Sex differences in the effectiveness of first-line tumour necrosis factor inhibitors in axial spondyloarthritis: results from the EuroSpA Research Collaboration Network

Autor: Ronald F van Vollenhoven, Bente Glintborg, Merete Lund Hetland, Ulf Lindström, Brigitte Michelsen, Elsa Vieira-Sousa, Florenzo Iannone, Eirik Klami Kristianslund, Dan Nordström, Karel Pavelka, Ziga Rotar, Maria Jose Santos, Catalin Codreanu, Gary J Macfarlane, Mikkel Østergaard, Michael T Nurmohamed, Jiri Vencovsky, Rosario Foti, Bjorn Gudbjornsson, Matija Tomšič, Lykke Midtbøll Ørnbjerg, Adrian Ciurea, Árni Jón Geirsson, Irene van der Horst-Bruinsma, Michael S Nissen, Ovidiu Rotariu, Isabel Castrejón, Johan K Wallman, Marleen van de Sande, Anne G Loft, Pasoon Hellamand, Thomas Klausch, Anna Mari Hokkanen, Corina Mogosan, Lucia Otero-Varela, Semih Gulle, Berrin Zengin

Publikováno v: RMD Open, Vol 9, Iss 4 (2023)

Objective Evidence indicates reduced treatment effectiveness of TNFi in women with axial spondyloarthritis (axSpA) compared with men. We aimed to investigate sex differences in treatment response and retention rates over 24 months of follow-up in axS

Externí odkaz: https://doaj.org/article/e6632f400b4e4c9eb966b1dc4cf15287

Multiomics analysis of rheumatoid arthritis yields sequence variants that have large effects on risk of the seropositive subset

Autor: Saedis, Saevarsdottir, Lilja, Stefansdottir, Patrick, Sulem, Gudmar, Thorleifsson, Egil, Ferkingstad, Gudrun, Rutsdottir, Bente, Glintborg, Helga, Westerlind, Gerdur, Grondal, Isabella C, Loft, Signe Bek, Sorensen, Benedicte A, Lie, Mikael, Brink, Lisbeth, Ärlestig, Asgeir Orn, Arnthorsson, Eva, Baecklund, Karina, Banasik, Steffen, Bank, Lena I, Bjorkman, Torkell, Ellingsen, Christian, Erikstrup, Oleksandr, Frei, Inger, Gjertsson, Daniel F, Gudbjartsson, Sigurjon A, Gudjonsson, Gisli H, Halldorsson, Oliver, Hendricks, Jan, Hillert, Estrid, Hogdall, Søren, Jacobsen, Dorte Vendelbo, Jensen, Helgi, Jonsson, Alf, Kastbom, Ingrid, Kockum, Salome, Kristensen, Helga, Kristjansdottir, Margit H, Larsen, Asta, Linauskas, Ellen-Margrethe, Hauge, Anne G, Loft, Bjorn R, Ludviksson, Sigrun H, Lund, Thorsteinn, Markusson, Gisli, Masson, Pall, Melsted, Kristjan H S, Moore, Heidi, Munk, Kaspar R, Nielsen, Gudmundur L, Norddahl, Asmundur, Oddsson, Thorunn A, Olafsdottir, Pall I, Olason, Tomas, Olsson, Sisse Rye, Ostrowski, Kim, Hørslev-Petersen, Solvi, Rognvaldsson, Helga, Sanner, Gilad N, Silberberg, Hreinn, Stefansson, Erik, Sørensen, Inge J, Sørensen, Carl, Turesson, Thomas, Bergman, Lars, Alfredsson, Tore K, Kvien, Søren, Brunak, Kristján, Steinsson, Vibeke, Andersen, Ole A, Andreassen, Solbritt, Rantapää-Dahlqvist, Merete Lund, Hetland, Lars, Klareskog, Johan, Askling, Leonid, Padyukov, Ole Bv, Pedersen, Unnur, Thorsteinsdottir, Ingileif, Jonsdottir, Kari, Stefansson

