Zobrazeno 1 - 10
of 1 522
pro vyhledávání: '"A. G. Shepherd"'
Autor:
S. Sippel, C. Barnes, C. Cadiou, E. Fischer, S. Kew, M. Kretschmer, S. Philip, T. G. Shepherd, J. Singh, R. Vautard, P. Yiou
Publikováno v:
Weather and Climate Dynamics, Vol 5, Pp 943-957 (2024)
Central European winters have warmed markedly since the mid-20th century. Yet cold winters are still associated with severe societal impacts on energy systems, infrastructure, and public health. It is therefore crucial to anticipate storylines of wor
Externí odkaz:
https://doaj.org/article/55a48402ba5f4f9cbc29e9a1d39c246a
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-20 (2024)
Abstract Liver Kinase B1 (LKB1), encoded by Serine-Threonine Kinase 11 (STK11), is a master kinase that regulates cell migration, polarity, proliferation, and metabolism through downstream adenosine monophosphate-activated protein kinase (AMPK) and A
Externí odkaz:
https://doaj.org/article/177eccc9e3384d40af0f4e11a5e253a0
Publikováno v:
Genes and Diseases, Vol 12, Iss 2, Pp 101402- (2025)
Genetic alterations to serine-threonine kinase 11 (STK11) have been implicated in Peutz-Jeghers syndrome and tumorigenesis. Further exploration of the context-specific roles of liver kinase B1 (LKB1; encoded by STK11) observed that it regulates AMP-a
Externí odkaz:
https://doaj.org/article/1fa32904b88e42e69779798b03317cf7
Publikováno v:
Frontiers in Astronomy and Space Sciences, Vol 11 (2024)
The phenomenon known as strong thermal emission velocity enhancement (STEVE) is a narrow optical structure that may extend longitudinally for thousands of kilometers. Initially observed by amateur photographers, it has recently garnered researchers
Externí odkaz:
https://doaj.org/article/8122643a6cd24f6189dc84c8fd787bc6
Autor:
James G Shepherd, Shirin Ashraf, Jesus F Salazar-Gonzalez, Maria G Salazar, Robert G Downing, Henry Bukenya, Hanna Jerome, Joseph T Mpanga, Chris Davis, Lily Tong, Vattipally B Sreenu, Linda A Atiku, Nicola Logan, Ezekiel Kajik, Yafesi Mukobi, Cyrus Mungujakisa, Michael V Olowo, Emmanuel Tibo, Fred Wunna, Hollie Jackson Ireland, Andrew E Blunsum, Iyanuoluwani Owolabi, Ana da Silva Filipe, Josephine Bwogi, Brian J Willett, Julius J Lutwama, Daniel G Streicker, Pontiano Kaleebu, Emma C Thomson
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 18, Iss 7, p e0012297 (2024)
Le Dantec virus (LDV), assigned to the species Ledantevirus ledantec, genus Ledantevirus, family Rhabdoviridae has been associated with human disease but has gone undetected since the 1970s. We describe the detection of LDV in a human case of undiffe
Externí odkaz:
https://doaj.org/article/85464e48cbbd4c34a14d890e9ac28189
Autor:
Pirunthan Perampalam, James I MacDonald, Komila Zakirova, Daniel T Passos, Sumaiyah Wasif, Yudith Ramos-Valdes, Maeva Hervieu, Patrick Mehlen, Rob Rottapel, Benjamin Gibert, Rohann JM Correa, Trevor G Shepherd, Frederick A Dick
Publikováno v:
eLife, Vol 12 (2024)
Dormancy in cancer is a clinical state in which residual disease remains undetectable for a prolonged duration. At a cellular level, rare cancer cells cease proliferation and survive chemotherapy and disseminate disease. We created a suspension cultu
Externí odkaz:
https://doaj.org/article/fb52aec78d484fa7a44a296e56c0db33
Publikováno v:
Natural Hazards and Earth System Sciences, Vol 24, Pp 1065-1078 (2024)
The UK has experienced recurring periods of hydrological droughts in the past, including the drought declared in summer 2022. Seasonal hindcasts, consisting of a large sample of plausible weather sequences, can be used to create drought storylines an
Externí odkaz:
https://doaj.org/article/249f1523760a45889e288883bf2f6879
Autor:
Tiffany A. Shaw, Paola A. Arias, Mat Collins, Dim Coumou, Arona Diedhiou, Chaim I. Garfinkel, Shipra Jain, Mathew Koll Roxy, Marlene Kretschmer, L. Ruby Leung, Sugata Narsey, Olivia Martius, Richard Seager, Theodore G. Shepherd, Anna A. Sörensson, Tannecia Stephenson, Michael Taylor, Lin Wang
Publikováno v:
Frontiers in Climate, Vol 6 (2024)
Climate change has emerged across many regions. Some observed regional climate changes, such as amplified Arctic warming and land-sea warming contrasts have been predicted by climate models. However, many other observed regional changes, such as chan
Externí odkaz:
https://doaj.org/article/7b8fd646f1d046658dc4b46a10ed9cea
Publikováno v:
Journal of Ovarian Research, Vol 16, Iss 1, Pp 1-16 (2023)
Abstract High-grade serous carcinoma (HGSC) is the most common and aggressive subtype of epithelial ovarian cancer, characterized by gain-of-function TP53 mutations originating in the fallopian tube epithelium. Therapeutic intervention occurs at adva
Externí odkaz:
https://doaj.org/article/c7bf5f55cad149e0a8bb3f0ae7f7d9d6
Autor:
David P. Cook, Kristianne J. C. Galpin, Galaxia M. Rodriguez, Noor Shakfa, Juliette Wilson-Sanchez, Maryam Echaibi, Madison Pereira, Kathy Matuszewska, Jacob Haagsma, Humaira Murshed, Alison O. Cudmore, Elizabeth MacDonald, Alicia Tone, Trevor G. Shepherd, James J. Petrik, Madhuri Koti, Barbara C. Vanderhyden
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-11 (2023)
Abstract Ovarian cancers exhibit high rates of recurrence and poor treatment response. Preclinical models that recapitulate human disease are critical to develop new therapeutic approaches. Syngeneic mouse models allow for the generation of tumours c
Externí odkaz:
https://doaj.org/article/f661987fb8f3474ebc28deb27ada3401