Zobrazeno 1 - 10
of 1 234
pro vyhledávání: '"A. G. Murzin"'
Autor:
Yang Yang, Alexey G. Murzin, Sew Peak-Chew, Catarina Franco, Holly J. Garringer, Kathy L. Newell, Bernardino Ghetti, Michel Goedert, Sjors H. W. Scheres
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-11 (2023)
Abstract We used electron cryo-microscopy (cryo-EM) to determine the structures of Aβ40 filaments from the leptomeninges of individuals with Alzheimer’s disease and cerebral amyloid angiopathy. In agreement with previously reported structures, whi
Externí odkaz:
https://doaj.org/article/3b5c675531d343d79d122581505c8219
Autor:
Manuel Schweighauser, Alexey G. Murzin, Jennifer Macdonald, Isabelle Lavenir, R. Anthony Crowther, Sjors H.W. Scheres, Michel Goedert
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-11 (2023)
Abstract Mice transgenic for human mutant P301S tau are widely used as models for human tauopathies. They develop neurodegeneration and abundant filamentous inclusions made of human mutant four-repeat tau. Here we used electron cryo-microscopy (cryo-
Externí odkaz:
https://doaj.org/article/43edd87f5ecc46a6b3d9100ebbe7d73f
Autor:
Sofia Lövestam, Fujiet Adrian Koh, Bart van Knippenberg, Abhay Kotecha, Alexey G Murzin, Michel Goedert, Sjors HW Scheres
Publikováno v:
eLife, Vol 11 (2022)
Abundant filamentous inclusions of tau are characteristic of more than 20 neurodegenerative diseases that are collectively termed tauopathies. Electron cryo-microscopy (cryo-EM) structures of tau amyloid filaments from human brain revealed that disti
Externí odkaz:
https://doaj.org/article/5a43a79ce71b4064afeb8da1c61ff062
Autor:
Yang Yang, Yang Shi, Manuel Schweighauser, Xianjun Zhang, Abhay Kotecha, Alexey G. Murzin, Holly J. Garringer, Patrick W. Cullinane, Yuko Saito, Tatiana Foroud, Thomas T. Warner, Kazuko Hasegawa, Ruben Vidal, Shigeo Murayama, Tamas Revesz, Bernardino Ghetti, Masato Hasegawa, Tammaryn Lashley, Sjors H. W. Scheres, Michel Goedert
Publikováno v:
Nature. 610:791-795
Parkinson's disease (PD) is the most common movement disorder, with resting tremor, rigidity, bradykinesia and postural instability being major symptoms
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f6c4ab1f739fba5041dfa0da2356e5f
https://doi.org/10.1038/s41586-022-05319-3
https://doi.org/10.1038/s41586-022-05319-3
Autor:
Wenjuan Zhang, Benjamin Falcon, Alexey G Murzin, Juan Fan, R Anthony Crowther, Michel Goedert, Sjors HW Scheres
Publikováno v:
eLife, Vol 8 (2019)
Assembly of microtubule-associated protein tau into filamentous inclusions underlies a range of neurodegenerative diseases. Tau filaments adopt different conformations in Alzheimer’s and Pick’s diseases. Here, we used cryo- and immuno- electron m
Externí odkaz:
https://doaj.org/article/ee4f6398c129456c86cb564b7b6c494a
Autor:
Chao Qi, Bert M. Verheijen, Yasumasa Kokubo, Yang Shi, Stephan Tetter, Alexey G. Murzin, Asa Nakahara, Satoru Morimoto, Marc Vermulst, Ryogen Sasaki, Eleonora Aronica, Yoshifumi Hirokawa, Kiyomitsu Oyanagi, Akiyoshi Kakita, Benjamin Ryskeldi-Falcon, Mari Yoshida, Masato Hasegawa, Sjors H.W. Scheres, Michel Goedert
The amyotrophic lateral sclerosis/parkinsonism-dementia complex (ALS/PDC) of the island of Guam and the Kii peninsula of Japan is a fatal neurodegenerative disease of unknown cause that is characterised by the presence of abundant filamentous tau inc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0f779473c64a84946a11bd70fba7e3ee
https://doi.org/10.1101/2023.04.26.538417
https://doi.org/10.1101/2023.04.26.538417
Autor:
Manuel Schweighauser, Diana Arseni, Mehtap Bacioglu, Melissa Huang, Sofia Lövestam, Yang Shi, Yang Yang, Wenjuan Zhang, Abhay Kotecha, Holly J. Garringer, Ruben Vidal, Grace I. Hallinan, Kathy L. Newell, Airi Tarutani, Shigeo Murayama, Masayuki Miyazaki, Yuko Saito, Mari Yoshida, Kazuko Hasegawa, Tammaryn Lashley, Tamas Revesz, Gabor G. Kovacs, John van Swieten, Masaki Takao, Masato Hasegawa, Bernardino Ghetti, Maria Grazia Spillantini, Benjamin Ryskeldi-Falcon, Alexey G. Murzin, Michel Goedert, Sjors H. W. Scheres
