Zobrazeno 1 - 10
of 16
pro vyhledávání: '"A. G. P. Schuller"'
Autor:
Yun Ning, Bao Hoang, John E. Pintar, Ming-Sing Hsu, Tara P. Cominski, Alwin G. P. Schuller, Teresa L. Wood
Publikováno v:
Endocrinology. 148:2138-2147
IGFs (IGF-I and IGF-II) are essential for development, and their bioactivities are tightly regulated by six related IGF-binding proteins (IGFBPs). IGFBP-5 is the most highly conserved binding protein and is expressed in several key developmental line
Autor:
Gavril W. Pasternak, Michael A. King, Alwin G. P. Schuller, Joshua F. Nitsche, John E. Pintar, Min Zengh
Publikováno v:
The Journal of Neuroscience. 22:10906-10913
Previous experiments have shown that mice lacking a functional delta-opioid receptor (DOR-1) gene do not develop analgesic tolerance to morphine. Here we report that mice lacking a functional gene for the endogenous ligand preproenkephalin (ppENK) sh
Autor:
Sheri Bradshaw, John E. Pintar, Ellen C. Zwarthoff, Alwin G. P. Schuller, J.W. van Neck, C Groffen, Dicky J. Lindenbergh-Kortleve, Stenvert L. S. Drop, Natasja Dits, M. Van Kleffens
Publikováno v:
Endocrinology. 140:5944-5952
The insulin-like growth factor (IGF) system is an important regulator of fetal growth and differentiation. IGF bioavailability is modulated by IGF binding proteins (IGFBPs). We have generated six different antisera, directed to synthetic peptide frag
Autor:
Maureen S. Reidl, Michael A. King, Ellen M. Unterwald, John E. Pintar, Alwin G. P. Schuller, Joshua F. Nitsche, Robert Elde, Yanxin Zhu, Gavril W. Pasternak
Publikováno v:
Neuron. 24(1):243-252
Gene targeting was used to delete exon 2 of mouse DOR-1 , which encodes the δ opioid receptor. Essentially all 3H-[D-Pen 2 ,D-Pen 5 ]enkephalin ( 3 H-DPDPE) and 3H-[D-Ala 2 ,D-Glu 4 ]deltorphin ( 3 H-deltorphin-2) binding is absent from mutant mice,
Autor:
Alwin G. P. Schuller, Johannes A Maassen, T. Gloudemans, Klaas Hoekman, Jaap van Doorn, Herbert M. Pinedo
Publikováno v:
Clinical Endocrinology. 51:247-253
Non-islet-cell tumour-induced hypoglycaemia (NICTH) is, in most cases, attributable to tumour production of insulin-like growth factor II (IGF-II). Tumour-derived IGF-II has a higher than normal molecular weight (big 'IGF-II') and an impaired ability
Autor:
A. Flyvbjerg, C Groffen, Stenvert L. S. Drop, J W van Neck, M. Van Kleffens, A G P Schuller, Roberto R. Rosato, Dicky J. Lindenbergh-Kortleve, I Dørup
Publikováno v:
Journal of Molecular Endocrinology. 19:59-66
Dietary potassium (K) depletion is known to reduce body weight gain and organ growth, except for kidney which increases in weight. This renal hypertrophy is preceded by increased renal IGF-I levels. In the present study, we investigated IGF-I and -II
Publikováno v:
Molecular Endocrinology. 9:902-912
Insulin-like growth factor II (IGF-II)-overexpressing NIH 3T3 cells were used to examine regulation of insulin-like growth factor binding protein (IGFBP) and mannose 6-phosphate (M6P)/IGF-II receptor expression. Ligand blot analysis of conditioned me
Publikováno v:
Journal of Molecular Endocrinology, 14(3), 349-355. Bioscientifica Ltd
The IGFs are important mitogens involved in lung growth and development. The regulation of IGF action depends not only on the expression of IGFs and IGF receptors, but also on the modulation of IGF activity by IGF-binding proteins (IGFBPs). In this s
Publikováno v:
Molecular and Cellular Endocrinology, 104(1), 57-66. Elsevier Ireland Ltd
The insulin-like growth factor binding proteins (IGFBPs) comprise a family of six distinct proteins which modulate insulin-like growth factor action. We have isolated cDNAs encoding the six mouse IGFBPs (mIGFBPs). In addition, we studied the mRNA exp
Publikováno v:
Endocrinology. 132:2544-2550
The insulin-like growth factor-binding proteins (IGFBPs) comprise at least six distinct species that may modulate the action of IGFs. IGFs are important regulators of fetal growth and differentiation. To define sites of IGFBP mRNA synthesis, we have