Zobrazeno 1 - 10
of 4 346
pro vyhledávání: '"A. G. M. Barrett"'
Autor:
Victoria I. Cushing, Adrian F. Koh, Junjie Feng, Kaste Jurgaityte, Alexander Bondke, Sebastian H. B. Kroll, Marion Barbazanges, Bodo Scheiper, Ash K. Bahl, Anthony G. M. Barrett, Simak Ali, Abhay Kotecha, Basil J. Greber
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Rational design of next-generation therapeutics can be facilitated by high-resolution structures of drug targets bound to small-molecule inhibitors. However, application of structure-based methods to macromolecules refractory to crystallizat
Externí odkaz:
https://doaj.org/article/a393bf7c13c14f7a93881e19f56dabfa
Autor:
Christian Winter, Isabella Siepe, Andrew Wise, Alain Dorali, Anthony G. M. Barrett, Matthias Witschel
Publikováno v:
ACS Medicinal Chemistry Letters. 14:136-140
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fa225fd54475d98a9f380b07e93a3184
https://doi.org/10.1021/acsmedchemlett.2c00497
https://doi.org/10.1021/acsmedchemlett.2c00497
Autor:
Joshua Almond-Thynne, Andrew J. P. White, Anastasios Polyzos, Henry S. Rzepa, Philip J. Parsons, Anthony G. M. Barrett
Publikováno v:
ACS Omega, Vol 2, Iss 7, Pp 3241-3249 (2017)
Externí odkaz:
https://doaj.org/article/52b451cb7f8d4a2c9fe38ec5d338c4a0
Autor:
Simak Ali, R. Charles Coombes, Anthony G. M. Barrett, Matthew J. Fuchter, Laki Buluwela, Eric O. Aboagye, Alison Harrod, Silvia Ottaviani, Richard Starkey, Marion Barbazanges, Sebastian H. B. Kroll, Brian W. Slafer, Alexander Bondke, Georgina P. Sava, Manikandan Periyasamy, Hetal Patel
In vitro kinase assays demonstrate selectivity of ICEC0942 for CDK7.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3115379f20023b58b11b5bd3f114b3e9
https://doi.org/10.1158/1535-7163.22505256.v1
https://doi.org/10.1158/1535-7163.22505256.v1
Autor:
Simak Ali, R. Charles Coombes, Anthony G. M. Barrett, Matthew J. Fuchter, Laki Buluwela, Eric O. Aboagye, Alison Harrod, Silvia Ottaviani, Richard Starkey, Marion Barbazanges, Sebastian H. B. Kroll, Brian W. Slafer, Alexander Bondke, Georgina P. Sava, Manikandan Periyasamy, Hetal Patel
Recent reports indicate that some cancer types are especially sensitive to transcription inhibition, suggesting that targeting the transcriptional machinery provides new approaches to cancer treatment. Cyclin-dependent kinase (CDK)7 is necessary for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7954b2e0f9b8731f18d462f3b2edad27
https://doi.org/10.1158/1535-7163.c.6537999.v1
https://doi.org/10.1158/1535-7163.c.6537999.v1
Autor:
Simak Ali, R. Charles Coombes, Anthony G. M. Barrett, Matthew J. Fuchter, Laki Buluwela, Eric O. Aboagye, Alison Harrod, Silvia Ottaviani, Richard Starkey, Marion Barbazanges, Sebastian H. B. Kroll, Brian W. Slafer, Alexander Bondke, Georgina P. Sava, Manikandan Periyasamy, Hetal Patel
Figure legends for supplementary Figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29e68a2e65994bf8e6171e2a36349138
https://doi.org/10.1158/1535-7163.22505235
https://doi.org/10.1158/1535-7163.22505235
Autor:
Thomas Mies, Christian Schürmann, Sho Ito, Andrew J. P. White, Mark R. Crimmin, Anthony G. M. Barrett
Publikováno v:
Zeitschrift für anorganische und allgemeine Chemie. 649
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4c4bf55079317c32bbe4ee2a3b677032
https://doi.org/10.1002/zaac.202300027
https://doi.org/10.1002/zaac.202300027
Autor:
Thomas Mies, Christian Schürmann, Sho Ito, Andrew J. P. White, Mark R. Crimmin, Anthony G. M. Barrett
Publikováno v:
Zeitschrift für anorganische und allgemeine Chemie. 649
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4db1b170ee6ce3a7b7d9b6e66725df26
https://doi.org/10.1002/zaac.202200294
https://doi.org/10.1002/zaac.202200294
Publikováno v:
ACS Med Chem Lett
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7525cc72f2b4e398526956eb98264a0
https://doi.org/10.1021/acsmedchemlett.1c00413
https://doi.org/10.1021/acsmedchemlett.1c00413
Autor:
Thomas Mies, Christian Schürmann, Sho Ito, Andrew J. P. White, Mark R. Crimmin, Anthony G. M. Barrett
The synthesis and characterisation of a calcium pyrazolonato complex is reported. X-Ray diffraction (XRD) of single crystals revealed an octahedral geometry with two axial solvent ligands. Analysis of the bulk sample by means of microcrystal electron
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6223e5ed7ed51815d422fd849d8ca05d
https://doi.org/10.26434/chemrxiv-2022-q51s2
https://doi.org/10.26434/chemrxiv-2022-q51s2