Zobrazeno 1 - 10
of 34
pro vyhledávání: '"A. G. Lyakhov"'
Autor:
E. A. Bel'skii, A. G. Lyakhov
Publikováno v:
Russian Journal of Ecology. 52:296-306
The dynamics of the species richness, breeding density, and structure of the community of birds occupying nest-boxes upon a 50-fold reduction of atmospheric emissions from the Middle Ural Copper Smelter was analyzed based on long-term continuous obse
Publikováno v:
Russian Journal of Ecology. 51:294-298
Publikováno v:
Russian Journal of Ecology. 48:256-261
Variability of the length of the white area on the outermost quill feathers of the great tit from two cities in the Middle Ural has been investigated. Dynamics of the average length of the white area in the birds from the city of Asbest reproduced th
Autor:
Rafal Zielinski, Amir H. Gandjbakhche, Kimberly Shafer-Weaver, Monika Kuban, Jacek Capala, Moinuddin Hassan, Ilya G. Lyakhov
Publikováno v:
Clinical Cancer Research. 17:5071-5081
Purpose: Cancers overexpressing the HER2/neu gene are usually more aggressive and are associated with poor prognosis. Although trastuzumab has significantly improved the outcome, many tumors do not respond or acquire resistance to current therapies.
Autor:
Ilya G. Lyakhov, Jacek Capala, Brandon T. Smith, Anu Puri, Kristin H. Loomis, Danielle Needle, Ulrich Baxa, Amichai Yavlovich, Robert Blumenthal
Publikováno v:
Journal of Controlled Release. 153:187-194
We previously reported the formulation and physical properties of HER2 (human epidermal growth factor receptor 2)-specific affibody (ZHER2:342-Cys) conjugated thermosensitive liposomes (HER2(+)affisomes). Here we examined localized delivery potential
Autor:
Rafal Zielinski, Monika Kuban, Ilya G. Lyakhov, Jacek Capala, Moinuddin Hassan, K Shafer-Weaver
Publikováno v:
Cancer Research. 70:P3-14
Introduction: Cancers overexpressing HER2 gene are usually described as more aggressive and are associated with poor prognosis. Although introduction of trastuzumab, a HER2-specific humanized antibody, significantly improved the outcome, there are st
Autor:
Oleg Chertov, Gabriela Kramer-Marek, Jacek Capala, Ilya G. Lyakhov, Monika Kuban, Rafal Zielinski, Lakshman Bindu, Robert J. Fisher
Publikováno v:
ChemBioChem. 11:345-350
The human epidermal growth factor receptors, EGFR and HER2, are members of the EGFR family of cell-surface receptors/tyrosine kinases. EGFR- and HER2-positive cancers represent a more aggressive disease with greater likelihood of recurrence, poorer p
Autor:
Rafal Zielinski, Gabriela Kramer-Marek, Oleg Chertov, Robert Blumenthal, Andrew G. Stephen, Ilya G. Lyakhov, Amy Jacobs, Jacek Capala, Robert J. Fisher, Nicholas Francella
Publikováno v:
Journal of Immunotherapy. 32:817-825
Expression of the human epidermal growth factor receptor 2 (HER2) is amplified in 25 – 30% of breast cancers and has been associated with an unfavorable prognosis. Here we report the construction, purification, and characterization of Affitoxin –
Autor:
Zehua Chen, Ilya G. Lyakhov, Ryan K. Shultzaberger, Karen A. Lewis, Ming Zheng, Bernard Doan, Gisela Storz, Thomas D. Schneider
Publikováno v:
Nucleic Acids Research
Fur is a DNA binding protein that represses bacterial iron uptake systems. Eleven footprinted Escherichia coli Fur binding sites were used to create an initial information theory model of Fur binding, which was then refined by adding 13 experimentall
Autor:
Robert J. Fisher, Ilya G. Lyakhov, Igor A. Sidorov, Ryan K. Shultzaberger, Thomas D. Schneider, Lindsey R. Roberts, Andrew G. Stephen
Publikováno v:
Nucleic Acids Research
Individual protein binding sites on DNA can be measured in bits of information. This information is related to the free energy of binding by the second law of thermodynamics, but binding kinetics appear to be inaccessible from sequence information si