Publikováno v:
Nature, 605(7909), 310-314. Nature Publishing Group
Many age-dependent neurodegenerative diseases, such as Alzheimer’s and Parkinson’s, are characterized by abundant inclusions of amyloid filaments. Filamentous inclusions of the proteins tau, amyloid-β, α-synuclein and transactive response DNA-b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ded8584e1f06a89d4adb15b9b46d57c
https://pure.eur.nl/en/publications/11fb046e-f3ec-4d89-b0e9-695ac325b3cc
https://pure.eur.nl/en/publications/11fb046e-f3ec-4d89-b0e9-695ac325b3cc
Autor:
Yang Yang, Holly J. Garringer, Yang Shi, Sofia Lövestam, Xianjun Zhang, Abhay Kotecha, Mehtap Bacioglu, Atsuo Koto, Masaki Takao, Maria Grazia Spillantini, Bernardino Ghetti, Ruben Vidal, Alexey G. Murzin, Sjors H.W. Scheres, Michel Goedert
A 21-nucleotide duplication in one allele ofSNCAwas identified in a previously described disease with abundant α-synuclein inclusions that we now call juvenile-onset synucleinopathy (JOS). Both wild-type α-synuclein and its insertion mutant contain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::97437b50a8f2f6a9050d9108dde5e1eb
https://doi.org/10.1101/2022.11.23.517690
https://doi.org/10.1101/2022.11.23.517690
Autor:
Yang Yang, Wenjuan Zhang, Alexey G. Murzin, Manuel Schweighauser, Melissa Huang, Sofia Lövestam, Sew Y. Peak-Chew, Takashi Saito, Takaomi C. Saido, Jennifer Macdonald, Isabelle Lavenir, Bernardino Ghetti, Caroline Graff, Amit Kumar, Agneta Nordberg, Michel Goedert, Sjors H. W. Scheres
Publikováno v:
Acta neuropathologica.
Funder: Biotechnology and Biological Sciences Research Council; doi: http://dx.doi.org/10.13039/501100000268
The Arctic mutation, encoding E693G in the amyloid precursor protein (APP) gene [E22G in amyloid-β (Aβ)], causes dominantly inherited
The Arctic mutation, encoding E693G in the amyloid precursor protein (APP) gene [E22G in amyloid-β (Aβ)], causes dominantly inherited
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::084ff36d086a4dcbffb5d0983f871c89
https://pubmed.ncbi.nlm.nih.gov/36611124
https://pubmed.ncbi.nlm.nih.gov/36611124
Autor:
Fuyuki Kametani, Ruben Vidal, Mike van Beers, Abhay Kotecha, H. Tanaka, Airi Tarutani, Tammaryn Lashley, Wenjuan Zhang, Yang Yang, Yang Shi, Benjamin Falcon, Takeshi Ikeuchi, Michel Goedert, Sjors H.W. Scheres, Holly J. Garringer, Bernardino Ghetti, Gabor G. Kovacs, Mari Yoshida, Masato Hasegawa, Akiyoshi Kakita, Alexey G. Murzin, Andrew C Robinson, David M. A. Mann, Tamas Revesz, Yuko Saito, G.I. Hallinan, Shigeo Murayama
Publikováno v:
Nature
Shi, Y, Zhang, W, Yang, Y, Murzin, A G, Falcon, B, Kotecha, A, van Beers, M, Tarutani, A, Kametani, F, Garringer, H J, Vidal, R, Hallinan, G I, Lashley, T, Saito, Y, Murayama, S, Yoshida, M, Tanaka, H, Kakita, A, Ikeuchi, T, Robinson, A C, Mann, D M A, Kovacs, G G, Revesz, T, Ghetti, B, Hasegawa, M, Goedert, M & Scheres, S H W 2021, ' Structure-based classification of tauopathies ', Nature, vol. 598, no. 7880, pp. 359-363 . https://doi.org/10.1038/s41586-021-03911-7
Shi, Y, Zhang, W, Yang, Y, Murzin, A G, Falcon, B, Kotecha, A, van Beers, M, Tarutani, A, Kametani, F, Garringer, H J, Vidal, R, Hallinan, G I, Lashley, T, Saito, Y, Murayama, S, Yoshida, M, Tanaka, H, Kakita, A, Ikeuchi, T, Robinson, A C, Mann, D M A, Kovacs, G G, Revesz, T, Ghetti, B, Hasegawa, M, Goedert, M & Scheres, S H W 2021, ' Structure-based classification of tauopathies ', Nature, vol. 598, no. 7880, pp. 359-363 . https://doi.org/10.1038/s41586-021-03911-7
Ordered assembly of the tau protein into filaments characterizes multiple neurodegenerative diseases, which are called tauopathies. We previously reported that by electron cryo-microscopy (cryo-EM), tau filament structures from Alzheimer’s disease
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df46db44639458e3f071db56fadf1871
https://doi.org/10.1038/s41586-021-03911-7
https://doi.org/10.1038/s41586-021-03911-7