Výsledky vyhledávání - "A. Gaigneaux"

Akademický článek

IL1R1+ cancer-associated fibroblasts drive tumor development and immunosuppression in colorectal cancer

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)

Abstract Fibroblasts have a considerable functional and molecular heterogeneity and can play various roles in the tumor microenvironment. Here we identify a pro-tumorigenic IL1R1+, IL-1-high-signaling subtype of fibroblasts, using multiple colorectal

Externí odkaz: https://doaj.org/article/82addcedbdd2496da008d9fb3de1053a

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Akademický článek

Identification of an H-Ras nanocluster disrupting peptide

Autor: Candy Laura Steffen, Ganesh babu Manoharan, Karolina Pavic, Alejandro Yeste-Vázquez, Matias Knuuttila, Neha Arora, Yong Zhou, Harri Härmä, Anthoula Gaigneaux, Tom N. Grossmann, Daniel Kwaku Abankwa

Publikováno v: Communications Biology, Vol 7, Iss 1, Pp 1-15 (2024)

Abstract Hyperactive Ras signalling is found in most cancers. Ras proteins are only active in membrane nanoclusters, which are therefore potential drug targets. We previously showed that the nanocluster scaffold galectin-1 (Gal1) enhances H-Ras nanoc

Externí odkaz: https://doaj.org/article/824fba21fa7f4eef9a59a3a33f13cb35

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