Phase I study of gene-mediated cytotoxic immunotherapy with AdV-tk as adjuvant to surgery and radiation for pediatric malignant glioma and recurrent ependymoma

Autor: Liliana Goumnerova, Stewart Goldman, Rishi Lulla, Estuardo Aguilar-Cordova, Susan N. Chi, Peter E. Manley, Andrea G. Manzanera, Mark W. Kieran, Tadanori Tomita, Karen J. Marcus, Laura K. Aguilar, Arthur J DiPatri

Publikováno v: Neuro-Oncology. 21:537-546

Background Gene-mediated cytotoxic immunotherapy (GMCI) is a tumor-specific immune stimulatory strategy implemented through local delivery of aglatimagene besadenovec (AdV-tk) followed by anti-herpetic prodrug. GMCI induces T-cell dependent tumor imm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f0eb64f64c50a164d5c836477183038
https://doi.org/10.1093/neuonc/noy202

CTIM-13. PHASE 1 CLINICAL TRIAL OF ONCOLYTIC VIRAL IMMUNOTHERAPY WITH CAN-2409 + VALACYCLOVIR IN COMBINATION WITH NIVOLUMAB AND STANDARD OF CARE (SOC) IN NEWLY DIAGNOSED HIGH-GRADE GLIOMA (HGG)

Autor: Estuardo Aguilar-Cordova, Serena Desideri, Pierpaolo Peruzzi, Patrick Y. Wen, Wenya Linda Bi, Frank S. Lieberman, Ian Lee, James Snyder, Steven Brem, Paul Peter Tak, Sean E. Lawler, Susan Bell, Stephen J Bagley, Nirav J. Patel, Andrea G. Manzanera, E. Antonio Chiocca, Francesca Barone, Nduka Amankulor, Lenika Lopez, L. Burt Nabors, Megan Mantica, Neeraja Danda, Brian W. Guzik, Stephen B. Tatter, Stuart A. Grossman, Tobias Walbert, Laura K. Aguilar, Roy E. Strowd, Lixian Jin, Arati Desai, William Timmer, Xiaobu Ye, David A. Reardon

Publikováno v: Neuro-Oncology. 23:vi52-vi52

BACKGROUND CAN-2409 is a replication-deficient adenovirus that delivers HSV thymidine kinase to cancer cells, resulting in local conversion of orally administered valacyclovir into a toxic metabolite. Previously, a phase 1b/2 clinical trial of CAN-24

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::878ef996c3d5f0cfe21fd7134a1d39b1
https://doi.org/10.1093/neuonc/noab196.205

Phase I Study of Intrapleural Gene-Mediated Cytotoxic Immunotherapy in Patients with Malignant Pleural Effusion

Autor: Tracey L. Evans, Andrew R. Haas, Sharyn I. Katz, Joshua Bauml, Steven M. Albelda, Daniel H. Sterman, Gregoria Gómez-Hernández, Charu Aggarwal, Susan Metzger, Estuardo Aguilar-Cordova, Andrea G. Manzanera, Roger B. Cohen, Evan W. Alley, Corey J. Langer, Laura K. Aguilar

Publikováno v: Molecular therapy : the journal of the American Society of Gene Therapy. 26(5)

Gene-mediated cytotoxic immunotherapy (GMCI) is an immune strategy implemented through local delivery of an adenovirus-based vector expressing the thymidine kinase gene (aglatimagene besadenovec, AdV-tk) followed by anti-herpetic prodrug valacyclovir

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::624af764939dcf95a6ae383a87774921
https://pubmed.ncbi.nlm.nih.gov/29550074

