Zobrazeno 1 - 10
of 273
pro vyhledávání: '"A. G. de la Campa"'
Publikováno v:
Frontiers in Microbiology, Vol 13 (2023)
Two enzymes are responsible for maintaining supercoiling in the human pathogen Streptococcus pneumoniae, gyrase (GyrA2GyrB2) and topoisomerase I. To attain diverse levels of topoisomerase I (TopoI, encoded by topA), two isogenic strains derived from
Externí odkaz:
https://doaj.org/article/cfc058b24dac4902a173c4ebf2b59885
Publikováno v:
Antibiotics, Vol 11, Iss 12, p 1837 (2022)
PatAB is an ABC bacterial transporter that facilitates the export of antibiotics and dyes. The overexpression of patAB genes conferring efflux-mediated fluoroquinolone resistance has been observed in several laboratory strains and clinical isolates o
Externí odkaz:
https://doaj.org/article/2d4f32afd1ea417288483c8c6362982e
Publikováno v:
PLoS Genetics, Vol 17, Iss 4, p e1009542 (2021)
Streptococcus pneumoniae is a major cause of disease and death that develops resistance to multiple antibiotics. DNA topoisomerase I (TopoI) is a novel pneumococcal drug target. TopoI is the sole type-I pneumococcal topoisomerase that regulates super
Externí odkaz:
https://doaj.org/article/c1a25e74551142e4b98eab21e23fbe00
Autor:
Rodrigo Sánchez-Tarjuelo, Isabel Cortegano, Juliana Manosalva, Mercedes Rodríguez, Carolina Ruíz, Mario Alía, María Carmen Prado, Eva M. Cano, María José Ferrándiz, Adela G. de la Campa, María Luisa Gaspar, Belén de Andrés
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Streptococcus pneumoniae is the main cause of bacterial pneumonia, a condition that currently produces significant global morbidity and mortality. The initial immune response to this bacterium occurs when the innate system recognizes common motifs ex
Externí odkaz:
https://doaj.org/article/a1e658d49c294935a0963c7bbcb0207f
Autor:
Myriam V Valenzuela, Mirian Domenech, Patricia Mateos-Martínez, Fernando González-Camacho, Adela G de la Campa, Maria Teresa García
Publikováno v:
PLoS ONE, Vol 15, Iss 11, p e0241780 (2020)
The DNA topoisomerase complement of Streptococcus pneumoniae is constituted by two type II enzymes (topoisomerase IV and gyrase), and a single type I enzyme (topoisomerase I). These enzymes maintain the DNA topology, which is essential for replicatio
Externí odkaz:
https://doaj.org/article/bfeebf25864e4a428c1b52f1ea58a734
Publikováno v:
eXPRESS Polymer Letters, Vol 12, Iss 5, Pp 479-489 (2018)
A series of aromatic polyimides has been obtained by the reaction of two dianhydrides, the commercial 2,2′-bis(3,4-dicarboxyphenyl)hexafluoropropane dianhydride (6FDA) and another having a 5′-tert-butyl-m-terphenyl moiety (BTPDA), with several di
Externí odkaz:
https://doaj.org/article/c2df1480ab3a4d8db8a13992ee5e960c
Autor:
Jose Manuel Tirado-Vélez, David Carreño, David Sevillano, Luis Alou, José Yuste, Adela G. de la Campa
Publikováno v:
Antibiotics, Vol 10, Iss 5, p 573 (2021)
Antibiotic resistance in Streptococcus pneumoniae has increased worldwide, making fluoroquinolones an alternative therapeutic option. Fluoroquinolones inhibit the type II DNA topoisomerases (topoisomerase IV and gyrase). In this study we have evaluat
Externí odkaz:
https://doaj.org/article/5b7a65b8d6b0468da794a1ec4d399a0f
Autor:
Antonio J. Martín-Galiano, María S. Escolano-Martínez, Bruno Corsini, Adela G. de la Campa, José Yuste
Publikováno v:
Vaccines, Vol 9, Iss 3, p 187 (2021)
Knowledge-based vaccinology can reveal uncharacterized antigen candidates for a new generation of protein-based anti-pneumococcal vaccines. DiiA, encoded by the sp_1992 locus, is a surface protein containing either one or two repeats of a 37mer N-ter
Externí odkaz:
https://doaj.org/article/fc1bd746dd9b4593b7e89f3ba1b0b31d
Autor:
Antonio A. de Vasconcelos Junior, Jose M. Tirado-Vélez, Antonio J. Martín-Galiano, Diego Megias, María-José Ferrándiz, Pablo Hernández, Mónica Amblar, Adela G. de la Campa
Publikováno v:
International Journal of Molecular Sciences; Volume 24; Issue 6; Pages: 5973
The DNA topoisomerases gyrase and topoisomerase I as well as the nucleoid-associated protein HU maintain supercoiling levels in Streptococcus pneumoniae, a main human pathogen. Here, we characterized, for the first time, a topoisomerase I regulator p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0fad920ae936d7d7b200fde79b8f506
http://hdl.handle.net/10261/308017
http://hdl.handle.net/10261/308017
Autor:
Laura Matesanz-Niño, David Cuellas, Carla Aguilar-Lugo, Laura Palacio, Alfonso González-Ortega, José G. de la Campa, Cristina Álvarez, Ángel E. Lozano
Publikováno v:
Polymers; Volume 15; Issue 6; Pages: 1333
An optimized synthesis of the monomer 2,2′3,3′-biphenyltetracarboxylic dianhydride, iBPDA, was performed to obtain high molecular weight polymers. This monomer has a contorted structure that produces a non-linear shape, hindering the packing of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50ef2d37e96886e50f6f755d48acd361
http://hdl.handle.net/10261/330519
http://hdl.handle.net/10261/330519