Publikováno v: Saevarsdottir, S, Stefansdottir, L, Sulem, P, Thorleifsson, G, Ferkingstad, E, Rutsdottir, G, Glintborg, B, Westerlind, H, Grondal, G, Loft, I C, Sorensen, S B, Lie, B A, Brink, M, Ärlestig, L, Arnthorsson, A O, Baecklund, E, Banasik, K, Bank, S, Bjorkman, L I, Ellingsen, T, Erikstrup, C, Frei, O, Gjertsson, I, Gudbjartsson, D F, Gudjonsson, S A, Halldorsson, G H, Hendricks, O, Hillert, J, Hogdall, E, Jacobsen, S, Jensen, D V, Jonsson, H, Kastbom, A, Kockum, I, Kristensen, S, Kristjansdottir, H, Larsen, M H, Linauskas, A, Hauge, E-M, Loft, A G, Ludviksson, B R, Lund, S H, Ostrowski, S R, Sørensen, E, Sørensen, I J, Brunak, S, Andersen, V, Hetland, M L, Askling, J, Pedersen, O B & Members of the DBDS Genomic Consortium 2022, ' Multiomics analysis of rheumatoid arthritis yields sequence variants that have large effects on risk of the seropositive subset ', Annals of the Rheumatic Diseases, vol. 81, no. 8, pp. 1085-1095 . https://doi.org/10.1136/annrheumdis-2021-221754
Saevarsdottir, S, Stefansdottir, L, Sulem, P, Thorleifsson, G, Ferkingstad, E, Rutsdottir, G, Glintborg, B, Westerlind, H, Grondal, G, Loft, I C, Sorensen, S B, Lie, B A, Brink, M, Arlestig, L, Arnthorsson, A O, Baecklund, E, Banasik, K, Bank, S, Bjorkman, L I, Ellingsen, T, Erikstrup, C, Frei, O, Gjertsson, I, Gudbjartsson, D F, Gudjonsson, S A, Halldorsson, G H, Hendricks, O, Hillert, J, Hogdall, E, Jacobsen, S, Jensen, D V, Jonsson, H, Kastbom, A, Kockum, I, Kristensen, S, Kristjansdottir, H, Larsen, M H, Linauskas, A, Hauge, E M, Loft, A G, Ludviksson, B R, Lund, S H, Markusson, T, Masson, G, Melsted, P, Moore, K H S, Munk, H, Nielsen, K R, Norddahl, G L, Oddsson, A, DBDS Genomic Consortium, The Danish RA Genetics Working Group & The Swedish Rheumatology Quality Register Biobank Study Group (SRQb) 2022, ' Multiomics analysis of rheumatoid arthritis yields sequence variants that have large effects on risk of the seropositive subset ', Annals of the Rheumatic Diseases, vol. 81, no. 8, pp. 1085-1095 . https://doi.org/10.1136/annrheumdis-2021-221754
Annals of the Rheumatic Diseases
Saevarsdottir, S, Stefansdottir, L, Sulem, P, Thorleifsson, G, Ferkingstad, E, Rutsdottir, G, Glintborg, B, Westerlind, H, Grondal, G, Loft, I C, Sorensen, S B, Lie, B A, Brink, M, Ärlestig, L, Arnthorsson, A O, Baecklund, E, Banasik, K, Bank, S, Bjorkman, L I, Ellingsen, T, Erikstrup, C, Frei, O, Gjertsson, I, Gudbjartsson, D F, Gudjonsson, S A, Halldorsson, G H, Hendricks, O, Hillert, J, Hogdall, E, Jacobsen, S, Jensen, D V, Jonsson, H, Kastbom, A, Kockum, I, Kristensen, S, Kristjansdottir, H, Larsen, M H, Linauskas, A, Hauge, E-M, Loft, A G, Ludviksson, B R, Lund, S H, Markusson, T, Masson, G, Melsted, P, Moore, K H S, Munk, H, Nielsen, K R, Norddahl, G L, Oddsson, A, Olafsdottir, T A, Olason, P I, Olsson, T, Ostrowski, S R, Hørslev-Petersen, K, Rognvaldsson, S, Sanner, H, Silberberg, G N, Stefansson, H, Sørensen, E, Sørensen, I J, Turesson, C, Bergman, T, Alfredsson, L, Kvien, T K, Brunak, S, Steinsson, K, Andersen, V, Andreassen, O A, Rantapää-Dahlqvist, S, Hetland, M L, Klareskog, L, Askling, J, Padyukov, L, Pedersen, O B, Thorsteinsdottir, U, Jonsdottir, I, Stefansson, K, Members of the DBDS Genomic Consortium & Nyegaard, M 2022, ' Multiomics analysis of rheumatoid arthritis yields sequence variants that have large effects on risk of the seropositive subset ', Annals of the Rheumatic Diseases, vol. 81, no. 8, 221754, pp. 1085-1095 . https://doi.org/10.1136/annrheumdis-2021-221754

