Zobrazeno 1 - 10
of 77
pro vyhledávání: '"A. G. Pittman"'
Autor:
Aditi Dave, Lucy Joshee, Delon W. Barfuss, Ryan Brownlee, Roha Surani, Sahar Anis Ali, Earl G. Ford IV, Elizabeth G. Pittman, Anasalea V.G. Caroland, Jennifer Barkin, Christy C. Bridges
Publikováno v:
Current Research in Toxicology, Vol 5, Iss , Pp 100132- (2023)
Mercury (Hg) is an important environmental toxicant to which humans are exposed on a regular basis. Mercuric ions within biological systems do not exist as free ions. Rather, they are bound to free sulfhydryl groups (thiols) on biological molecules.
Externí odkaz:
https://doaj.org/article/fbbe915c408f4a8e8069484f665e44f8
Autor:
Celina A. Suarez, Joseph Frederickson, Richard L. Cifelli, Jeffrey G. Pittman, Randall L. Nydam, ReBecca K. Hunt-Foster, Kirsty Morgan
Publikováno v:
PeerJ, Vol 9, p e12242 (2021)
We present a previously discovered but undescribed late Early Cretaceous vertebrate fauna from the Holly Creek Formation of the Trinity Group in Arkansas. The site from the ancient Gulf Coast is dominated by semi-aquatic forms and preserves a diverse
Externí odkaz:
https://doaj.org/article/8cc4346abe884ffdacf8d9c8f616b36d
Autor:
Peter D. Senter, Robert P. Lyon, Weiping Zeng, Margo C. Zaval, Abbie Wong, Andrew B. Waight, Michelle L. Ulrich, Jessica K. Simmons, Paul G. Pittman, Jay C. Nix, Jason Neale, David W. Meyer, Luke V. Loftus, Fu Li, Steven Jin, Julia H. Cochran, Martha E. Anderson, Kathleen C. Olivas, Christopher S. Neumann
Supplemental tables and figures referenced in main text: Table S1 - Crystallography data collection and refinement statistics; Table S2 - ADC characterization data; Figure S1 - ADC plasma stability data; Figure S2 - Time course for ADC activity in vi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3db82a176dff235f814043a7bfa28d04
https://doi.org/10.1158/1535-7163.22505812
https://doi.org/10.1158/1535-7163.22505812
Autor:
Peter D. Senter, Robert P. Lyon, Weiping Zeng, Margo C. Zaval, Abbie Wong, Andrew B. Waight, Michelle L. Ulrich, Jessica K. Simmons, Paul G. Pittman, Jay C. Nix, Jason Neale, David W. Meyer, Luke V. Loftus, Fu Li, Steven Jin, Julia H. Cochran, Martha E. Anderson, Kathleen C. Olivas, Christopher S. Neumann
Detailed methods for ADC analytics and chemical sysnthesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::916122efb9c585694b4a5165b3263a57
https://doi.org/10.1158/1535-7163.22505815
https://doi.org/10.1158/1535-7163.22505815
Autor:
Peter D. Senter, Robert P. Lyon, Weiping Zeng, Margo C. Zaval, Abbie Wong, Andrew B. Waight, Michelle L. Ulrich, Jessica K. Simmons, Paul G. Pittman, Jay C. Nix, Jason Neale, David W. Meyer, Luke V. Loftus, Fu Li, Steven Jin, Julia H. Cochran, Martha E. Anderson, Kathleen C. Olivas, Christopher S. Neumann
Antibody–drug conjugates (ADCs) are a therapeutic modality that enables the targeted delivery of cytotoxic drugs to cancer cells. Identification of active payloads with unique mechanisms of action is a key aim of research efforts in the field. Here
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::573a206071ce06934ff2470390402a2e
https://doi.org/10.1158/1535-7163.c.6538195.v1
https://doi.org/10.1158/1535-7163.c.6538195.v1
Publikováno v:
Journal of Plant Breeding and Crop Science. 12:200-218
The practices of using isolation and distance in the seed production of open pollinated crops are fundamental concepts to ensure seed purity. We uniquely examined the effectiveness of replacing isolation plots for seed production and grass breeding w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eb7d7f4db7ffea74c9fe7ca9b8dd71ea
https://doi.org/10.5897/jpbcs2020.0893
https://doi.org/10.5897/jpbcs2020.0893
Autor:
Jeffrey G Pittman, Joseph A. Frederickson, ReBecca Hunt-Foster, Celina A. Suarez, Richard L. Cifelli, Randall L. Nydam, Kirsty Morgan
Publikováno v:
PeerJ, Vol 9, p e12242 (2021)
PeerJ
PeerJ
We present a previously discovered but undescribed late Early Cretaceous vertebrate fauna from the Holly Creek Formation of the Trinity Group in Arkansas. The site from the ancient Gulf Coast is dominated by semi-aquatic forms and preserves a diverse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72b8e17acd4f32f736966b7e7262b629
https://doi.org/10.7717/peerj.12242
https://doi.org/10.7717/peerj.12242
Publikováno v:
Toxicology and applied pharmacology. 392
Recently, we described a family of non-targeting monomethylauristatin E (MMAE) antibody-drug conjugates (ADCs) whose pharmacokinetics could be tuned through incorporation of a short polyethylene glycol (PEG) moiety of up to twelve units into a drug-l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93ff4614f90a499b3f706a5495881cce
https://pubmed.ncbi.nlm.nih.gov/32109510
https://pubmed.ncbi.nlm.nih.gov/32109510
Autor:
Julia H. Cochran, Paul G. Pittman, Steven Jin, Robert P. Lyon, Michelle Ulrich, Martha Anderson, Fu Li, Abbie Wong, Luke V. Loftus, Margo Zaval, Jay C. Nix, Jason Neale, Peter D. Senter, David W. Meyer, Jessica K. Simmons, Weiping Zeng, Andrew B. Waight, Christopher Scott Neumann, Kathleen C. Olivas
Publikováno v:
Molecular cancer therapeutics. 17(12)
Antibody–drug conjugates (ADCs) are a therapeutic modality that enables the targeted delivery of cytotoxic drugs to cancer cells. Identification of active payloads with unique mechanisms of action is a key aim of research efforts in the field. Here
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc3e4e7f3cada75f5ac91f4c7c022d8a
https://pubmed.ncbi.nlm.nih.gov/30242091
https://pubmed.ncbi.nlm.nih.gov/30242091
Autor:
Michelle Ulrich, Steven Jin, Jessica K. Simmons, Fu Li, Robert P. Lyon, Abbie Wong, Weiping Zeng, Julia H. Cochran, Kung Pern Wang, Andrew B. Waight, Paul G. Pittman, David W. Meyer, Chris Neumann, Martha Anderson, Margo Zaval, Peter D. Senter, Kathleen C. Olivas, Luke V. Loftus
Publikováno v:
Cancer Research. 79:983-983
Nicotinamide phosphoribosyltransferase (NAMPT) regulates the biosynthesis of NAD from nicotinamide via a salvage biosynthetic pathway. Inhibition of NAMPT depletes cellular NAD levels leading to disruption of energy metabolism and cell death. Non-tar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4619283e04f0c23f9c6b7da4df33e659
https://doi.org/10.1158/1538-7445.am2019-983
https://doi.org/10.1158/1538-7445.am2019-983