IMMUNOTHERAPY

Autor: M. J. Hickey, C. K. Malone, K. L. Erickson, L. E. Gerschenson, A. H. Lin, A. Inagaki, K. Hiraoka, N. Kasahara, B. Mueller, C. A. Kruse, S. Kong, B. Tyler, J. Zhou, B. S. Carter, H. Brem, R. P. Junghans, P. Sampath, R. K. Lai, L. D. Recht, D. A. Reardon, N. Paleologos, M. Groves, M. R. Rosenfeld, T. Davis, J. Green, A. Heimberger, J. Sampson, N. Hashimoto, A. Tsuboi, Y. Chiba, N. Kijima, Y. Oka, M. Kinoshita, N. Kagawa, Y. Fujimoto, H. Sugiyama, T. Yoshimine, S. M. Birks, M. Burnet, G. J. Pilkington, J. S. Yu, C. J. Wheeler, J. Rudnick, M. Mazer, H. Q. Wang, M. A. Nuno, J. E. Richardson, X. Fan, J. Ji, R. M. Chu, J. G. Bender, E. W. Hawkins, K. L. Black, S. Phuphanich, I. F. Pollack, R. I. Jakacki, L. H. Butterfield, H. Okada, M. A. Hunt, G. E. Pluhar, B. M. Andersen, J. L. Gallardo, C. O. Seiler, K. S. SantaCruz, J. R. Ohlfest, D. F. Bauer, L. S. Lamb, D. K. Harmon, X. Zheng, A. K. Romeo, G. Y. Gillespie, J. N. Parker, J. M. Markert, V. L. Jacobs, R. P. Landry, J. A. De Leo, J. E. Bromberg, J. Doorduijn, J. W. Baars, G. W. van Imhoff, R. Enting, M. J. van den Bent, K. A. Murphy, J. Bedi, A. Epstein, M. Olin, B. Andersen, L. Swier, J. Ohlfest, A. J. Litterman, D. M. Zellmer, E. A. Chiocca, L. K. Aguilar, E. Aguilar-Cordova, A. G. Manzanera, K. R. Harney, J. Portnow, B. Badie, M. Lesniak, S. Bell, A. Ray-Chaudhuri, B. Kaur, J. Hardcastle, R. Cavaliere, J. McGregor, S. Lo, A. Chakarvarti, J. Grecula, H. Newton, T. W. Trask, D. S. Baskin, P. Z. New, J. Zeng, A. P. See, J. Phallen, Z. Belcaid, N. Durham, C. Meyer, E. Albesiano, G. Pradilla, E. Ford, H. Hammers, P. T. Tran, D. Pardoll, C. G. Drake, M. Lim, A. Ghazi, A. Ashoori, P. Hanley, V. Salsman, D. R. Schaffer, Z. Grada, Y. Kew, S. Z. Powell, R. Grossman, M. E. Scheurer, A. M. Leen, C. M. Rooney, C. M. Bollard, H. E. Heslop, S. Gottschalk, N. Ahmed, J. Hu, C. Patil, M. Nuno, C. Wheeler, R. Chu, K. Black, J. Yu, A. Marabelle, H. Kohrt, J. Brody, R. Luong, V. Tse, R. Levy, Y. M. Li, H. Jun, M. Shahryar, V. A. Daniel, H. A. Walter, I. Thaipisuttikul, E. Avila, D. A. Mitchell, G. E. Archer, H. S. Friedman, J. E. Herndon, D. D. Bigner, J. H. Sampson, L. A. Johnson, S. K. Nair, R. Schmittling, E. Reap, J. P. Knisely, H. Kluger, J. Flanigan, M. Sznol, J. B. Yu, V. L. Chiang, R. M. Prins, W. Kim, H. Soto, D. N. Lisiero, L. M. Liau

Publikováno v: Neuro-Oncology. 13:iii34-iii40

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74cba0dafd93fb4746c77236184bf170
https://doi.org/10.1093/neuonc/nor151

Tratamiento quirúrgico del cáncer de vulva: vulvectomía radical frente a vulvectomía radical modificada

Autor: C. Salvador Ballada, G. Manzanera Bueno, A. Alejos Monzón, M.J. Iñarra Velasco, E. Esteban Campeny

Publikováno v: Progresos de Obstetricia y Ginecología. 45:238-244

Resumen Objetivo Valorar las complicaciones postoperatorias tempranas y tardias segun la tecnica quirurgica en el tratamiento del cancer vulvar asi como las recurrencias y la supervivencia Sujetos y metodos Se estudian 44 casos de cancer vulvar habid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4dea02ec78fa17f6de69153ca20bd0cc
https://doi.org/10.1016/s0304-5013(02)75770-1