Ulrik Malthe, Dennis, Mike, Burnett, Alan, Wilhelm-Benartzi, Charlotte, Huntly, Brian, Russell, Nigel H., Dillon, Richard
Publikováno v:
In Blood 15 August 2024 144(7):714-728
Autor:
Brittany P. Todd, Zili Luo, Noah Gilkes, Michael S. Chimenti, Zeru Peterson, Madison R. Mix, John T. Harty, Thomas Nickl-Jockschat, Polly J. Ferguson, Alexander G. Bassuk, Elizabeth A. Newell
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-16 (2023)
Abstract Accumulating evidence suggests that type I interferon (IFN-I) signaling is a key contributor to immune cell-mediated neuropathology in neurodegenerative diseases. Recently, we demonstrated a robust upregulation of type I interferon-stimulate
Externí odkaz:
https://doaj.org/article/8c8d670c025e4719a03715fdbd6ee349