Výsledky vyhledávání - "A. G. Jochemsen"

Akademický článek

Patient-derived zebrafish xenografts of uveal melanoma reveal ferroptosis as a drug target

Autor: Arwin Groenewoud, Jie Yin, Maria Chiara Gelmi, Samar Alsafadi, Fariba Nemati, Didier Decaudin, Sergio Roman-Roman, Helen Kalirai, Sarah E. Coupland, Aart G. Jochemsen, Martine J. Jager, Felix B. Engel, B. E. Snaar-Jagalska

Publikováno v: Cell Death Discovery, Vol 9, Iss 1, Pp 1-11 (2023)

Abstract Uveal melanoma (UM) has a high risk to progress to metastatic disease with a median survival of 3.9 months after metastases detection, as metastatic UM responds poorly to conventional and targeted chemotherapy and is largely refractory to im

Externí odkaz: https://doaj.org/article/35f875d9b6ee4910a5099e5b1b9ef6e8

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Akademický článek

Breast cancer dormancy is associated with a 4NG1 state and not senescence

Autor: Chloé Prunier, Ania Alay, Michiel van Dijk, Kelly L. Ammerlaan, Sharon van Gelderen, Dieuwke L. Marvin, Amina Teunisse, Roderick C. Slieker, Karoly Szuhai, A. G. Jochemsen, Xavier Solé, Peter ten Dijke, Laila Ritsma

Publikováno v: npj Breast Cancer, Vol 7, Iss 1, Pp 1-12 (2021)

Abstract Reactivation of dormant cancer cells can lead to cancer relapse, metastasis, and patient death. Dormancy is a nonproliferative state and is linked to late relapse and death. No targeted therapy is currently available to eliminate dormant cel

Externí odkaz: https://doaj.org/article/1a7695e25ac44d42a318fcdc5ab8c2ee

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Akademický článek

Zebrafish Patient-Derived Xenograft Model as a Preclinical Platform for Uveal Melanoma Drug Discovery

Autor: Jie Yin, Gangyin Zhao, Helen Kalirai, Sarah E. Coupland, Aart G. Jochemsen, Gabriel Forn-Cuní, Annemijn P. A. Wierenga, Martine J. Jager, B. Ewa Snaar-Jagalska, Arwin Groenewoud

Publikováno v: Pharmaceuticals, Vol 16, Iss 4, p 598 (2023)

Uveal melanoma (UM) is a rare malignant cancer of the eye, with up to 50% of patients dying from metastasis, for which no effective treatment is available. Due to the rarity of the disease, there is a great need to harness the limited material availa

Externí odkaz: https://doaj.org/article/926cbf25627a4e6385fb3c70e89d75a4

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Akademický článek

Lack of myeloid cell infiltration as an acquired resistance strategy to immunotherapy

Autor: Sjoerd H van der Burg, Suzanne van Duikeren, Ramon Arens, Thorbald van Hall, Ziena Abdulrahman, Elham Beyranvand Nejad, Jan Willem Kleinovink, Noel F C C de Miranda, Camilla Labrie, Marit J van Elsas, Eva Rademaker, Tetje C van der Sluis, Amina F A.S Teunisse, Aart G Jochemsen, Jan Oosting

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)

Background Immunotherapy of cancer is successful but tumor regression often is incomplete and followed by escape. Understanding the mechanisms underlying this acquired resistance will aid the development of more effective treatments.Methods We exploi

Externí odkaz: https://doaj.org/article/520202f95b084831848aa302833ae70b

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Akademický článek

Fluorescent CXCR4 targeting peptide as alternative for antibody staining in Ewing sarcoma

Autor: Laurens G. L. Sand, Tessa Buckle, Fijs W. B. van Leeuwen, Willem E. Corver, Alwine B. Kruisselbrink, Aart G. Jochemsen, Pancras C. W. Hogendoorn, Károly Szuhai

Publikováno v: BMC Cancer, Vol 17, Iss 1, Pp 1-9 (2017)

Abstract Background Ewing sarcoma is an aggressive, highly metastatic primary bone and soft tissue tumor most frequently occurring in the bone of young adolescents. Patients, especially those diagnosed with a metastatic disease, have a poor overall s

Externí odkaz: https://doaj.org/article/146633a273e64b18832ca1956fb90d90

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