Zobrazeno 1 - 10 of 148 pro vyhledávání: '"A. G. Jochemsen"'
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Akademický článek
Breast cancer dormancy is associated with a 4NG1 state and not senescence
Autor: Chloé Prunier, Ania Alay, Michiel van Dijk, Kelly L. Ammerlaan, Sharon van Gelderen, Dieuwke L. Marvin, Amina Teunisse, Roderick C. Slieker, Karoly Szuhai, A. G. Jochemsen, Xavier Solé, Peter ten Dijke, Laila Ritsma
Publikováno v: npj Breast Cancer, Vol 7, Iss 1, Pp 1-12 (2021)
Abstract Reactivation of dormant cancer cells can lead to cancer relapse, metastasis, and patient death. Dormancy is a nonproliferative state and is linked to late relapse and death. No targeted therapy is currently available to eliminate dormant cel
Externí odkaz: https://doaj.org/article/1a7695e25ac44d42a318fcdc5ab8c2ee
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2
Akademický článek
Patient-derived zebrafish xenografts of uveal melanoma reveal ferroptosis as a drug target
Autor: Arwin Groenewoud, Jie Yin, Maria Chiara Gelmi, Samar Alsafadi, Fariba Nemati, Didier Decaudin, Sergio Roman-Roman, Helen Kalirai, Sarah E. Coupland, Aart G. Jochemsen, Martine J. Jager, Felix B. Engel, B. E. Snaar-Jagalska
Publikováno v: Cell Death Discovery, Vol 9, Iss 1, Pp 1-11 (2023)
Abstract Uveal melanoma (UM) has a high risk to progress to metastatic disease with a median survival of 3.9 months after metastases detection, as metastatic UM responds poorly to conventional and targeted chemotherapy and is largely refractory to im
Externí odkaz: https://doaj.org/article/35f875d9b6ee4910a5099e5b1b9ef6e8
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3
Akademický článek
Zebrafish Patient-Derived Xenograft Model as a Preclinical Platform for Uveal Melanoma Drug Discovery
Autor: Jie Yin, Gangyin Zhao, Helen Kalirai, Sarah E. Coupland, Aart G. Jochemsen, Gabriel Forn-Cuní, Annemijn P. A. Wierenga, Martine J. Jager, B. Ewa Snaar-Jagalska, Arwin Groenewoud
Publikováno v: Pharmaceuticals, Vol 16, Iss 4, p 598 (2023)
Uveal melanoma (UM) is a rare malignant cancer of the eye, with up to 50% of patients dying from metastasis, for which no effective treatment is available. Due to the rarity of the disease, there is a great need to harness the limited material availa
Externí odkaz: https://doaj.org/article/926cbf25627a4e6385fb3c70e89d75a4
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4
FAK Inhibitor-Based Combinations with MEK or PKC Inhibitors Trigger Synergistic Antitumor Effects in Uveal Melanoma
Autor: Malcy Tarin, Fariba Némati, Didier Decaudin, Christine Canbezdi, Benjamin Marande, Lisseth Silva, Héloïse Derrien, Aart G. Jochemsen, Sophie Gardrat, Sophie Piperno-Neumann, Manuel Rodrigues, Pascale Mariani, Nathalie Cassoux, Marc-Henri Stern, Sergio Roman-Roman, Samar Alsafadi
Publikováno v: Cancers; Volume 15; Issue 8; Pages: 2280
Uveal Melanoma (UM) is a rare and malignant intraocular tumor with dismal prognosis. Even if radiation or surgery permit an efficient control of the primary tumor, up to 50% of patients subsequently develop metastases, mainly in the liver. The treatm
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e8b1dd540b01db9fd80f518fcc4bc1d
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10
MDMX regulates transcriptional activity of p53 and FOXO proteins to stimulate proliferation of melanoma cells
Autor: Renier C. Heijkants, Amina F. A. S. Teunisse, Danielle de Jong, Kseniya Glinkina, Hailiang Mei, Szymon M. Kielbasa, Karoly Szuhai, Aart G. Jochemsen
Publikováno v: Cancers, 14(18). MDPI
Cancers; Volume 14; Issue 18; Pages: 4482
The tumor suppressor protein p53 has an important role in cell-fate determination. In cancer cells, the activity of p53 is frequently repressed by high levels of MDMX and/or MDM2. MDM2 is a ubiquitin ligase whose activity results in ubiquitin- and pr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59287390865d2e1d3056c99ea70e3967
https://hdl.handle.net/1887/3562152
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