Zobrazeno 1 - 10
of 894
pro vyhledávání: '"A. Geard"'
Autor:
L. Poupon-Bejuit, M. P. Hughes, W. Liu, A. Geard, N. Faour-Slika, S. Whaler, G. Massaro, A. A. Rahim
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-17 (2022)
Abstract Infantile neuroaxonal dystrophy (INAD) is a rare paediatric neurodegenerative condition caused by mutations in the PLA2G6 gene, which is also the causative gene for PARK14-linked young adult-onset dystonia parkinsonism. INAD patients usually
Externí odkaz:
https://doaj.org/article/d8580e681da640008ec304a84850d936
Autor:
Harris, Thomas, Jayasundara, Pavithra, Ragonnet, Romain, Trauer, James, Geard, Nicholas, Zachreson, Cameron
Social contact patterns are key drivers of infectious disease transmission. During the COVID-19 pandemic, differences between pre-COVID and COVID-era contact rates were widely attributed to non-pharmaceutical interventions such as lockdowns. However,
Externí odkaz:
http://arxiv.org/abs/2406.01639
Autor:
Zachreson, Cameron, Tobin, Ruarai, Walker, Camelia, Conway, Eamon, Shearer, Freya M, McVernon, Jodie, Geard, Nicholas
Residential aged-care facilities (RACFs, also called long-term care facilities, aged care homes, or nursing homes) have elevated risks of respiratory infection outbreaks and associated disease burden. During the COVID-19 pandemic, social isolation po
Externí odkaz:
http://arxiv.org/abs/2401.01371
Antibodies, a prominent class of approved biologics, play a crucial role in detecting foreign antigens. The effectiveness of antigen neutralisation and elimination hinges upon the strength, sensitivity, and specificity of the paratope-epitope interac
Externí odkaz:
http://arxiv.org/abs/2309.01122
Autor:
Cameron Zachreson, Ruarai Tobin, Camelia Walker, Eamon Conway, Freya M. Shearer, Jodie McVernon, Nicholas Geard
Publikováno v:
BMC Infectious Diseases, Vol 24, Iss 1, Pp 1-13 (2024)
Abstract Background Residential aged-care facilities (RACFs, also called long-term care facilities, aged care homes, or nursing homes) have elevated risks of respiratory infection outbreaks and associated disease burden. During the COVID-19 pandemic,
Externí odkaz:
https://doaj.org/article/5125465ac5e843f9a96065a9f4d33eb3
Autor:
Michael J. Lydeamore, Tjibbe Donker, David Wu, Claire Gorrie, Annabelle Turner, Marion Easton, Daneeta Hennessy, Nicholas Geard, Benjamin P. Howden, Ben S. Cooper, Andrew Wilson, Anton Y. Peleg, Andrew J. Stewardson
Publikováno v:
Antimicrobial Resistance and Infection Control, Vol 13, Iss 1, Pp 1-9 (2024)
Abstract Background Hospitals in any given region can be considered as part of a network, where facilities are connected to one another – and hospital pathogens potentially spread – through the movement of patients between them. We sought to desc
Externí odkaz:
https://doaj.org/article/e9eb7542fcf1483897026552b58e951d
Early estimates of the transmission properties of a newly emerged pathogen are critical to an effective public health response, and are often based on limited outbreak data. Here, we use simulations to investigate a potential source of bias in such e
Externí odkaz:
http://arxiv.org/abs/2211.08673
Autor:
Laura Poupon-Bejuit, Amy Geard, Nathan Millicheap, Eridan Rocha-Ferreira, Henrik Hagberg, Claire Thornton, Ahad A Rahim
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 6, Pp 1284-1309 (2024)
Abstract Hypoxic-ischaemic encephalopathy (HIE) arises from diminished blood flow and oxygen to the neonatal brain during labor, leading to infant mortality or severe brain damage, with a global incidence of 1.5 per 1000 live births. Glucagon-like Pe
Externí odkaz:
https://doaj.org/article/755beec1f79d489494da254d818c003f
Publikováno v:
In Computers in Biology and Medicine November 2024 182
Publikováno v:
Bioinformatics 38.22 (2022) 5026-5032
Survival risk prediction using gene expression data is important in making treatment decisions in cancer. Standard neural network (NN) survival analysis models are black boxes with lack of interpretability. More interpretable visible neural network (
Externí odkaz:
http://arxiv.org/abs/2202.00882