Objectives To find causal genes for rheumatoid arthritis (RA) and its seropositive (RF and/or ACPA positive) and seronegative subsets. Methods We performed a genome-wide association study (GWAS) of 31 313 RA cases (68% seropositive) and similar to 1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfa559b7172b3407158d15a52860ec6e
https://curis.ku.dk/portal/da/publications/multiomics-analysis-of-rheumatoid-arthritis-yields-sequence-variants-that-have-large-effects-on-risk-of-the-seropositive-subset(ac8972ce-4933-4e08-88e5-2da877e76a2b).html

OP0020 SEX DIFFERENCES IN EFFECTIVENESS OF FIRST-LINE TUMOR NECROSIS FACTOR INHIBITORS IN AXIAL SPONDYLOARTHRITIS; RESULTS FROM FIFTEEN COUNTRIES IN THE EuroSpA RESEARCH COLLABORATION NETWORK

Autor: P. Hellamand, M. G. H. Van de Sande, L. Midtbøll Ørnbjerg, T. Klausch, M. Nurmohamed, R. Van Vollenhoven, D. Nordström, A. M. Hokkanen, M. J. Santos, E. Vieira-Sousa, A. G. Loft, B. Glintborg, M. Østergaard, U. Lindström, J. K. Wallman, B. Michelsen, A. Ciurea, M. J. Nissen, C. Codreanu, C. Mogosan, G. Macfarlane, G. T. Jones, K. Laas, Z. Rotar, M. Tomsic, I. Castrejon, M. Pombo-Suarez, B. Gudbjornsson, A. J. Geirsson, E. Kristianslund, J. Vencovský, L. Nekvindova, S. Gulle, B. Zengin, M. L. Hetland, I. Van der Horst-Bruinsma

Publikováno v: Annals of the Rheumatic Diseases. 81:13-14

BackgroundEvidence reveals sex differences in physiology, disease presentation and response to treatment in axial spondyloarthritis (axSpA). Pooled data from four randomized controlled trials demonstrated reduced treatment efficacy of a tumor necrosi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::014a9715046a2f4baeb6bedcca922ff6
https://doi.org/10.1136/annrheumdis-2022-eular.2837

OP0022 DISEASE ACTIVITY-GUIDED TAPERING OF BIOLOGICS IN PATIENTS WITH INFLAMMATORY ARTHRITIS: A RANDOMISED, OPEN-LABEL, EQUIVALENCE TRIAL

Autor: L. Uhrenholt, R. Christensen, L. Dreyer, E. M. Hauge, A. Schlemmer, A. G. Loft, M. Nyhuus Bendix Rasch, H. C. Horn, K. Gade, P. C. Taylor, S. Kristensen

Publikováno v: Annals of the Rheumatic Diseases. 81:15-16

BackgroundTraditionally, biologics are maintained lifelong at standard dose in patients with inflammatory arthritis (IA) when sustained low disease activity (LDA) is reached. However, evidence of possible tapering is emerging but data on the optimal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::18463a32050fd6141430247f06975493
https://doi.org/10.1136/annrheumdis-2022-eular.1061

POS1226 CLINICAL FACTORS ASSOCIATED WITH A POSITIVE SARS-CoV-19 TEST AND WITH FREQUENT TESTING DURING THE COVID-19 PANDEMIC IN >10.000 PATIENTS WITH INFLAMMATORY RHEUMATIC DISEASES. RESULTS FROM A NATIONWIDE SURVEY FROM THE DANISH DANBIO REGISTRY

Autor: B. Glintborg, D. V. Jensen, L. Terslev, O. Hendricks, M. Østergaard, S. H. Rasmussen, M. Pfeiffer-Jensen, T. Adelsten, A. Colic, K. Danebod, M. Kildemand, A. G. Loft, H. L. Munk, J. K. Pedersen, R. Østgård, C. M. Sørensen, N. Steen Krogh, J. Nørgaard Agerbo, C. Ziegler, M. L. Hetland

Publikováno v: Annals of the Rheumatic Diseases. 81:944.2-945

BackgroundPatients with inflammatory rheumatic diseases (IRD) have used self-isolation and social distancing during the pandemic to avoid SARS-CoV-19 infection (reference). In countries with unlimited and free access to SARS-CoV-19 testing, anxiety o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8899717b61451a2f65ffa60b91274e34
https://doi.org/10.1136/annrheumdis-2022-eular.2234