Zobrazeno 1 - 10
of 290
pro vyhledávání: '"A. G. KANTHASAMY"'
Autor:
Zainab Riaz, Gabriel S. Richardson, Huajun Jin, Gary Zenitsky, Vellareddy Anantharam, Arthi Kanthasamy, Anumantha G. Kanthasamy
Publikováno v:
Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-21 (2024)
Abstract Nuclear pore complexes (NPCs) are embedded in the nuclear envelope and facilitate the exchange of macromolecules between the nucleus and cytoplasm in eukaryotic cells. The dysfunction of the NPC and nuclear transport plays a significant role
Externí odkaz:
https://doaj.org/article/7404e80dab15468592078e5c8aa13a56
Autor:
Emir Malovic, Alyssa Ealy, Cameron Miller, Ahyoung Jang, Phillip J. Hsu, Souvarish Sarkar, Dharmin Rokad, Cody Goeser, Aleah Kristen Hartman, Allen Zhu, Bharathi Palanisamy, Gary Zenitsky, Huajun Jin, Vellareddy Anantharam, Arthi Kanthasamy, Chuan He, Anumantha G. Kanthasamy
Publikováno v:
iScience, Vol 27, Iss 9, Pp 110619- (2024)
Summary: As the most abundant glial cells in the central nervous system (CNS), astrocytes dynamically respond to neurotoxic stress, however, the key molecular regulators controlling the inflammatory status of these sentinels during neurotoxic stress
Externí odkaz:
https://doaj.org/article/644b233085804a1086375f92d94ebdfb
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 18 (2024)
Aberrant epigenetic modification has been implicated in the pathogenesis of Parkinson’s disease (PD), which is characterized by the irreversible loss of dopaminergic (DAergic) neurons. However, the mechanistic landscape of histone acetylation (ac)
Externí odkaz:
https://doaj.org/article/63c2899215434ce3927e01cb9468aee6
Autor:
Muhammet Ay, Adhithiya Charli, Monica Langley, Ahyoung Jang, Piyush Padhi, Huajun Jin, Vellareddy Anantharam, Balaraman Kalyanaraman, Arthi Kanthasamy, Anumantha G. Kanthasamy
Publikováno v:
Frontiers in Neuroscience, Vol 18 (2024)
Impaired mitochondrial function and biogenesis have strongly been implicated in the pathogenesis of Parkinson’s disease (PD). Thus, identifying the key signaling mechanisms regulating mitochondrial biogenesis is crucial to developing new treatment
Externí odkaz:
https://doaj.org/article/9538d014a4cc40849dd2e9312bfc0253
Autor:
Minhong Huang, Emir Malovic, Alyssa Ealy, Huajun Jin, Vellareddy Anantharam, Arthi Kanthasamy, Anumantha G. Kanthasamy
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Epigenetic reprogramming is the ability of innate immune cells to form memories of environmental stimuli (priming), allowing for heightened responses to secondary stressors. Herein, we explored microglial epigenetic marks using the known inflammagen
Externí odkaz:
https://doaj.org/article/7fbe1c50728644d1b09f961583a6277b
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
The real-time quaking-induced conversion (RT-QuIC) alpha-synuclein (aSyn) protein kinetic seeding assay has been very useful for detecting pathological aggregates in various synucleinopathies including Parkinson’s disease (PD). This biomarker assay
Externí odkaz:
https://doaj.org/article/cdd669b3f2364e1cb8f53ce82365c50c
Autor:
Benjamin W. Schlichtmann, Bharathi N. Palanisamy, Emir Malovic, Susheel K. Nethi, Piyush Padhi, Monica Hepker, Joseph Wurtz, Manohar John, Bhupal Ban, Vellareddy Anantharam, Anumantha G. Kanthasamy, Balaji Narasimhan, Surya K. Mallapragada
Publikováno v:
Biomolecules, Vol 13, Iss 8, p 1203 (2023)
To date, there is no cure for Parkinson’s disease (PD). There is a pressing need for anti-neurodegenerative therapeutics that can slow or halt PD progression by targeting underlying disease mechanisms. Specifically, preventing the build-up of alpha
Externí odkaz:
https://doaj.org/article/d7ded8fb5a7f411cb21c57b6b61c2a05
Autor:
Nyzil Massey, Denusha Shrestha, Sanjana Mahadev Bhat, Piyush Padhi, Chong Wang, Locke A. Karriker, Jodi D. Smith, Anumantha G. Kanthasamy, Chandrashekhar Charavaryamath
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 16 (2022)
Increased incidences of neuro-inflammatory diseases in the mid-western United States of America (USA) have been linked to exposure to agriculture contaminants. Organic dust (OD) is a major contaminant in the animal production industry and is central
Externí odkaz:
https://doaj.org/article/a2081a74fdf84bb4b933a22662c65ab0
Autor:
Piyush Padhi, Carter Worth, Gary Zenitsky, Huajun Jin, Kumar Sambamurti, Vellareddy Anantharam, Arthi Kanthasamy, Anumantha G. Kanthasamy
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
The human gut microbiota is a complex, dynamic, and highly diverse community of microorganisms. Beginning as early as in utero fetal development and continuing through birth to late-stage adulthood, the crosstalk between the gut microbiome and brain
Externí odkaz:
https://doaj.org/article/7ed39c9ba36d4a898939a236bb3f2a94
Autor:
Gregory D. Scott, Moriah R. Arnold, Thomas G. Beach, Christopher H. Gibbons, Anumantha G. Kanthasamy, Russell M. Lebovitz, Afina W. Lemstra, Leslie M. Shaw, Charlotte E. Teunissen, Henrik Zetterberg, Angela S. Taylor, Todd C. Graham, Bradley F. Boeve, Stephen N. Gomperts, Neill R. Graff-Radford, Charbel Moussa, Kathleen L. Poston, Liana S. Rosenthal, Marwan N. Sabbagh, Ryan R. Walsh, Miriam T. Weber, Melissa J. Armstrong, Jee A. Bang, Andrea C. Bozoki, Kimiko Domoto-Reilly, John E. Duda, Jori E. Fleisher, Douglas R. Galasko, James E. Galvin, Jennifer G. Goldman, Samantha K. Holden, Lawrence S. Honig, Daniel E. Huddleston, James B. Leverenz, Irene Litvan, Carol A. Manning, Karen S. Marder, Alexander Y. Pantelyat, Victoria S. Pelak, Douglas W. Scharre, Sharon J. Sha, Holly A. Shill, Zoltan Mari, Joseph F. Quinn, David J. Irwin
Publikováno v:
Frontiers in Neurology, Vol 12 (2022)
The Lewy Body Dementia Association (LBDA) held a virtual event, the LBDA Biofluid/Tissue Biomarker Symposium, on January 25, 2021, to present advances in biomarkers for Lewy body dementia (LBD), which includes dementia with Lewy bodies (DLBs) and Par
Externí odkaz:
https://doaj.org/article/e84d47ecb7c4440da3c49a05adb2450e