Zobrazeno 1 - 10
of 215
pro vyhledávání: '"A. G. Jenner"'
Autor:
Jonathan W. Lo, Jan-Hendrik Schroeder, Luke B. Roberts, Rami Mohamed, Domenico Cozzetto, Gordon Beattie, Omer S. Omer, Ellen M. Ross, Frank Heuts, Geraldine M. Jowett, Emily Read, Matthew Madgwick, Joana F. Neves, Tamas Korcsmaros, Richard G. Jenner, Lucy S. K. Walker, Nick Powell, Graham M. Lord
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract The maintenance of intestinal homeostasis is a fundamental process critical for organismal integrity. Sitting at the interface of the gut microbiome and mucosal immunity, adaptive and innate lymphoid populations regulate the balance between
Externí odkaz:
https://doaj.org/article/9c1706884f1e46cd8fa10a092e27a500
Publikováno v:
Cell Reports, Vol 43, Iss 3, Pp 113856- (2024)
Summary: Polycomb repressive complex 2 (PRC2) modifies chromatin to maintain repression of genes specific for other cell lineages. In vitro, RNA inhibits PRC2 activity, but the effect of RNA on PRC2 in cells is less clear, with studies concluding tha
Externí odkaz:
https://doaj.org/article/132b5495278744eab73b7590c4ca1319
Autor:
Hayley Porter, Yang Li, Maria Victoria Neguembor, Manuel Beltran, Wazeer Varsally, Laura Martin, Manuel Tavares Cornejo, Dubravka Pezić, Amandeep Bhamra, Silvia Surinova, Richard G Jenner, Maria Pia Cosma, Suzana Hadjur
Publikováno v:
eLife, Vol 12 (2023)
Most studies of cohesin function consider the Stromalin Antigen (STAG/SA) proteins as core complex members given their ubiquitous interaction with the cohesin ring. Here, we provide functional data to support the notion that the SA subunit is not a m
Externí odkaz:
https://doaj.org/article/c75b957f25434498af13a92ce3fcf355
Autor:
Jan-Hendrik Schroeder, Gordon Beattie, Jonathan W. Lo, Tomasz Zabinski, Nick Powell, Joana F. Neves, Richard G. Jenner, Graham M. Lord
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Huge progress has been made in understanding the biology of innate lymphoid cells (ILC) by adopting several well-known concepts in T cell biology. As such, flow cytometry gating strategies and markers, such as CD90, have been applied to indentify ILC
Externí odkaz:
https://doaj.org/article/51f45fc4faa84fa3900e89aef90a55fc
Autor:
Arnulf Hertweck, Catherine M. Evans, Malihe Eskandarpour, Jonathan C.H. Lau, Kristine Oleinika, Ian Jackson, Audrey Kelly, John Ambrose, Peter Adamson, David J. Cousins, Paul Lavender, Virginia L. Calder, Graham M. Lord, Richard G. Jenner
Publikováno v:
Cell Reports, Vol 15, Iss 12, Pp 2756-2770 (2016)
The transcription factor T-bet directs Th1 cell differentiation, but the molecular mechanisms that underlie this lineage-specific gene regulation are not completely understood. Here, we show that T-bet acts through enhancers to allow the recruitment
Externí odkaz:
https://doaj.org/article/62e0042e1c2743aca84f38295c4cab13
Autor:
Adrienne M. Flanagan, Udo Oppermann, Richard G. Jenner, Nischalan Pillay, Paul E. Brennan, Catrine Johansson, Tamas Szommer, Edward S. Hookway, Patrick Lombard, Anthony Tumber, Martin Philpott, Lorena Ligammari, Graham Wells, Garima Khandelwal, Adam P. Cribbs, Lucia Cottone
Cottone_Dataset_S3_Chordoma_UCH1_K27Me3_GEA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6557446fa21738c480aef8c390e948bd
https://doi.org/10.1158/0008-5472.22426558.v1
https://doi.org/10.1158/0008-5472.22426558.v1
Autor:
Adrienne M. Flanagan, Udo Oppermann, Richard G. Jenner, Nischalan Pillay, Paul E. Brennan, Catrine Johansson, Tamas Szommer, Edward S. Hookway, Patrick Lombard, Anthony Tumber, Martin Philpott, Lorena Ligammari, Graham Wells, Garima Khandelwal, Adam P. Cribbs, Lucia Cottone
Supplementary Information
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c485bbf1b953bd1304c5c3572926d52
https://doi.org/10.1158/0008-5472.22426555.v1
https://doi.org/10.1158/0008-5472.22426555.v1
Autor:
Adrienne M. Flanagan, Udo Oppermann, Richard G. Jenner, Nischalan Pillay, Paul E. Brennan, Catrine Johansson, Tamas Szommer, Edward S. Hookway, Patrick Lombard, Anthony Tumber, Martin Philpott, Lorena Ligammari, Graham Wells, Garima Khandelwal, Adam P. Cribbs, Lucia Cottone
Expression of the transcription factor brachyury (TBXT) is normally restricted to the embryo, and its silencing is epigenetically regulated. TBXT promotes mesenchymal transition in a subset of common carcinomas, and in chordoma, a rare cancer showing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8212a639932c9ee33a88afa370634f22
https://doi.org/10.1158/0008-5472.c.6512377
https://doi.org/10.1158/0008-5472.c.6512377
Autor:
Georgios Vlachogiannis, Chad E. Niederhuth, Salih Tuna, Athanasia Stathopoulou, Keijo Viiri, Dirk G. de Rooij, Richard G. Jenner, Robert J. Schmitz, Steen K.T. Ooi
Publikováno v:
Cell Reports, Vol 10, Iss 6, Pp 944-956 (2015)
A critical aspect of mammalian gametogenesis is the reprogramming of genomic DNA methylation. The catalytically inactive adaptor Dnmt3L is essential to ensuring this occurs correctly, but the mechanism by which it functions is unclear. Using gene tar
Externí odkaz:
https://doaj.org/article/098faeee7f7a4b87bf7610b98bb7d1a3
Autor:
Katrina Soderquest, Arnulf Hertweck, Claudia Giambartolomei, Stephen Henderson, Rami Mohamed, Rimma Goldberg, Esperanza Perucha, Lude Franke, Javier Herrero, Vincent Plagnol, Richard G Jenner, Graham M Lord
Publikováno v:
PLoS Genetics, Vol 13, Iss 2, p e1006587 (2017)
The polarization of CD4+ T cells into distinct T helper cell lineages is essential for protective immunity against infection, but aberrant T cell polarization can cause autoimmunity. The transcription factor T-bet (TBX21) specifies the Th1 lineage an
Externí odkaz:
https://doaj.org/article/1b047c1f9aaf46738e2b7b4684f706e9