Zobrazeno 1 - 10
of 234
pro vyhledávání: '"A. G. Rudd"'
Autor:
Miriam Yagüe-Capilla, Sean G. Rudd
Publikováno v:
Disease Models & Mechanisms, Vol 17, Iss 8 (2024)
Externí odkaz:
https://doaj.org/article/a9e5c8a9c2f34d0ea04b807185845130
Autor:
Si Min Zhang, Cynthia B.J. Paulin, Huazhang Shu, Miriam Yagüe-Capilla, Maurice Michel, Petra Marttila, Florian Ortis, Henri Colyn Bwanika, Christopher Dirks, Rajagopal Papagudi Venkatram, Elisée Wiita, Ann-Sofie Jemth, Ingrid Almlöf, Olga Loseva, Femke M. Hormann, Tobias Koolmeister, Erika Linde, Sun Lee, Sabin Llona-Minguez, Martin Haraldsson, Hanna Axelsson, Kia Strömberg, Evert J. Homan, Martin Scobie, Thomas Lundbäck, Thomas Helleday, Sean G. Rudd
Publikováno v:
iScience, Vol 27, Iss 2, Pp 108907- (2024)
Summary: SAMHD1 is a dNTP triphosphohydrolase governing nucleotide pool homeostasis and can detoxify chemotherapy metabolites controlling their clinical responses. To understand SAMHD1 biology and investigate the potential of targeting SAMHD1 as neoa
Externí odkaz:
https://doaj.org/article/62a8b016c8c04843b50875f18c4706f6
Autor:
Thomas Helleday, Sean G. Rudd
Publikováno v:
Molecular Oncology, Vol 16, Iss 21, Pp 3792-3810 (2022)
The exploitation of the DNA damage response and DNA repair proficiency of cancer cells is an important anticancer strategy. The replication and repair of DNA are dependent upon the supply of deoxynucleoside triphosphate (dNTP) building blocks, which
Externí odkaz:
https://doaj.org/article/34eb11aac058474dbfa1c1a3d29fe6b5
Autor:
Wenjuan Wang, Anthony G. Rudd, Yanzhong Wang, Vasa Curcin, Charles D. Wolfe, Niels Peek, Benjamin Bray
Publikováno v:
BMC Neurology, Vol 22, Iss 1, Pp 1-9 (2022)
Abstract Backgrounds We aimed to develop and validate machine learning (ML) models for 30-day stroke mortality for mortality risk stratification and as benchmarking models for quality improvement in stroke care. Methods Data from the UK Sentinel Stro
Externí odkaz:
https://doaj.org/article/231bca87b111469bbe4b551cf2fa44a1
Autor:
Sophia Ceder, Sofi E. Eriksson, Ying Yu Liang, Emarndeena H. Cheteh, Si Min Zhang, Kenji M. Fujihara, Julie Bianchi, Vladimir J. N. Bykov, Lars Abrahmsen, Nicholas J. Clemons, Pär Nordlund, Sean G. Rudd, Klas G. Wiman
Publikováno v:
Cell Death and Disease, Vol 12, Iss 7, Pp 1-10 (2021)
Abstract Asparaginase depletes extracellular asparagine in the blood and is an important treatment for acute lymphoblastic leukemia (ALL) due to asparagine auxotrophy of ALL blasts. Unfortunately, resistance occurs and has been linked to expression o
Externí odkaz:
https://doaj.org/article/b2b5eed6ca834936815c57813c137b8e
Publikováno v:
BMC Research Notes, Vol 14, Iss 1, Pp 1-6 (2021)
Abstract Objective Combinations of pharmacological agents are essential for disease control and prevention, offering many advantages over monotherapies, with one of these being drug synergy. The state-of-the-art method to profile drug synergy in prec
Externí odkaz:
https://doaj.org/article/e0ae6a05c69c43e795bb20816a3be102
Autor:
Sean G Rudd, Nikolaos Tsesmetzis, Kumar Sanjiv, Cynthia BJ Paulin, Lakshmi Sandhow, Juliane Kutzner, Ida Hed Myrberg, Sarah S Bunten, Hanna Axelsson, Si Min Zhang, Azita Rasti, Petri Mäkelä, Si'Ana A Coggins, Sijia Tao, Sharda Suman, Rui M Branca, Georgios Mermelekas, Elisée Wiita, Sun Lee, Julian Walfridsson, Raymond F Schinazi, Baek Kim, Janne Lehtiö, Georgios Z Rassidakis, Katja Pokrovskaja Tamm, Ulrika Warpman‐Berglund, Mats Heyman, Dan Grandér, Sören Lehmann, Thomas Lundbäck, Hong Qian, Jan‐Inge Henter, Torsten Schaller, Thomas Helleday, Nikolas Herold
Publikováno v:
EMBO Molecular Medicine, Vol 12, Iss 3, Pp 1-20 (2020)
Abstract The deoxycytidine analogue cytarabine (ara‐C) remains the backbone treatment of acute myeloid leukaemia (AML) as well as other haematological and lymphoid malignancies, but must be combined with other chemotherapeutics to achieve cure. Yet
Externí odkaz:
https://doaj.org/article/ee94cd1a0d794c99b66c9335300d2f1e
Publikováno v:
PeerJ, Vol 10, p e13141 (2022)
Objective The survival and clinicopathological significance of desmoglein 2 (DSG2) in various cancers is controversial. Thus, we performed this systematic review and meta-analysis to explore the preliminary prognostic value of DSG2. Methods Eligible
Externí odkaz:
https://doaj.org/article/5f05ff14158e45748c4273fa07e6ea64
Autor:
Wenjuan Wang, Anthony G. Rudd, Yanzhong Wang, Vasa Curcin, Charles D. Wolfe, Niels Peek, Benjamin Bray
Publikováno v:
BMC Neurology, Vol 22, Iss 1, Pp 1-2 (2022)
Externí odkaz:
https://doaj.org/article/0cb84bcb704945bc9b32ac82c3550d91
Autor:
Sophia Ceder, Sofi E. Eriksson, Ying Yu Liang, Emarndeena H. Cheteh, Si Min Zhang, Kenji M. Fujihara, Julie Bianchi, Vladimir J. N. Bykov, Lars Abrahmsen, Nicholas J. Clemons, Pär Nordlund, Sean G. Rudd, Klas G. Wiman
Publikováno v:
Cell Death and Disease, Vol 13, Iss 8, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/7a30218a8b2c440c80e8a3b947cee01f